Colorectal cancer(CRC)is one of the most common malignancies worldwide,although anti-angiogenic targeted agents such as bevacizum-ab have shown significant efficacy in the treatment of metastatic CRC,however,the emergence of drug resistance is still a key obstacle affecting the suc-cess rate of treatment and survival of patients.This article reviews the progress of anti-angiogenesis targeted drugs in the treatment of CRC,the mecha-nism of drug resistance and how to solve the prob-lem of drug resistance.

Colorectal cancer(CRC)is one of the most common malignancies worldwide,although anti-angiogenic targeted agents such as bevacizum-ab have shown significant efficacy in the treatment of metastatic CRC,however,the emergence of drug resistance is still a key obstacle affecting the suc-cess rate of treatment and survival of patients.This article reviews the progress of anti-angiogenesis targeted drugs in the treatment of CRC,the mecha-nism of drug resistance and how to solve the prob-lem of drug resistance.

Postoperative abdominal adhesions, commonly known as postoperative intestinal adhesions, refers to abnormal adhesions between abdominal organs or between abdominal organs and the wall peritoneum caused by surgical injuries, which is the most common complication of abdominal surgery. Patients usually experience abdominal pain, abdominal distension, constipation, and in severe symptoms such as intestinal obstruction, intestinal necrosis, and female infertility, which seriously affect their quality of life and make it difficult to undergo another surgery. At present, postoperative abdominal adhesions are mainly prevented, and there is still no reliable diagnosis and treatment strategy for patients who experience adhesion-related symptoms after surgery. The current diagnosis still relies on surgical exploration as the gold standard, and can also be diagnosed based on clinical manifestations, combined with ultrasound, cine-MRI, and some laboratory tests. Gas abdominal CT three-dimensional simulation imaging of the peritoneal cavity is a promising diagnostic method. Although surgery is widely recognized as an effective treatment method, clinicians only choose surgical intervention when dealing with severe acute adhesive intestinal obstruction patients. Therefore, the current treatment mainly includes non-surgical treatment including traditional chinese medicine. This article reviews the progress in the diagnosis and treatment of postoperative abdominal adhesions in order to provide new ideas for clinical diagnosis and treatment.

Objective To explore the effect of Jianpi Liqi(JPLQ)on the survival time of postoperative patients with colorectal cancer(CRC),and screen the independent factors affecting the prognosis of these patients.Methods A retrospective study was conduc-ted on 254 postoperative CRC patients who were admitted to the Department of General surgery,Longhua Hospital Affiliated to Shanghai University of TCM from July 2015 to December 2022.According to the use of ttraditional Chinese medicine(TCM)or JPLQ after the op-eration,they were divided into three groups:JPLQ group(n=51),non-JPLQ group(n=126)and western medicine group(n=77).The overall survival time was taken as the main observation index,then the survival curve was drawn by Kaplan-Meier,and the differ-ence of survival rate was compared by Log-rank test.The COX proportional hazard model was introduced to screen the statistically signifi-cant factors,univariate COX regression analysis preliminarily screened out the factors affecting the postoperative prognosis of CRC pa-tients,then stepwise regression was used for multivariate analysis to screen out the independent related factors that ultimately affect the prognosis of postoperative CRC patients.Results There was no significant difference among the survival curves of JPLQ group,non-JPLQ group and western medicine group.The results of univariate COX regression analysis showed that pathological stage Ⅲ-Ⅳ,number of positive lymph nodes,nerve/vascular invasion,mode of operation and biliary diseases were significant factors that may affect postopera-tive prognosis of CRC patients(P＜0.05).The results of multivariate COX regression analysis showed that more positive lymph nodes were the independent risk factor affecting the prognosis of CRC,while receiving laparoscopic surgery and having biliary diseases were inde-pendent protective factors affecting the prognosis of CRC(P＜0.05).Conclusion Compared with single western medical treatment,combination with western medicine and TCM especially represented as JPLQ has a tendency to prolong the survival time of CRC patients.More positive lymph nodes are the independent risk factors affecting the prognosis of CRC,while receiving laparoscopic surgery and having biliary diseases are independent protective factors.

Objective To explore the effect of Jianpi Liqi(JPLQ)on the survival time of postoperative patients with colorectal cancer(CRC),and screen the independent factors affecting the prognosis of these patients.Methods A retrospective study was conduc-ted on 254 postoperative CRC patients who were admitted to the Department of General surgery,Longhua Hospital Affiliated to Shanghai University of TCM from July 2015 to December 2022.According to the use of ttraditional Chinese medicine(TCM)or JPLQ after the op-eration,they were divided into three groups:JPLQ group(n=51),non-JPLQ group(n=126)and western medicine group(n=77).The overall survival time was taken as the main observation index,then the survival curve was drawn by Kaplan-Meier,and the differ-ence of survival rate was compared by Log-rank test.The COX proportional hazard model was introduced to screen the statistically signifi-cant factors,univariate COX regression analysis preliminarily screened out the factors affecting the postoperative prognosis of CRC pa-tients,then stepwise regression was used for multivariate analysis to screen out the independent related factors that ultimately affect the prognosis of postoperative CRC patients.Results There was no significant difference among the survival curves of JPLQ group,non-JPLQ group and western medicine group.The results of univariate COX regression analysis showed that pathological stage Ⅲ-Ⅳ,number of positive lymph nodes,nerve/vascular invasion,mode of operation and biliary diseases were significant factors that may affect postopera-tive prognosis of CRC patients(P＜0.05).The results of multivariate COX regression analysis showed that more positive lymph nodes were the independent risk factor affecting the prognosis of CRC,while receiving laparoscopic surgery and having biliary diseases were inde-pendent protective factors affecting the prognosis of CRC(P＜0.05).Conclusion Compared with single western medical treatment,combination with western medicine and TCM especially represented as JPLQ has a tendency to prolong the survival time of CRC patients.More positive lymph nodes are the independent risk factors affecting the prognosis of CRC,while receiving laparoscopic surgery and having biliary diseases are independent protective factors.