The chemical constituents of Justicia procumbens are mainly lignans,flavonoids,alkaloids,etc.It is commonly used in clinical practice as an adjunctive treatment for malaria,fevers,coughs of pulmonary fever,poisonous snake bites and other diseases.Modern pharmacological studies have shown that Justicia procumbens has anti-platelet aggregation,analgesic,anti-tumor and anti-inflammatory effects.In this review,the herbal evidence of Justicia procumbens was summarised in more detail,and the chemical composition,the pharmacological effects and clinical applications of Justicia procumbens were summarised in combination with domestic and international studies,and the quality marker(Q-Marker)of Justicia procumbens was predicted and analyzed on the basis of the Five Principles,network pharmacology,and traditional medicinal properties.The preliminary predictions of 6'-hydroxy justicidin A,6'-hydroxy justicidin B,6'-hydroxy justicidin C,justicidin B,Chinensinaphthol methyl ether,and kaempferol were used as the Q-Markers of Justicia procumbens with a view to provide a reference for the better development and utilisation of Justicia resources.

Objective To systematically evaluate the relationship between the dietary inflammatory in-dex(DII)and the onset risk of gestational diabetes mellitus(GDM).Methods The databases such as PubMed,Web of Science,Embase,Cochrane Library,CNKI and Wanfang Data were retrieved.The retrieval time was from the database establishment to September 10,2023.Two researchers separately screened the lit-eratures,extracted the data and conducted the bias risk assessment.The meta analysis was conducted by the RevMan 5.4 software.Results A total of 8 observational studies were included,involving 96 904 pregnant women.The results of meta-analysis showed that in the classified DII,compared with the DII anti-inflammato-ry tendency group,the risk of GDM onset in the DII pro-inflammatory tendency group was increased(OR=1.27,95％CI:1.07-1.50,P=0.006).In the continuous DII,for every unit increase in DII,the risk of GDM was increased by 29％(OR=1.29,95％CI:1.13-1.48,P＜0.001).In the subgroup analysis,the most of the stratified analysis results were consistent with the main analysis results.Conclusion The current evidence suggests that the high DII scores will increase the risk of GDM onset,but the aforementioned conclusion re-quires the validation through more high quality,large samples and multicenter studies.

Objective To explore the activition and polarization of microglia in the epileptic rats induced by lithium chloride-pilocarpine. Methods One hundred male SD rats were randomly divided into five groups: control group and different time points model groups including 1d,3d,7d and 14d. Epilepsy models were established by lithium chloride-pilocarpine intraperitoneal injection. The control group was given the same dosage of normal saline. The morphology change was detected by immunofluorescence,and the expressions of iNOS and Arg-1 were determined by IHC at respective time points. Results Compared the model groups with control group,microglia was activated,synapsis was shorten,volume got bigger,most of them seemed as amoebocyte,the expression of iNOS increased and Arg-1 decreased,especially at 3d.ConclusionThe results from this study indicated that microglia was activated and polarized in epileptic rats induced by pilocarpine.

Objective To explo the antioxidant effect and molecular mechanism of gastrodin (Gas) in epilepsy (EP) rats induced by LiCl-pilocarpine (PILO) . Methods Eighty male SD rats were randomly divided into 5 groups: sham group, EP group, therapy groups (pretreated with 60 mg/kg, 90 mg/kg, 120 mg/kg of gastrodin respectively) . The EP model was esteblished by peritoneal injection of LiCl-PILO. Therapy groups were pretreated with various concerntration of Gas. The control group was given the same dosage of normal saline. The alteration of behavior was observed, the concentration of catalase (CAT), glutathion (GSH), superoxide dismutase (SOD), glutathion reductase (GR), total antioxidtion (T-AOC) and malondialdehyde (MDA) in rats brain cortex were detected by chemical colorimetric method, phosphorylation of p38 was determined by western blot. Results There was no EP seizure in sham group,and the EP seizure degree in therapy groups (gas pretreated groups) was significantly decreased,and had statistically significant difference with EP group (P<0.05) . The EP model rats exhibited a significant decrease in the concentration of endogenous antioxidants (CAT, GSH, SOD, GR and T-AOC), while an increase of the concentration of MDA and phosphorylation p38 protein as compared to sham group (P<0.05) . After treatment of the Gas,treatment group rats attenuated the seizure degree,exhibited a significant increase of the concentration of endogenous antioxidants (P<0.05),while a decrease in concentration of MDA and phosphorylation of p38 as compared to model group (P<0.05) . Conclusion Gas may have a neuroprotective role in central nervous system of epileptic rats modle by down-regulateing the seizure degree and the activity of p38 kinase and up-regulateing the content of endogenous antioxidants.

Objective To summarize the nursing experience of 1 case of very low birth weight infant decannulation difficult in PICC. Methods The nursing key points included: full assessment analysis decannulation difficult reason, consult the PICC catheter outpatient health nurses, give magnesium sulfate hydropathic compress, mucopolysaccharide polysulfate cream local besmear outside, sanyrene outside, at the same time give low-molecular-weight heparin calcium injection subcutaneous injection such as anticoagulant active treatment and nursing. Results After 7 days ,the infant left axillary mass dispel, PICC pull out smoothly. Conclusions Decannulation difficult of very low birth weight infant requires full evaluation, multidisciplinary cooperation and specialist consultation, can give targeted personalized nursing safety smooth tube drawing, is worthy of reference for clinic.

ObjectiveTo observe the clinical efficacy ofelectroacupunctureplustopical laser treatmentin treating hyperplasia of mammary glands.MethodFifty-eight patients with hyperplasia of mammary glands were randomized into a treatment group of 30 cases and a control group of 28 cases. The treatment group was intervened byelectroacupunctureplustopical laser treatment, while the controlgroup was by oral administration of Ru Zeng Ning tablets. The intervention began from 15 d prior to the menstrual period. After 3 successive treatment courses, the clinical efficacies were compared, and the efficacies in treating three different patterns of mammary glands hyperplasia were also compared, i.e. qi-stagnation due to liver depression, accumulation of phlegm and stagnation, and imbalance of the Thoroughfare and Conception Vessels.ResultAccording to the comprehensive efficacy evaluation, the total effective rate was 86.7% in the treatment group versus 57.1% in the control group, and the difference was statistically significant (P<0.05). The efficacy of the treatment group in treating the pattern of qi-stagnation due to liver depression was significantly higher than that in of the control group (P<0.05); there were no significant differences in comparing the efficacies in treating the types of accumulation of phlegm and stagnation and imbalance of the Thoroughfare and Conception Vessels between the two groups (P>0.05).ConclusionElectroacupunctureplustopical laser treatmentis effective in treating hyperplasia of mammary glands, especially for the type of qi-stagnation due to liver depression.

Echinacea is a most famous "immune herb" in western countries, and continues to be the best selling herb for many years. For the last five years, our research group has cooperated with Institute of Medicinal Plants in Huairou District of Beijing, carrying out studies on Echinacea purpurea, which involved botany, cultivation, pharmacognosy, phytochemistry, quality control, pharmacology and toxicology of the species. Two other species introduced from Canada, Echinacea angustifolia and Echinacea pallida, were also included in the taxonomic, cultivated and pharmacognostic studies. The results acquired have opened up the path to introduce Echinacea species into Traditional Chinese Medicine, thus established the possibility of developing more promising drugs from them.