Objective To study the therapeutic effect of hypothermic perfusion fluid in manual small incision cataract surgery(MSICS).Methods A total of 60 elderly patients with hard cataracts undergoing MSICS at Nanjing Central Hospital(Nanjing Municipal Government Hospital)from January to September 2024 were selected as subjects,they were divided into hypothermic group(n=29)and normal temperature group(n=31)by using a random number table method.Hypothermic group received 4℃intraocular perfusion fluid during surgery,while normal temperature group received 22 ℃ intraocular perfusion fluid.The study compared differences in best corrected visual acuity(BCVA),intraocular pressure,endothelial cell density(ECD),and central macular thickness(CMT)between two groups before and after surgery.Postoperative ocular complications within three months were also recorded for both groups.Results Hypothermic group showed significantly higher ECD levels at 1 day postoperative,1 week postoperative,and 3-month postoperative compared to normal temperature group,with statistically significant differences(P＜0.05).Hypothermic group exhibited lower rates of corneal edema on day 1 postoperative,reduced macular edema incidence at 3-month follow-up,and overall lower incidence of complications than normal temperature group,the difference was statistically significant(P＜0.05).Conclusion The use of hypothermic perfusion fluid in MSICS treatment of senile hard corneal cataract can protect corneal endothelial cells,reduce early postoperative corneal edema,and significantly reduce the incidence of common postoperative complications.

Objective To study the therapeutic effect of hypothermic perfusion fluid in manual small incision cataract surgery(MSICS).Methods A total of 60 elderly patients with hard cataracts undergoing MSICS at Nanjing Central Hospital(Nanjing Municipal Government Hospital)from January to September 2024 were selected as subjects,they were divided into hypothermic group(n=29)and normal temperature group(n=31)by using a random number table method.Hypothermic group received 4℃intraocular perfusion fluid during surgery,while normal temperature group received 22 ℃ intraocular perfusion fluid.The study compared differences in best corrected visual acuity(BCVA),intraocular pressure,endothelial cell density(ECD),and central macular thickness(CMT)between two groups before and after surgery.Postoperative ocular complications within three months were also recorded for both groups.Results Hypothermic group showed significantly higher ECD levels at 1 day postoperative,1 week postoperative,and 3-month postoperative compared to normal temperature group,with statistically significant differences(P＜0.05).Hypothermic group exhibited lower rates of corneal edema on day 1 postoperative,reduced macular edema incidence at 3-month follow-up,and overall lower incidence of complications than normal temperature group,the difference was statistically significant(P＜0.05).Conclusion The use of hypothermic perfusion fluid in MSICS treatment of senile hard corneal cataract can protect corneal endothelial cells,reduce early postoperative corneal edema,and significantly reduce the incidence of common postoperative complications.