Objective:To analyze the abnormal features of brain structure and functional connection (FC) in adolescent female patients with borderline personality disorder (BPD) and to explore the relationship between brain structure and clinical severity.Method:Eighteen female patients with BPD and 18 healthy controls matched with sex, age and education level aged 12—17 were examined by resting functional magnetic resonance imaging (fMRI). The differences of gray matter volume (GMV) and functional connection between the two groups were compared by voxel-based morphometric measurement and functional connection method, and t-test was used to compare the differences between the two groups. Spearman correlation analysis was used to analyze the correlation between abnormal brain regions, brain regions with different functional connections and Borderline Symptom List (BSL-23) scores. Result:The GMV of the left inferior temporal gyrus ( t=4.23), the right inferior temporal gyrus ( t=4.85), and the left middle orbital frontal gyrus ( t=4.16) were significantly larger in the BPD group than those in the healthy controls (GRF corrected voxel P<0.005, cluster P<0.05 two-tails). FC decreased in left inferior temporal gyrus and right middle temporal gyrus ( t=-6.20), increased in the left inferior temporal gyrus and the right fusiform gyrus ( t=5.75), the left inferior temporal gyrus and the left inferior parietal marginal angular gyrus ( t=4.38;GRF corrected voxel P<0.005, cluster P<0.05, two-tailed). In the BPD group, the increase in orbital frontal gray matter volume was negatively correlated with the emotional items BSL9 (tension; r=-0.523, P=0.023), BSL14 (rapid emotional changes; r=-0.549, P=0.018), BSL15 (tolerated pain; r=-0.589, P=0.010), BSL17 (vulnerable; r=-0.554, P=0.017), BSL5 (self-injury; r=-0.616, P=0.006) and BSL18 (suicide attraction; r=-0.661, P=0.003) in the BSL-23. Conclusion:There are differences in the GMV of the inferior temporal and the left middle orbital frontal lobe in adolescent female patients with BPD. The FC abnormalities of the left inferior temporal and right middle temporal gyrus, the left inferior temporal gyrus and the right fusiform gyrus, the left inferior temporal gyrus and the left inferior parietal marginal angular gyrus, especially the changes of GMV in the orbital frontal brain structure might participate in the pathological mechanism of emotion regulation injury in patients with BPD.

Objective:To analyze the abnormal features of brain structure and functional connection (FC) in adolescent female patients with borderline personality disorder (BPD) and to explore the relationship between brain structure and clinical severity.Method:Eighteen female patients with BPD and 18 healthy controls matched with sex, age and education level aged 12—17 were examined by resting functional magnetic resonance imaging (fMRI). The differences of gray matter volume (GMV) and functional connection between the two groups were compared by voxel-based morphometric measurement and functional connection method, and t-test was used to compare the differences between the two groups. Spearman correlation analysis was used to analyze the correlation between abnormal brain regions, brain regions with different functional connections and Borderline Symptom List (BSL-23) scores. Result:The GMV of the left inferior temporal gyrus ( t=4.23), the right inferior temporal gyrus ( t=4.85), and the left middle orbital frontal gyrus ( t=4.16) were significantly larger in the BPD group than those in the healthy controls (GRF corrected voxel P<0.005, cluster P<0.05 two-tails). FC decreased in left inferior temporal gyrus and right middle temporal gyrus ( t=-6.20), increased in the left inferior temporal gyrus and the right fusiform gyrus ( t=5.75), the left inferior temporal gyrus and the left inferior parietal marginal angular gyrus ( t=4.38;GRF corrected voxel P<0.005, cluster P<0.05, two-tailed). In the BPD group, the increase in orbital frontal gray matter volume was negatively correlated with the emotional items BSL9 (tension; r=-0.523, P=0.023), BSL14 (rapid emotional changes; r=-0.549, P=0.018), BSL15 (tolerated pain; r=-0.589, P=0.010), BSL17 (vulnerable; r=-0.554, P=0.017), BSL5 (self-injury; r=-0.616, P=0.006) and BSL18 (suicide attraction; r=-0.661, P=0.003) in the BSL-23. Conclusion:There are differences in the GMV of the inferior temporal and the left middle orbital frontal lobe in adolescent female patients with BPD. The FC abnormalities of the left inferior temporal and right middle temporal gyrus, the left inferior temporal gyrus and the right fusiform gyrus, the left inferior temporal gyrus and the left inferior parietal marginal angular gyrus, especially the changes of GMV in the orbital frontal brain structure might participate in the pathological mechanism of emotion regulation injury in patients with BPD.

Non-suicidal self-injury (NSSI) is becoming increasingly common. NSSI is typically associated with emotional and psychiatric distress and mainly seriously affects mental health in adolescents. Trait impulsivity, reward circuitry, and the endogenous opioid system are all playing an essential role in the neurobiological mechanism. This review conceptualizes the neurobiology of NSSI based upon the new research evidence.

Non-suicidal self-injury (NSSI) is becoming increasingly common. NSSI is typically associated with emotional and psychiatric distress and mainly seriously affects mental health in adolescents. Trait impulsivity, reward circuitry, and the endogenous opioid system are all playing an essential role in the neurobiological mechanism. This review conceptualizes the neurobiology of NSSI based upon the new research evidence.

Since December 2019, novel coronavirus pneumonia (NCP) has been reported in Wuhan, Hubei Province, and spreads rapidly to all through Hubei Province and even to the whole country. The virus is 2019 novel coronavirus (2019-nCoV), never been seen previously in human, but all the population is generally susceptible. The virus spreads through many ways and is highly infectious, which brings great difficulties to the prevention and control of NCP. Based on the needs of orthopedic trauma patients for emergency surgery and review of the latest NCP diagnosis and treatment strategy and the latest principles and principles of evidence-based medicine in traumatic orthopedics, the authors put forward this expert consensus to systematically standardize the clinical pathway and protective measures of emergency surgery for orthopedic trauma patients during prevention and control of NCP and provide reference for the emergency surgical treatment of orthopedic trauma patients in hospitals at all levels.