BACKGROUND

Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome caused by PRKAR1A gene mutation and  characterized by lentigines, myxomatous tumors and various endocrine neoplasms.

CASE PRESENTATION

This is a case of a 52-year-old male patient who underwent echocardiogram for intermittent palpitations and near-syncopal attack, which revealed a left atrial myxoma. The patient also exhibited multiple lentigines and had a history of histologicallyconfirmed papillary thyroid carcinoma. Surgical excision and subsequent histopathologic examination confirmed cardiac myxoma, fulfilling three major Stratakis criteria for CNC.

DISCUSSION

This case highlights the importance of a thorough history and physical examination with a strong understanding of the syndrome’s features being key to recognizing the disease. Increasing awareness and reinforcing knowledge of CNC are crucial for preventing misdiagnosis and ensuring effective management of this rare condition. To our knowledge, this is the first published case report of CNC in the Philippines, emphasizing the need for heightened regional awareness.

CONCLUSION

CNC may present with subtle or nonspecific symptoms and atypical tumor locations. Early recognition through a high index of suspicion, targeted imaging and a multidisciplinary approach is critical to optimize outcomes and guide family screening in this rare syndrome.

Human ; Male ; Middle Aged: 45-64 Yrs Old ; Multiple Endocrine Neoplasia ; Carney Complex ; Myxoma ; Syndrome ; Neoplasms ; Mutation ; Lentigo ; Genes

OBJECTIVE: This controlled study was done to determine the protective effects of ischemic preconditioning (IP) on the liver of cats undergoing major liver resection.
SPECIFIC OBJECTIVE: To determine the effect of IP on alanine transaminase (ALT or SGPT) in cat*that will undergo major liver resection.
DESIGN: This study is a randomized controlled trial.
SETTING: LIST Health Sciences Research Laboratory.
PATIENTS/ PARTICIPANTS: This is an experimental study on the effects of ischemic preconditioning under hepatic inflow occlusion on the SGPT as a measure of morbidity in Felis catus (domestic cats) undergoing right hepatic lobectomy. Nine male cats, weighing 2.5-5kg, are equally allocated into any one of the following 3 study groups: Control group not subjected to ischemic preconditioning (C), Experimental group subjected to 1 1/2 minutes of ischemia followed by 1.5 minutes of reperfusion (El), Experimental group subjected to 5 minutes of ischemia followed by 5 minutes of reperfusion (E2).
RESULTS: There was no significant difference in the mean weight of cats in the 3 groups (p = 1.00). Comparing the pre and post result between using paired t-test, there was no significant difference in the baseline values (p = 0.14). However, there was a significant difference in the post result between the three groups (p < 0.001). The results showed that the mean post values significantly increased from baseline. The same result was noted in the El and E2 group where a significant increase was also noted with p values, 0.005 and 0.004, respectively. Comparing the mean difference in the pre and post values using ANOV A, there was a significant difference noted between the three groups as proven by all p values
CONCLUSION: In the past few years, interesting new data on the presence of ischemic preconditioning in various organs as an endogenous means to protect itself from ischemiahas been available. This study investigated and suggests that ischemic preconditioning may provide protection to the liver undergoing hepatic lobectomy.

Animal ; Alanine Transaminase ; Felis ; Ischemic Preconditioning ; Hepatectomy ; Liver ; Cats