1.Essential tremor plus affects disease prognosis: A longitudinal study.
Runcheng HE ; Mingqiang LI ; Xun ZHOU ; Lanqing LIU ; Zhenhua LIU ; Qian XU ; Jifeng GUO ; Xinxiang YAN ; Chunyu WANG ; Hainan ZHANG ; Irene X Y WU ; Beisha TANG ; Sheng ZENG ; Qiying SUN
Chinese Medical Journal 2025;138(1):117-119
2.In Vitro and Animal Studies of Human Natural Killer Cell-Derived Exosomes for the Treatment of Otitis Media.
Zirui ZHAO ; Liqin WANG ; Zhen GUO ; Kanglun JIANG ; Jianghong XU ; Yilai SHU ; Christina Y XU ; Jianning ZHANG ; Yunfeng WANG ; Geng-Lin LI
Neuroscience Bulletin 2025;41(10):1792-1804
Otitis media is an infection of the middle ear mainly caused by bacteria, and current treatments rely heavily on antibiotics. However, the emergence of antibiotic-resistant bacterial strains seriously affects their efficacy. In our study, we found that extracellular vesicles (EVs) derived from human natural killer cells (NKs) inhibit the proliferation of both standard and levofloxacin (LVX)-resistant strains of Staphylococcus aureus in a dose-dependent manner. Moreover, compared to LVX, EVs were more effective at reducing effusion and rescuing hearing thresholds in animal models. For LVX-sensitive strains, EVs were significantly more effective in terms of curative time but not curative rate. For LVX-resistant strains, EVs were significantly more effective in terms of both curative rate and curative time when applied alone or applied jointly with LVX. In summary, we found that NK EVs are highly effective in treating otitis media, providing an alternative approach for treating this common disease.
Killer Cells, Natural/metabolism*
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Exosomes/metabolism*
;
Animals
;
Humans
;
Otitis Media/therapy*
;
Staphylococcus aureus/drug effects*
;
Disease Models, Animal
;
Anti-Bacterial Agents/pharmacology*
;
Levofloxacin/pharmacology*
4.Explanation and interpretation of the compilation of neonatal blood transfusion in the national health standard "Guideline for pediatric transfusion".
Rong GUI ; Rong HUANG ; Ming-Hua YANG ; Xiao-Fan ZHU ; Jun LU ; Xiao-Jun XU ; Tian-Ming YUAN ; Rong ZHANG ; Xu WANG ; Jin-Ping LIU ; Jing WANG ; Zhi-Li SHAO ; Ming-Yi ZHAO ; Yong-Jian GUO ; Jia-Rui CHEN ; Qi-Rong CHEN ; Jia GUO ; Xin-Yin WU ; Ming-Yan HEI ; Qing-Nan HE
Chinese Journal of Contemporary Pediatrics 2024;26(12):1249-1254
In order to guide clinical blood transfusion practices for pediatric patients, the National Health Commission has released the health standard "Guideline for pediatric transfusion" (WS/T 795-2022). Considering the physiological particularities of the neonatal period, blood transfusion practices for neonates are more complex than those for other children, the guidelines include a separate chapter dedicated to neonatal blood transfusion. This paper interprets the background and evidence for the compilation of the neonatal blood transfusion provisions, hoping to aid in the understanding and implementation of the neonatal blood transfusion section of the guidelines.
Humans
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Infant, Newborn
;
Blood Transfusion/standards*
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Practice Guidelines as Topic
8.The application of the non-woven fabric and filter paper "sandwich" fixation method in preventing the separation of the mucosal layer and muscular layer in mouse colon histopathological sections.
L SHEN ; Y T LI ; M Y XU ; G Y LIU ; X W ZHANG ; Y CHENG ; G Q ZHU ; M ZHANG ; L WANG ; X F ZHANG ; L G ZUO ; Z J GENG ; J LI ; Y Y WANG ; X SONG
Chinese Journal of Pathology 2023;52(10):1040-1043
10.Pulmonary anaplastic lymphoma kinase positive histiocytosis: report of a case.
W M XU ; Z R GAO ; X LI ; Y JIANG ; Q FENG ; L W RUAN ; Y Y WANG
Chinese Journal of Pathology 2023;52(11):1168-1170
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