ObjectiveTo explore the impact of intrauterine growth discordance on physical growth and development during infancy and early childhood in twins, and to provide an evidence-based basis for early childhood healthcare and clinical intervention. MethodsA retrospective cohort study design was adopted, with data sourced from the Yiwu Maternal and Child Health Information Platform, Zhejiang Province from January 2016 to July 2023. A total of 439 pairs of twins were included in the study. Generalized estimating equations (GEE) were used to analyze the association between twin growth discordance and weight, length, and head circumference within 36 months of age. ResultsAmong the 439 pairs of twins, 51 pairs (11.6%) exhibited intrauterine growth discordance. GEE analyses showed that the percentage difference of intrauterine growth discordance was negatively associated with weight (β=-0.013, P<0.001), length (β=-0.033, P<0.001), and head circumference (β=-0.015, P<0.001) within 36 months of age. Among the discordant pairs, the twin with the lower birth weight had a significantly higher risk of being classified as growth-retarded for weight (OR=6.057, 95%CI: 3.956‒9.274), length (OR=5.233, 95%CI: 3.499‒7.827), and head circumference (OR=3.476, 95%CI: 2.004‒6.031) during early childhood. ConclusionAmong twins with intrauterine growth discordance, the twin born with lower birth weight is a risk factor for growth retardation in weight, length, and head circumference during infancy and early childhood. It is suggested that an early identification mechanism should be established for such high-risk groups, dynamic monitoring should be implemented in clinical diagnosis and treatment as well as child health care services, and comprehensive measures such as personalized nutritional interventions should be taken as early as possible.

Objective To study formation of ammonion-magnesium phosphate crystals in urine with bacteria growing and provide guidance for cilinical prevention of urinary calculi.Methods Bacterial culturefluid of Escherichia coli,Proteus mirabilis,Pseudomonas aeruginosa,Klevsiella pneumoniae,Enterococcus in urine was examined directly under the ultrahigh sensitive microscpcope system for ammonion-magnesium phosphate crystasl.The number of ammonion-magnesium phosphate crystasl was measured when the 24th and the 48th hour.Results Ammonion-magnesium phosphate crystasl were observed from the culture fluid without ammonion magnesium phosphate crystasl.The rate of male formation was higher than that of female.Ammonion-magnesium phosphate crystals in culture fluid of Proteus mirabilis was the highest,Pseudomonasaeruginosa was the second,the third was Klebsiella pneumoniae,and there was formed 1 case in 2 ml culturefluid of enterococcus,and 2 cases of formation in 5 ml culturefluid of Escherichia coli.The crystals formed were the most unformed feather crystals,followed by cubic and square cylinders,an d the envelope like crystals were the least.Conclusion Bacteria with urease play a significant role in ammonion-magnesium phosphate crystasl formed,Proteus mirabilis is the main pathlogen.

In recent years,the application of haploidentical stem cell transplantation makes it possible for every transplant candidate to have a donor.Therefore,choosing best donor and dealing with transplantrelated complications,such as promoting engraftment,decreasing graft-versus-host disease and relapse,become key issues to improve transplant outcomes.The advances in allogeneic hematopoietic stem cell transplantation will be reviewed.

Three dimensional structure of the surface is an important factor that influences the mass transfer behavior of hemoglobin-based nanocapsule surface. In this paper, the modified double emulsion method was used to fabricate the blood substitute of hemoglobin-based nanocapsules, and with the use of different molecular weight of PEG as probes, the effects of different technical conditions (such as primary emulsion, double emulsion, polymer, solvent, et al) in the processing on the three dimensional structure of the nanocapsule surface were investigated in details. Researches indicated that the water-soluable solvent, such as ethyl acetate and acetone could effectively modulate the pore size of the nanocapsule surface. With the increasing of the ratio of water-soluble solvent, the pore size of the nanocapsules firstly increased and then decreased. The increasing of the extra-water volume, the prolongation of the solvent evaporation time, and the improvement of the stirring speed resulted in a bigger pore size, but the increasing of the solvent volume and PEG polymer could reduce the pore size of nanocapsule surface.
Acetone ; chemistry ; Animals ; Biocompatible Materials ; chemistry ; Blood Substitutes ; chemical synthesis ; chemistry ; metabolism ; Cattle ; Emulsions ; Hemoglobins ; chemistry ; Nanocapsules ; chemistry ; Porosity ; Solvents ; Surface Properties