Objective To investigate the clinical efficacy of triple-therapy combined with Chinese medicinal herbs in the treatment of helicobacter pylori-related peptic ulcer .Methods One hundred and fifty patients with Hp-related peptic ulcer hospitalized in the Department of Gastroenterology , Dongfeng Hospital Affiliated to Hubei Medical College , were randomly divided into 2 groups, each consisting of 75 patients.The control group received conventional triple-therapy, while the treatment group was given Chinese me-dicinal herbs on the basis of triple-therapy .Therapeutic effect , Hp eradication rate , recurrence rate and adverse reactions were com-pared between the 2 groups.Results After treatment, total scores of TCM syndrome in the treatment group were significantly lower than those of the control group (P<0.05).The eradication rate of Hp in the treatment group was 82.67%, which was significantly higher than 61.33% in the control group , and statistical significance could be noticed , when comparisons were made between them ( P<0.05 ) .The total effective rate of the treatment group was significantly higher than that of the control group , and the recurrence rate was significantly lower than that of the control group (P<0.05).Conclusion Triple-therapy combined with Chinese medicinal herbs in the treatment of Hp-related peptic ulcer could effectively improve clinical symptoms , eliminate Hp and reduce the risk of recurrence .