Objective To explore the correlation between the levels of serum circUSP36 and circBPTF in patients with diabetic retinopathy(DR)and the severity of the disease.Methods Totally 175 DR patients who visited Luzhou People's Hospital from January 2022 to October 2024 were selected as the research sub-jects.According to the international clinical DR classification standard,they were divided into the non-signifi-cant DR group(NDR group),non-proliferative DR group(NPDR group),and proliferative DR group(PDR group),with 72 cases in the NDR group,63 cases in the NPDR group,and 40 cases in the PDR group.Another 50 healthy individuals who underwent physical examinations during the same period were selected as the con-trol group.The levels of serum circUSP36 and circBPTF in each group were determined by fluorescence quan-titative PCR.The correlation between the expression levels of serum circUSP36 and circBPTF in patients of the PDR group was analyzed by Pearson method.Logistic regression analysis was used to analyze the factors of DR.Receiver operating characteristic(ROC)curve was used to analyze the evaluation value of the expres-sion levels of serum circUSP36 and circBPTF in DR patients for the severity of DR.Results There were sta-tistically significant differences in the levels of circUSP36,circBPTF,fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 hPG),glycated hemoglobin(HbA1c)between the NDR group,the NPDR group,the PDR group and the control group(P＜0.05).The levels of circUSP36,circBPTF,FPG,2 hPG and HbA1c increased with the severity of DR(P＜0.05).The expression levels of serum circUSP36 and circBPTF in patients of the PDR group were positively correlated(r=0.441,P=0.004).The duration of T2DM,high circUSP36,and high circBPTF were all independent risk factors for PDR(P＜0.05).The area under the curve(AUC)of serum circUSP36 and circBPTF alone and in combination for predicting NPDR were 0.678,0.698,and 0.775,respectively,and the predictive value of the combination of serum circUSP36 and circBPTF was su-perior to that of their individual detections(P＜0.05).The AUCs of serum circUSP36 and circBPTF alone and in combination for predicting PDR were 0.788,0.787,and 0.859,respectively,and the combination of the two was superior to their individual detections(P＜0.05).Conclusion The levels of serum circUSP36 and circBPTF are elevated in DR patients,and with the aggravation of DR,the expression levels of both show an upward trend.The combined detection of the two has certain predictive value for the severity of DR.

Objective To discuss the aetiological agent,prevention and treatment of the ureteroscopy lithotripsy concurrence urosepsis.Methods Retrospective analysis of 180 cases with ureteroscopy lithotripsy postoperative clinical data of 8 cases in urosepis patients.Results Eight patients with early active anti-infection,anti-shock treatment,eight patients were recovered and discharged,curative effect is satisfied.Conclusion Ureteroscopy lithotripsy postoperative patients concurrent urosepsis is dangerous,early detection,early diagnosis,early treatment is the key.