Objective To investigate the effect of Clearing and Elimination Therapy combined with small incision lesion resection in treating granulomatous lobular mastitis(GLM).Methods The medical re-cord data of 160 female patients with pathologically diagnosed GLM receiving Clearing and Elimination Thera-py combined with small incision lesion resection in the Department of Integrated Chinese Traditional and Western Medicine Mammary Gland of this hospital from January 2019 to June 2023 were analyzed retrospec-tively.The disease course,cure rate and recurrence rate were observed and summarized.Results The total treatment course was(5.6±4.1)months.The cure rates after 3,6,12 months of treatment were 34.4%(55/160),58.1%(93/160)and 93.8%(150/160)respectively.The recurrence rates after 3,6,12 months of follow-up were 3.1%(5/160),3.8%(6/160)and 5.6%(9/160)respectively.Conclusion Clearing and Elimination Therapy combined with small incision lesion resection in treating GLM has good efficacy.