Objective:To describe the characteristics of human papillomavirus infection and thinprep cytologic test (TCT) outcome in health check-up females in Shenzhen.Methods:Use cross-sectional design, collect information from data from health check-up females in Shenzhen and describe characteristics of HPV infections screening and TCT outcomes.Results:We collected the data of 75 754 females, 103 508 females and 69 964 females received HPV detection, TCT and combined detection respectively. HPV standardized infection rate was 19.89% (95% CI: 19.45%-20.33%) and showed a "U-shaped" pattern in age distribution. The most prevalent HPV genotypes were 52, 51, 16, 58 and 53. Infection rate was higher for high-risk HPV than low-risk HPV genotype. Single infection was more common than its multiple infection. In addition, 7.48% (95% CI: 7.22%-7.75%) women were TCT positive, of whom 4.58% (95% CI: 4.40%-4.76%), 2.54% (2.40%-2.69%), 0.27% (95% CI: 0.23%-0.31%) had atypical squamous cells, low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial lesions, respectively. Overall and subtype HPV infection rates increased with severity of abnormal cervical cytology. The most prevalent HPV genotypes were 52, 58 and 16 in women with abnormal cervical cytology. Conclusions:HPV prevalence remains at a high level in Shenzhen. This study suggests that attention should be paid to HPV screening, especially in young, perimenopausal women and in high risk HPV genotype infection. Timely follow-up and cervical cytology screening are required for women with high-risk HPV infection or persistent infection. Future vaccination strategies should take account of prevalent HPV genotype.

Objective:To analyze the results of TORCH screening for reproductive-age females who underwent pre-pregnancy health examination in Shenzhen to guide scientific pregnancy preparation.Methods:Cross-sectional study was performed on the TORCH screening results of 330 115 reproductive-age females who participated in free pre-pregnancy health examination in Shenzhen from January, 2013 to December, 2019. The χ2 test was used to analyze the differences of TORCH screening results among reproductive-age females in different years, administrative regions and demographic characteristics. Results:The overall positive rates of screening for rubella virus (RV)-IgG, cytomegalovirus (CMV)-IgG, CMV-IgM, toxoplasma gondii (TOX)-IgG and TOX-IgM among reproductive-age females in Shenzhen were 85.54% (282 377/330 115), 96.36% (318 088/330 115), 0.31% (1009/330 115), 3.12% (10 292/330 115) and 0.64% (2114/330 115), respectively. Compared with 2013 to 2016, the average positive rates of RV-IgG and CMV-IgG among reproductive-age females in Shenzhen increased ( P=0.003, P<0.001), while the average positive rates of TOX-IgG and TOX-IgM decreased from 2017 to 2019 ( P<0.001). There were statistically significant differences in the positive rates of the five antibodies among different administrative regions (all P<0.001). Except for the differences in the positive rates of CMV-IgM and TOX-IgM among women of different ages, there were statistically significant differences in the positive rates of these five antibodies among reproductive-age females with other demographic characteristics (all P<0.05). There were statistical differences in the positive rates of TORCH antibodies among women with different demographic characteristics in different years. Conclusion:Compared with 2013 to 2016, the positive rates of RV-IgG and CMV-IgG in reproductive-age females in Shenzhen from 2017 to 2019 were on the rise, while the positive rates of TOX-IgG and TOX-IgM were on the decline. The positive rates of these five antibodies were different among different administrative regions and among reproductive-age females with different demographic characteristics, which suggested that plans should be made according to local conditions and different objects in order to strengthen the awareness of eugenics and reduce the risk of congenital intrauterine infection with TORCH of the fetus during the propaganda and education of eugenics.

Objective:To analyze the results of TORCH screening for reproductive-age females who underwent pre-pregnancy health examination in Shenzhen to guide scientific pregnancy preparation.Methods:Cross-sectional study was performed on the TORCH screening results of 330 115 reproductive-age females who participated in free pre-pregnancy health examination in Shenzhen from January, 2013 to December, 2019. The χ2 test was used to analyze the differences of TORCH screening results among reproductive-age females in different years, administrative regions and demographic characteristics. Results:The overall positive rates of screening for rubella virus (RV)-IgG, cytomegalovirus (CMV)-IgG, CMV-IgM, toxoplasma gondii (TOX)-IgG and TOX-IgM among reproductive-age females in Shenzhen were 85.54% (282 377/330 115), 96.36% (318 088/330 115), 0.31% (1009/330 115), 3.12% (10 292/330 115) and 0.64% (2114/330 115), respectively. Compared with 2013 to 2016, the average positive rates of RV-IgG and CMV-IgG among reproductive-age females in Shenzhen increased ( P=0.003, P<0.001), while the average positive rates of TOX-IgG and TOX-IgM decreased from 2017 to 2019 ( P<0.001). There were statistically significant differences in the positive rates of the five antibodies among different administrative regions (all P<0.001). Except for the differences in the positive rates of CMV-IgM and TOX-IgM among women of different ages, there were statistically significant differences in the positive rates of these five antibodies among reproductive-age females with other demographic characteristics (all P<0.05). There were statistical differences in the positive rates of TORCH antibodies among women with different demographic characteristics in different years. Conclusion:Compared with 2013 to 2016, the positive rates of RV-IgG and CMV-IgG in reproductive-age females in Shenzhen from 2017 to 2019 were on the rise, while the positive rates of TOX-IgG and TOX-IgM were on the decline. The positive rates of these five antibodies were different among different administrative regions and among reproductive-age females with different demographic characteristics, which suggested that plans should be made according to local conditions and different objects in order to strengthen the awareness of eugenics and reduce the risk of congenital intrauterine infection with TORCH of the fetus during the propaganda and education of eugenics.

Objective To understand AIDS related knowledge and behaviors among female sex workers(FSWs) and their male clients from the same community.Methods One hundred and seventy seven FSWs and one hundred and fifty four male clients were recruited from entertainment venues in the same community by random sampling,and anonymous questionnaires were administered separately.Results(1)Over 80% of FSWs and their male clients understood the basic routes of HIV transmission,but many of them were unclear about non-HIV transmission routes.(2)97.7% of FSWs and 84.2% of the male clients used condoms during their commericial sexual intercourse.The frequency of using condoms during sex with casual or regular sex partners was lower than that during the commercial sexual intercourse(P