1.Research progress of ETS-1 in inflammatory bowel disease and colitis-associated colorectal cancer
Xufan SUN ; Guiyuan JIN ; Cuimei MA ; Yan WANG ; Huihui ZHOU ; Guangxi ZHOU
Chinese Journal of Inflammatory Bowel Diseases 2024;08(2):164-168
ETS proto-oncogene 1 (ETS-1) is a member of ETS transcription factor family and plays essential roles in tumorigenesis and inflammation. ETS-1 promotes the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) by inducing inflammation, destroying the intestinal epithelial cell barrier, and increasing the invasiveness of cancer cells. This article reviews the research progress of ETS-1 in IBD and CAC in order to investigate the pathogenesis and underlying treatment targets of IBD and CAC.
2.Research progress of ETS-1 in inflammatory bowel disease and colitis-associated colorectal cancer
Xufan SUN ; Guiyuan JIN ; Cuimei MA ; Yan WANG ; Huihui ZHOU ; Guangxi ZHOU
Chinese Journal of Inflammatory Bowel Diseases 2024;08(2):164-168
ETS proto-oncogene 1 (ETS-1) is a member of ETS transcription factor family and plays essential roles in tumorigenesis and inflammation. ETS-1 promotes the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) by inducing inflammation, destroying the intestinal epithelial cell barrier, and increasing the invasiveness of cancer cells. This article reviews the research progress of ETS-1 in IBD and CAC in order to investigate the pathogenesis and underlying treatment targets of IBD and CAC.
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