[Objective]To analyze the application and compatibility rules of acupoints and reflex areas in foot massage for the treatment of insomnia through data mining technology,thereby providing an evidence-based basis for the clinical treatment of foot massage in patients with insomnia.[Methods]The literatures associated with the treatment of insomnia through foot massage were retrieved by computer from The Cochrane Library,Web of Science,Embase,PubMed,China National Knowledge Infrastructure,Wanfang,VIP,Chinese Biomedical Literature and other databases.The search period was set until January 1,2025.Excel 2016 software was employed to establish the database for the treatment of insomnia with foot massage,and SPSS 25.0 software was utilized to calculate the frequency of acupoints and reflection areas in the database.Association rules were analyzed by the Apriori module of SPSS Modeler 18.0 software.The association rules of acupoints,reflection areas and their compatibility were described.The association rules were visualized by using Cytoscape 3.9.1 and cluster analysis was visualized with Origin 2022,respectively.[Results]Finally,124 effective literatures were incorporated including 35 for massage treatment of the foot reflex area alone,42 for massage treatment of the foot point alone,and 47 for massage treatment of the combined area and point.The most frequently utilized foot reflex areas of foot massage were the brain,the abdominal nerve plexus,the kidney,the heart,etc.,and the foot points were Yongquan,insomnia points,Taixi,etc.,among which the foot points were mainly characterized by the foot Shaoyin kidney channel and the foot Jueyin liver channel.The five transport points were the most prevalent specific points.The statistical results indicated that the effect of multi-point and/or multi-zone compatibility treatment was superior.Compatibility analysis revealed that the efficacy of multi-point and/or multi-zone compatibility treatments was superior.Analysis result of 124 articles on insomnia treatment through foot massage demonstrated that the most supportive compatibitily for the treatment of insomnia by foot massage was brain-abdominal nerve plexus,which was consistent with the analysis results of 35 literatures on the treatment of insomnia by foot reflex area massage alone.Furthermore,an analysis of 42 articles on insomnia treatment through massage of foot acupoints indicated that Yongquan-Taixi was the most supportive foot acupoint combination.[Conclusion]The combination of Chinese and western medicine theories for guiding foot massage in the treatment of insomnia is highly recommended.Selecting points such as Yongquan,Taixi,insomnia points,brain,abdominal nerve plexus,kidney,heart,and others for the compatibility treatment effect of these areas is better.

Objective:To investigate and analyze the thyroid examination results and influencing factors of interventional radiation workers in Tianjin.Methods:In February 2023, A convenient sampling method was used to select the staff engaged in interventional radiation work in an occupational health inspection institution in Tianjin from 2020 to 2022 as the study object. After excluding the incomplete data, 1080 people were included, and 363 medical staff with non-radiological work during the same period were included as the control group. To analyze the individual doses and occupational health examination data of interventional radiation workers, and to analyze the possible influencing factors of thyroid abnormalities.Results:The cumulative dose M ( Q1, Q3) of interventional radiation workers was 1.039 (0.528, 1.905) mSv. The levels of FT 3 and FT 4 in the intervention group were higher than those in the control group, while TSH levels were lower than those in the control group ( Z=4.84、6.03、-5.82, P<0.05). The levels of FT 3 and FT 4 in female interventional radiation workers were lower than those in males, while the levels of TSH were higher than those in males ( Z= -17.54、-6.65、3.61, P<0.05). There were statistically significant differences in FT 3 levels among different ages, differen tradiation exposure years, different initial age of exposure to radiation, and different cumulative doses ( H=47.22、11.33、16.70, Z=-2.48, P<0.05). There were statistically significant differences in thyroid ultrasound abnormalities among different genders, different ages, different initial age of exposure to radiation, and different cumulative doses ( χ2=28.02、61.12、17.87、11.30, P<0.05). The results of logistic regression analysis showed that the influencing factors of FT 3 distributed in the low-level group were female ( OR=10.53, 95% CI: 7.66-14.47, P<0.05), and age 40-49, ≥50 years old ( OR=2.40, 95% CI: 1.12-5.14 OR=3.79, 95% CI: 1.59-9.03, P<0.05). The influencing factors of thyroid ultrasound abnormalities were female ( OR=1.92, 95% CI: 1.48-2.50, P<0.05) and age ≥50 years old ( OR=3.93, 95% CI: 1.91-8.09, P<0.05) . Conclusion:Long term low dose ionizing radiation has a certain effect on FT 3, FT 4 and TSH levels of interventional radiation workers. Gender and increased age are possible influencing factors of the decreased FT 3 levels and thyroid ultrasound abnormalities.

Objective To explore the application effect of foot massage based on the brain-gut axis theory in patients with spleen-kidney yang deficiency syndrome undergoing maintenance hemodialysis and suffering from insomnia,and to provide references for improving patients' sleep quality and gastrointestinal symptoms.Methods A total of 88 patients with spleen-kidney yang deficiency syndrome undergoing maintenance hemodialysis and suffering from insomnia,who were treated at a Blood Purification Center of a tertiary-A general hospital in Hangzhou,Zhejiang Province from April to September 2024,were selected as a study subjects.They were randomly divided into an experimental group and a control group using the random number table method,with 44 cases in each group.The experimental group received foot massage based on the guidance of the brain-gut axis theory in addition to conventional treatment and nursing care,while the control group received conventional treatment and nursing care only.The intervention lasted for 3 months.The differences in the Pittsburgh Sleep Quality Index(PSQI)scores,Gastrointestinal Symptom Rating Scale(GSRS)scores,traditional Chinese medicine(TCM)syndrome scores,and serum 5-hydroxytryptamine and melatonin levels between the 2 groups before and after the intervention were compared.Results During the study period,no cases were lost in the experimental group,while 5 cases were lost in the control group.Ultimately,44 cases were included in the experimental group and 39 cases in the control group.After the intervention,the PSQI scores,GSRS scores,and TCM syndrome scores in both groups were lower than those before the intervention,and those in the experimental group were lower than those in the control group.The serum 5-hydroxytryptamine and melatonin levels were higher than those before the intervention,and the levels in the experimental group were higher than those in the control group,with statistically significant differences(all P＜0.001).Conclusion Foot massage based on the brain-gut axis theory can improve gastrointestinal symptoms and TCM syndromes in patients with spleen-kidney yang deficiency syndrome undergoing maintenance hemodialysis and suffering from insomnia,and enhance their sleep quality.

Objective:To investigate and analyze the thyroid examination results and influencing factors of interventional radiation workers in Tianjin.Methods:In February 2023, A convenient sampling method was used to select the staff engaged in interventional radiation work in an occupational health inspection institution in Tianjin from 2020 to 2022 as the study object. After excluding the incomplete data, 1080 people were included, and 363 medical staff with non-radiological work during the same period were included as the control group. To analyze the individual doses and occupational health examination data of interventional radiation workers, and to analyze the possible influencing factors of thyroid abnormalities.Results:The cumulative dose M ( Q1, Q3) of interventional radiation workers was 1.039 (0.528, 1.905) mSv. The levels of FT 3 and FT 4 in the intervention group were higher than those in the control group, while TSH levels were lower than those in the control group ( Z=4.84、6.03、-5.82, P<0.05). The levels of FT 3 and FT 4 in female interventional radiation workers were lower than those in males, while the levels of TSH were higher than those in males ( Z= -17.54、-6.65、3.61, P<0.05). There were statistically significant differences in FT 3 levels among different ages, differen tradiation exposure years, different initial age of exposure to radiation, and different cumulative doses ( H=47.22、11.33、16.70, Z=-2.48, P<0.05). There were statistically significant differences in thyroid ultrasound abnormalities among different genders, different ages, different initial age of exposure to radiation, and different cumulative doses ( χ2=28.02、61.12、17.87、11.30, P<0.05). The results of logistic regression analysis showed that the influencing factors of FT 3 distributed in the low-level group were female ( OR=10.53, 95% CI: 7.66-14.47, P<0.05), and age 40-49, ≥50 years old ( OR=2.40, 95% CI: 1.12-5.14 OR=3.79, 95% CI: 1.59-9.03, P<0.05). The influencing factors of thyroid ultrasound abnormalities were female ( OR=1.92, 95% CI: 1.48-2.50, P<0.05) and age ≥50 years old ( OR=3.93, 95% CI: 1.91-8.09, P<0.05) . Conclusion:Long term low dose ionizing radiation has a certain effect on FT 3, FT 4 and TSH levels of interventional radiation workers. Gender and increased age are possible influencing factors of the decreased FT 3 levels and thyroid ultrasound abnormalities.

[Objective]To analyze the application and compatibility rules of acupoints and reflex areas in foot massage for the treatment of insomnia through data mining technology,thereby providing an evidence-based basis for the clinical treatment of foot massage in patients with insomnia.[Methods]The literatures associated with the treatment of insomnia through foot massage were retrieved by computer from The Cochrane Library,Web of Science,Embase,PubMed,China National Knowledge Infrastructure,Wanfang,VIP,Chinese Biomedical Literature and other databases.The search period was set until January 1,2025.Excel 2016 software was employed to establish the database for the treatment of insomnia with foot massage,and SPSS 25.0 software was utilized to calculate the frequency of acupoints and reflection areas in the database.Association rules were analyzed by the Apriori module of SPSS Modeler 18.0 software.The association rules of acupoints,reflection areas and their compatibility were described.The association rules were visualized by using Cytoscape 3.9.1 and cluster analysis was visualized with Origin 2022,respectively.[Results]Finally,124 effective literatures were incorporated including 35 for massage treatment of the foot reflex area alone,42 for massage treatment of the foot point alone,and 47 for massage treatment of the combined area and point.The most frequently utilized foot reflex areas of foot massage were the brain,the abdominal nerve plexus,the kidney,the heart,etc.,and the foot points were Yongquan,insomnia points,Taixi,etc.,among which the foot points were mainly characterized by the foot Shaoyin kidney channel and the foot Jueyin liver channel.The five transport points were the most prevalent specific points.The statistical results indicated that the effect of multi-point and/or multi-zone compatibility treatment was superior.Compatibility analysis revealed that the efficacy of multi-point and/or multi-zone compatibility treatments was superior.Analysis result of 124 articles on insomnia treatment through foot massage demonstrated that the most supportive compatibitily for the treatment of insomnia by foot massage was brain-abdominal nerve plexus,which was consistent with the analysis results of 35 literatures on the treatment of insomnia by foot reflex area massage alone.Furthermore,an analysis of 42 articles on insomnia treatment through massage of foot acupoints indicated that Yongquan-Taixi was the most supportive foot acupoint combination.[Conclusion]The combination of Chinese and western medicine theories for guiding foot massage in the treatment of insomnia is highly recommended.Selecting points such as Yongquan,Taixi,insomnia points,brain,abdominal nerve plexus,kidney,heart,and others for the compatibility treatment effect of these areas is better.

Objective To explore the application effect of foot massage based on the brain-gut axis theory in patients with spleen-kidney yang deficiency syndrome undergoing maintenance hemodialysis and suffering from insomnia,and to provide references for improving patients' sleep quality and gastrointestinal symptoms.Methods A total of 88 patients with spleen-kidney yang deficiency syndrome undergoing maintenance hemodialysis and suffering from insomnia,who were treated at a Blood Purification Center of a tertiary-A general hospital in Hangzhou,Zhejiang Province from April to September 2024,were selected as a study subjects.They were randomly divided into an experimental group and a control group using the random number table method,with 44 cases in each group.The experimental group received foot massage based on the guidance of the brain-gut axis theory in addition to conventional treatment and nursing care,while the control group received conventional treatment and nursing care only.The intervention lasted for 3 months.The differences in the Pittsburgh Sleep Quality Index(PSQI)scores,Gastrointestinal Symptom Rating Scale(GSRS)scores,traditional Chinese medicine(TCM)syndrome scores,and serum 5-hydroxytryptamine and melatonin levels between the 2 groups before and after the intervention were compared.Results During the study period,no cases were lost in the experimental group,while 5 cases were lost in the control group.Ultimately,44 cases were included in the experimental group and 39 cases in the control group.After the intervention,the PSQI scores,GSRS scores,and TCM syndrome scores in both groups were lower than those before the intervention,and those in the experimental group were lower than those in the control group.The serum 5-hydroxytryptamine and melatonin levels were higher than those before the intervention,and the levels in the experimental group were higher than those in the control group,with statistically significant differences(all P＜0.001).Conclusion Foot massage based on the brain-gut axis theory can improve gastrointestinal symptoms and TCM syndromes in patients with spleen-kidney yang deficiency syndrome undergoing maintenance hemodialysis and suffering from insomnia,and enhance their sleep quality.

Objective:To analyze and study the difficulties and countermeasures in the implementation of the Qualified Person(QP) system for stem cell clinical research, and share the experience of QP management practice in our hospital in order to promote and improve the construction of the QP management system in medical institutions.Methods:Comprehensive investigations were conducted to summarize and analyze the shortage of talents, unclear qualifications, unclear responsibilities, and lack of assessment standards in the QP system of medical institutions.Results:In view of the difficulties in the implementation of the current QP system, it is suggested to consider a combination of improving the system of laws and regulations, strengthening the top-level design of stem cell research institutions, clarifying the qualification threshold, refining QP responsibilities, continuing training and assessment system, establishing QP support system, etc.Conclusions:Medical institutions are responsible for stem cell clinical research, and the improvement of the QP system can promote the development of the cell industry in China.

Objective::Microchannels are associated with the progression of atherosclerotic vulnerable plaques. However, in patients with culprit optical coherence tomography (OCT)-defined plaque erosion, the knowledge of microchannels and culprit lesion vulnerability is limited. The aim of this study was to investigate culprit lesion characteristics in patients with ST-segment elevated myocardial infarction (STEMI) caused by plaque erosion with and without microchannels using OCT.Methods::In all, 348 STEMI patients with plaque erosion who underwent OCT of the culprit lesion at the 2 nd Affiliated Hospital of Harbin Medical University (Harbin, China) from August 2014 to December 2017 were included and divided into the microchannel group ( n= 116, 33.3%) and no-microchannel group ( n = 232, 66.7%). The clinical characteristics and OCT-derived plaque features were compared between both groups. Results::Among the 348 STEMI patients with plaque erosion, culprit lesions with microchannels had higher incidence of lipid plaque (59.5% vs. 45.3%, P= 0.012); calcification (41.4% vs. 24.6%, P= 0.002); spotty calcification (30.2% vs. 18.1%, P= 0.014); macrophages accumulation (72.4% vs. 45.7%, P < 0.001); and cholesterol crystals (32.8% vs. 14.2%, P < 0.001) than those without microchannels. In addition, minimal lumen area was smaller ((1.9 ± 0.9) mm 2vs. (2.8 ± 2.3) mm 2, P < 0.001) and lumen area stenosis was greater ((71.3% ± 13.4%) vs. (65.3% ± 19.3%), P= 0.001) in the microchannel group than in the no-microchannel group. Conclusion::In patients with STEMI caused by plaque erosion, one-third manifested typical microchannel characteristics, and those with microchannels were associated with more severe luminal stenosis and more vulnerable plaque features than those without microchannels.

Objective::Microchannels are associated with the progression of atherosclerotic vulnerable plaques. However, in patients with culprit optical coherence tomography (OCT)-defined plaque erosion, the knowledge of microchannels and culprit lesion vulnerability is limited. The aim of this study was to investigate culprit lesion characteristics in patients with ST-segment elevated myocardial infarction (STEMI) caused by plaque erosion with and without microchannels using OCT.Methods::In all, 348 STEMI patients with plaque erosion who underwent OCT of the culprit lesion at the 2 nd Affiliated Hospital of Harbin Medical University (Harbin, China) from August 2014 to December 2017 were included and divided into the microchannel group ( n= 116, 33.3%) and no-microchannel group ( n = 232, 66.7%). The clinical characteristics and OCT-derived plaque features were compared between both groups. Results::Among the 348 STEMI patients with plaque erosion, culprit lesions with microchannels had higher incidence of lipid plaque (59.5% vs. 45.3%, P= 0.012); calcification (41.4% vs. 24.6%, P= 0.002); spotty calcification (30.2% vs. 18.1%, P= 0.014); macrophages accumulation (72.4% vs. 45.7%, P < 0.001); and cholesterol crystals (32.8% vs. 14.2%, P < 0.001) than those without microchannels. In addition, minimal lumen area was smaller ((1.9 ± 0.9) mm 2vs. (2.8 ± 2.3) mm 2, P < 0.001) and lumen area stenosis was greater ((71.3% ± 13.4%) vs. (65.3% ± 19.3%), P= 0.001) in the microchannel group than in the no-microchannel group. Conclusion::In patients with STEMI caused by plaque erosion, one-third manifested typical microchannel characteristics, and those with microchannels were associated with more severe luminal stenosis and more vulnerable plaque features than those without microchannels.

Objective:To investigate the prevalence of Work-related musculoskeletal disorders(WMSDs) and identify associated risk factors and provide evidence of taking measures for prevention.Methods:By Cluster sampling, 1 920 employees of 35 manufacturing enterprises were selected as study subjects from May to December 2017. The questionnnaire were including population characteristics、related factors of ergonomics、job burnout、insomnia and WMSDs.Results:The prevalence of waist was the highest among 9 body parts, with 52.0%, followed by the prevalence of neck 50.6%, more than 1 muscle diseases were by the prevalence of 74.7%. Single factor analysis showed that different levels of labor intensity, daily standing time (h) , daily sitting time(h) , daily bending time (h) , daily lifting of 5kg object time (h) group waist disease and prevalence of more than one musculoskeletal disease were different, The difference was statistically sig- nificant ( P<0.05). More than 5 years of working year, labor intensity of Class III, daily bending time ≥2 h, depression, disorders ( P<0.05). life satisfaction, job burnout, and insomnia are all risk factors for waist and musculoskeletal. The daily sitting time ≥2 h and the high life satisfaction were protective factors for waist and WMSDs ( P<0.05). Conclusion:The prevalence rate of WMSDs among manufacturing workers is strong, and Manager should take the aspects of ergonomics and psychological factors meassure to reduce WMSDs, These meassure were including increasing sitting time, reducing bending time.