Objective To investigate the effects of different doses of recombinant human growth hormone(rhGH)on idiopathic short stature in boys and its impact on serum metabolic biomarkers,insulin-like growth factor 1(IGF-1),and insulin-like growth factor binding protein 3(IGFBP-3).Methods Eighty boys with idiopathic short stature who were admitted to Jiangyin Hospital of Traditional Chinese Medicine from April 2020 to April 2023 were enrolled.They were assigned to low-dose group(0.26 mg/kg per week,n=29),medium-dose group(0.35 mg/kg per week,n=27),and high-dose group(0.41 mg/kg per week,n=24)according to the therapeutic dose of rhGH.The treatment lasted for 1-2 years.Height,weight,growth velocity,height standard score,bone density,bone age,bone metabolisms(serum 25-hydroxyvitamin D[25(OH)-D],bone alkaline phosphatase[BAP],and osteocalcin[OC]),thyroid function(free triiodothyronine[FT3],free thyroxine[FT4],and thyroid-stimulating hormone[TSH]),IGF-1,and IGFBP-3 were compared among groups before and after treatment.Results The height,weight,growth velocity,height standard score,bone density,and bone age were increased in all the three groups after treatment(PTime<0.05).Serum 25(OH)-D,BAP,and osteocalcin were also significantly increased(PGroup<0.05,PTime<0.05).As the treatment progressed,serum IGF-1 and IGFBP-3 levels increased(PTime<0.05).The incidence of adverse reaction(joint pain,injection site edema,and hyperglycemia)in the high-dose group(25.00%)was higher than that in the low-dose group(13.79%)and medium-dose group(18.52%).Conclusion Medium and high doses of rhGH can more effectively improve bone density,serum IGF-1,and IGFBP-3 in boys with idiopathic short stature.It is recommended to choose an appropriate dose of rhGH based on the specific condition of boys with idiopathic short stature under the precondition of safety.

Podocalyxin,a sialomucin most closely related to CD34,is expressed by kidney podocytes,hematopoietic progenitors,vascular endóthelia and a subset of neurons.As one of the important apical marker protein,podocalyxin plays an important role in the integrity of the structure and function of nomal podocyte,and is closely related to the prevention of proteinuria.The mechanism of podocyte injury associated with proteinuria remains unkown.The investigation of podocalyxin,a major podocyte protein,is significant in the pathogenesis and process of the primarily glomerulopathies.This paper summarizes the progresses of podocalyxin in podocyte injury of proteinuria associated nephropathy.