Chronic diseases have become one of the major threats to human health. Health information-seeking behavior plays a positive role in effectively managing the health status of chronic disease patients and enhancing their self-management capabilities. This article summarizes the concept, assessment tools, current status, and influencing factors of health information-seeking behavior among chronic disease patients. It provides strategies and suggestions to offer references for developing intervention strategies for chronic disease patients' health information-seeking behavior.

Chronic diseases have become one of the major threats to human health. Health information-seeking behavior plays a positive role in effectively managing the health status of chronic disease patients and enhancing their self-management capabilities. This article summarizes the concept, assessment tools, current status, and influencing factors of health information-seeking behavior among chronic disease patients. It provides strategies and suggestions to offer references for developing intervention strategies for chronic disease patients' health information-seeking behavior.

OBJECTIVE: To filtrate and prove the different microRNAs (miRs) profiles in nasopharyngeal carcinoma. METHOD: Screening the different expressions of miRs between nasopharyngeal carcinoma and the inflammatory tissues by the application of expression profiling of chip high-throughput and large-scale microarray analysis. Then we used RT-QPCR technology to prove the accuracy of screening results. RESULT: There were significant expression differences of miRs between nasopharyngeal carcinoma and the control tissues, 144 human miRs had 2 or more fold the difference ratio. Compared with the inflammatory tissues, we have found that miRs-34b, miRs-449b and miRs-7-1 significantly low expressed in nasopharyngeal carcinoma, yet miRs-125b, miRs-184, miRs-196b, miRs-205 and miRs-24-1 expressed high. The results were consistent with the microarray analysis. CONCLUSION The difference expressed miRs might be closely related to the process of nasopharyngeal carcinoma, and the research on miRs profiles maybe provide a powerful target basis for early diagnosis and therapy of nasopharyngeal carcinoma.
Carcinoma ; Gene Expression Profiling ; Humans ; MicroRNAs ; genetics ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms ; genetics ; Oligonucleotide Array Sequence Analysis