Objective:To conduct a comprehensive global review of research on toxic leadership behavior among nursing managers and to analyze the current research status.Methods:Literature related to toxic leadership behavior among nursing managers was retrieved from PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, VIP Chinese Science and Technology Journal Database, and China Biomedical Literature Database. The search period extended from the inception of each database to February 15, 2025. The included literature was then organized, analyzed, and summarized.Results:A total of 28 studies were included. There were 23 studies reported the occurrence of toxic leadership behavior among nursing managers, the incidence of toxic leadership behavior was almost at a moderately low level. There were 8 studies reported the influencing factors of toxic leadership behavior, its influencing factors encompassed three primary aspects: the organizational level, the personal characteristics of nursing managers, and characteristics of the nursing staff group. Assessment tools of toxic leadership behavior included the Toxic Leadership Behaviors of Nurse Managers, the Abuse Management Questionnaire, etc. The adverse consequences included increased nurse turnover intention, decreased nursing quality, and reduced organizational trust, etc. Interventions were planned and implemented from three perspectives: the hospital managers, nursing managers, and the nurses.Conclusions:The factors influencing toxic leadership behavior among nursing managers and its adverse consequences require further exploration. Therefore, more intervention studies are warranted to provide new insights and methods for preventing and reducing toxic leadership behavior.

Objective:To conduct a comprehensive global review of research on toxic leadership behavior among nursing managers and to analyze the current research status.Methods:Literature related to toxic leadership behavior among nursing managers was retrieved from PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, VIP Chinese Science and Technology Journal Database, and China Biomedical Literature Database. The search period extended from the inception of each database to February 15, 2025. The included literature was then organized, analyzed, and summarized.Results:A total of 28 studies were included. There were 23 studies reported the occurrence of toxic leadership behavior among nursing managers, the incidence of toxic leadership behavior was almost at a moderately low level. There were 8 studies reported the influencing factors of toxic leadership behavior, its influencing factors encompassed three primary aspects: the organizational level, the personal characteristics of nursing managers, and characteristics of the nursing staff group. Assessment tools of toxic leadership behavior included the Toxic Leadership Behaviors of Nurse Managers, the Abuse Management Questionnaire, etc. The adverse consequences included increased nurse turnover intention, decreased nursing quality, and reduced organizational trust, etc. Interventions were planned and implemented from three perspectives: the hospital managers, nursing managers, and the nurses.Conclusions:The factors influencing toxic leadership behavior among nursing managers and its adverse consequences require further exploration. Therefore, more intervention studies are warranted to provide new insights and methods for preventing and reducing toxic leadership behavior.

Objective To investigate the clinical efficacy of interesting respiratory rehabilitation training(IRRT)combined with budesonide and montelukast sodium in the treatment of bronchial asthma(BA).Methods This is a pilot clinical research.Children with BA who visited Ma'anshan Shiqiye Hospital of Anhui province from January 2023 to December 2023 in were prospectively recruited as study subjects,and were divided into the IRRT group and the conventional group according to the random number table method.After 8 weeks of continuous intervention,the clinical efficacy,recovery of related symptoms and adverse reactions of BA children were evaluated.The changes in lung function parameters,inflammation indicators and quality of life were compared before and after treatment in the IRRT group and the conventional group,and the changes in lung function parameters,inflammation indicators and quality of life between the IRRT group and the conventional group after treatment were compared.Results A total of 120 BA children were included in the study,with 60 cases in each group.Before treatment,there was no significant difference in baseline data such as age and gender between the two groups(P>0.05).After 8 weeks of treatment,pulmonary function parameters,inflammation indicators,and quality of life were all improved in the IRRT group and the conventional group,(P<0.05),and the improvement in the IRRT group was better than that in the conventional group(P<0.05).In addition,the disappearance time of wheezing,disappearance time of cough,and disappearance time of dyspnea were significantly shorter than those in the conventional group(P<0.05).In terms of safety,no significant serious adverse effects were seen in the IRRT group and the conventional group.Conclusion Adjuvant IRRT therapy can significantly improve children's lung function,reduce the level of inflammatory factors,shorten the course of the disease,improve quality of life,and promote early recovery in children.

Objective:To explore the value of the classifier model based on CT radiomic characteristics in predicting the activity of pulmonary cystic echinococcosis (CE).Methods:The study was designed as cross-sectional. A retrospective analysis was performed on 81 patients diagnosed with pulmonary CE in the First Affiliated Hospital of Xinjiang Medical University from January 2010 to October 2020. The Python function divided 17 cases into an internal verification group and 64 cases into a training group with a ratio of 2∶8. In addition, 16 patients diagnosed with pulmonary CE from the Fourth Affiliated Hospital of Xinjiang Medical University from October 2020 to 2024 were included in the external validation group. All patients underwent CT examination, and radiomics features were extracted using Radcloud platform of Huimedi Huiying. The intraclass correlation coefficient was performed on the features, then feature screening was performed using the SelectKBest method, variance thresholding method, and least absolute shrinkage and selection operator. Finally, three classifiers (including support vector machine (SVM), K-neighborhood (KNN), and logistic regression (LR)) were used to build the models. The receiver operating characteristic curve and area under the curve (AUC) were used to evaluate the model′s efficiency.Results:Among 81 patients with lung CE, 58 were male, and 23 were female. twenty-eight lesions were active and 53 were inactive. A total of 11 optimal features were selected. Based on the selected features, the SVM classifier model, KNN classifier model, and LR classifier model were established. The KNN classifier model in the training group had the highest AUC value (0.93) and the highest specificity (0.98) in predicting lung CE activity. In the internal validation group, the SVM classifier model had the highest AUC value (0.92) and the highest specificity (0.91) in predicting lung CE activity. The LR classifier model performed best with the highest AUC of 0.85 for predicting lung CE activity in the external validation group, and the specificity of the three models was 0.92.Conclusion:The classifier model established based on CT radiomic features has a certain value in predicting lung CE activity, and may be helpful in clinical decision-making.

Objective:To explore the occurrence and influencing factors of perimenopausal syndrome among Han, Hui and Tibetan women in Gansu Province.Methods:A stratified cluster sampling method was used to select 7290 women aged 40-55 years as the research subjects for cross-sectional survey. The questionnaire was used to investigate demographic characteristics, marriage and childbearing menstrual history, and the modified Kupperman score was used to investigate the symptoms related to perimenopausal syndrome. The data were statistically analyzed using SPSS20.0 software.Results:The natural menopausal age of women in Gansu Province was (47.43±3.99) years old, Hui women had the earliest age of menopause (47.08±4.29). There were statistically significant differences in occupation, education level and residence among the three ethnic groups ( P<0.001, P=0.001, P=0.005). The incidence of perimenopausal syndrome was 58.85% (246/418) for Hui, 44.16% (136/308) for Tibetans, and 41.06% (2695/6564) for Hans. The incidence of perimenopausal syndrome and the grade of related symptoms were significantly different among the three ethnic groups (all P<0.001). Han women had the highest proportion of mild symptoms, while Hui women and Tibetan women had the highest proportion of moderate symptoms. The differences of the incidence of mild and severe symptoms among the three ethnic groups were statistically significant (all P<0.001). Logistic regression analysis showed that engaging in heavy physical labor is a common risk factor for the incidence of perimenopausal syndrome in the three ethnic groups. Conclusion:The prevention and treatment of perimenopausal syndrome can be carried out from the following aspects: promoting economic development, improving living conditions, changing life and work patterns, increasing investment in education, medical and health care, and strengthening knowledge popularization.

Objective:To explore the occurrence and influencing factors of perimenopausal syndrome among Han, Hui and Tibetan women in Gansu Province.Methods:A stratified cluster sampling method was used to select 7290 women aged 40-55 years as the research subjects for cross-sectional survey. The questionnaire was used to investigate demographic characteristics, marriage and childbearing menstrual history, and the modified Kupperman score was used to investigate the symptoms related to perimenopausal syndrome. The data were statistically analyzed using SPSS20.0 software.Results:The natural menopausal age of women in Gansu Province was (47.43±3.99) years old, Hui women had the earliest age of menopause (47.08±4.29). There were statistically significant differences in occupation, education level and residence among the three ethnic groups ( P<0.001, P=0.001, P=0.005). The incidence of perimenopausal syndrome was 58.85% (246/418) for Hui, 44.16% (136/308) for Tibetans, and 41.06% (2695/6564) for Hans. The incidence of perimenopausal syndrome and the grade of related symptoms were significantly different among the three ethnic groups (all P<0.001). Han women had the highest proportion of mild symptoms, while Hui women and Tibetan women had the highest proportion of moderate symptoms. The differences of the incidence of mild and severe symptoms among the three ethnic groups were statistically significant (all P<0.001). Logistic regression analysis showed that engaging in heavy physical labor is a common risk factor for the incidence of perimenopausal syndrome in the three ethnic groups. Conclusion:The prevention and treatment of perimenopausal syndrome can be carried out from the following aspects: promoting economic development, improving living conditions, changing life and work patterns, increasing investment in education, medical and health care, and strengthening knowledge popularization.

Objective:To systematically evaluate the efficacy of Kuntai capsule in the treatment of ovarian reserve dysfunction.Methods:CNKI, CBM, Wanfang database, VIP database, PubMed, EMbase database， and clinical trail registration (https://clinicaltrials.gov/) were searched from inception to July 2019 to collect randomized controlled trials (RCTs) about Kuntai capsule in treatment of ovarian reserve dysfunction. Literatures ware screened independently by two evaluators. After information extraction and risk assessment, meta analysis was performed by Rev Man 5.3 software.Results:A total of 14 radomized controlled trials （RCTs) involving 1191 patients were included. Meta analysis showed that there were significant differences in the number of antral follicle count (MD=0.83, 95% CI=0.32-1.35, P=0.001) between Kuntai capsule group and control group. There was no significant difference in serum anti-Müllerian hormone (AMH) level (MD=0.11, 95% CI=-0.04-0.26, P=0.14) and Kupperman score (MD=-2.67, 95% CI=-7.43-2.10, P=0.27) between the two groups. Conclusion:Kuntai capsule can effectively increase the number of antral follicle count for patients with ovarian reserve dysfunction, but there was no significant improvement in serum AMH level and it can not reduce the Kupperman score. However, due to the quantity and quality of the study, the above conclusions need to be verified by more research.

Objective:To systematically evaluate the efficacy of Kuntai capsule in the treatment of ovarian reserve dysfunction.Methods:CNKI, CBM, Wanfang database, VIP database, PubMed, EMbase database， and clinical trail registration (https://clinicaltrials.gov/) were searched from inception to July 2019 to collect randomized controlled trials (RCTs) about Kuntai capsule in treatment of ovarian reserve dysfunction. Literatures ware screened independently by two evaluators. After information extraction and risk assessment, meta analysis was performed by Rev Man 5.3 software.Results:A total of 14 radomized controlled trials （RCTs) involving 1191 patients were included. Meta analysis showed that there were significant differences in the number of antral follicle count (MD=0.83, 95% CI=0.32-1.35, P=0.001) between Kuntai capsule group and control group. There was no significant difference in serum anti-Müllerian hormone (AMH) level (MD=0.11, 95% CI=-0.04-0.26, P=0.14) and Kupperman score (MD=-2.67, 95% CI=-7.43-2.10, P=0.27) between the two groups. Conclusion:Kuntai capsule can effectively increase the number of antral follicle count for patients with ovarian reserve dysfunction, but there was no significant improvement in serum AMH level and it can not reduce the Kupperman score. However, due to the quantity and quality of the study, the above conclusions need to be verified by more research.

Objective To investigate the predictive value of ultrasonic tissue charateristics of carotid atherosclerotic plaques in cardiocerebrovascular events in patients with type 2 diabetes mellitus (T2DM).Methods From January 2003 to December 2015,patients with T2DM treated in Xi'an Gaoxin Hospital were selected.Their carotid atherosclerotic plaques were examined by ultrasound.Intergrated backscatter (IBS) and thickness of carotid plaques of the patients were documented.The cardiocerebrovascular events were folbwed up prospectively.Kaplan-Meier curve,COX proportional risk regression model,and receiver operating characteristic (ROC) curve were used to compare and analyze the predictive values of calibratedIBS (C-IBS),Framingham Risk Score (FRS) and plaque thickness for the risk of cardiocerebrovascular events in patients with T2DM.Results There was significant difference in the risk of cardiovascular events between the low C-IBS group (n=48,C-IBS ＜17.1 dB) and the high C-IBS group (n=48,C-IBS ≥17.1 dB) (35.4％ vs.12.5％;P=0.015).There was no significant difference in the risk of cardiocerebrovascular events between the thin plaque group (n =48,plaque thickness ＜ 1.3 mm) and the thick plaque group (n=48,plaque thickness ＞1.3 mm) (14.6％ vs.33.3％;P=0.070).COX proportional risk regression model analysis showed that C-IBS (hazard ratio,1.505,95％ confidence interval 1.196-1.893,P=0.001) and plaque thickness (hazard ratio,4.794,95％ confidence interval 1.142-20.130,P =0.032) were the independent risk factors for the risk of cardiocerebrovascular events.ROC curve analysis found that the combination of C-IBS,FRS and plaque thickness could predict the risk of cardiocerebrovascular events in patients with T2DM.Conclusion Ultrasonic tissue characteristics of carotid atherosclerotic plaque (C-IBS and plaque thickness) in combination with FRS may predict cardiocerebrovascular events in patients with T2DM.

Objective To explore the effects of multidisciplinary comprehensive pulmonary rehabilitation on aged patients with pneumo-coniosis. Methods From January, 2012 to January, 2015, 85 old stable inpatients with pneumoconiosis were divided into control group (n=40) and rehabilitation group (n=45). Both groups accepted routine medicine, while the rehabilitation group received multidisciplinary com-prehensive pulmonary rehabilitation for twelve weeks. They were assessed with cardiopulmonary exercise test, BODE index and quality of life before and after treatment. Results The maximum work, maximal oxygen uptake, 6-minute walk distance, scores of modified Version of the British Medical Researsh Council Respiratory Questionnaire, BODE index, activities of daily living, social activities, depression and anx-iety improved in the rehabilitation group after treatment (t>3.379, P<0.01), and were better than those in the control group (t>2.201, P<0.05). No imporvement was found in all the indices in the control group after treatment (t<2.339, P>0.05). Conclusion Multidisciplinary comprehensive pulmonary rehabilitation can effectively improve exercise tolerance and quality of life in aged patients with pneumoconiosis.