With the postponement of human reproductive time, studying how to intervene in reproductive system aging has become a globally significant topic. Sirtuins are NAD +-dependent histone deacetylases that play key roles in gene regulation, apoptosis, energy metabolism, age-related diseases, and the reproductive system. Current evidence suggests that deletion of the Sirtuins gene leads to developmental disorders and reproductive aging in both males and females, and that pharmacological intervention in Sirtuins expression can affect aging-induced decline in reproductive function. This review provides a comprehensive review of the effects and mechanisms of Sirtuins on male and female reproductive aging, and lists some natural drugs that can modulate Sirtuins activity, providing ideas for further studies on the regulation of reproductive aging at the molecular level.

With the postponement of human reproductive time, studying how to intervene in reproductive system aging has become a globally significant topic. Sirtuins are NAD +-dependent histone deacetylases that play key roles in gene regulation, apoptosis, energy metabolism, age-related diseases, and the reproductive system. Current evidence suggests that deletion of the Sirtuins gene leads to developmental disorders and reproductive aging in both males and females, and that pharmacological intervention in Sirtuins expression can affect aging-induced decline in reproductive function. This review provides a comprehensive review of the effects and mechanisms of Sirtuins on male and female reproductive aging, and lists some natural drugs that can modulate Sirtuins activity, providing ideas for further studies on the regulation of reproductive aging at the molecular level.

Aging is a process of degenerative change that occurs as a result of time-related accumulation,associated with age-related diseases.Understanding the causes and mechanisms of aging and finding drugs that can effectively delay aging and prevent and cure age-related diseases currently present a great challenge for humans.Aging animal models thus represent an important tool in aging research,and various aging animal models have been created using different aging mechanisms.These different models having specific advantages and disadvantages,making them suitable for different research purposes.This review considers aging rodent models to provide information for aging research.