The pathogenesis of metabolic dysfunction-associated steatotic liver disease （MASLD） is fundamentally rooted in spleen deficiency and is closely associated with phlegm turbidity， damp-heat and blood stasis. Clinically， liver constraint with spleen deficiency and internal retention of damp turbidity represent the predominant traditional Chinese medicine （TCM） syndrome patterns. Researches have indicated intrinsic connections between the syndrome patterns and biological indicators such as gut microbiota and metabolic profiles. Regarding treatment， classical famous formulas， modern empirical formulas， and newly developed TCM drugs show positive effects in regulating glucose and lipid metabolism， improving insulin resistance， and alleviating metabolic inflammation， exhibiting multi-target mechanisms of action； acupuncture and other external therapies also provide adjunctive value. Nevertheless， current researches still have limitations such as the lack of high-quality clinical evidence and insufficient systematic elucidation of the uncerlying mechanisms. Future efforts should focus on conducting high-quality TCM clinical trials with hard endpoint outcomes such as hepatic histology outcomes， and utilizing modern technologies like multi-omics to elucidate TCM's mechanisms of action， thereby advancing the position of TCM as a first-line therapeutic strategy for MASLD.

Obstructive sleep apnea (OSA) is a global public health concern characterized by repeated upper airway collapse during sleep. Research indicates that OSA is a risk factor for the development of various diseases, including cardiovascular disease, metabolic disorders, respiratory diseases, neurodegenerative diseases, and cancer. Exosomes, extracellular vesicles released by most cell types, play a key role in intercellular communication by transporting their contents-such as microRNA, messenger RNA, DNA, proteins, and lipids-to target cells. Intermittent hypoxia associated with OSA alters circulating exosomes and promotes a range of cellular structural and functional disturbances involved in the pathogenesis of OSA-related diseases. This review discusses the potential roles of exosomes and exosome-derived molecules in the onset and progression of OSA-associated diseases, explores the possible underlying mechanisms, and highlights novel strategies for developing exosome-based therapies for these conditions.
Humans ; Exosomes/physiology* ; Sleep Apnea, Obstructive/metabolism* ; Animals ; MicroRNAs/metabolism*

Triple-negative breast cancer is therapeutically challenging due to the low expression of tumor markers and 'cold' tumor immunosuppressive microenvironment. Here, we present a dual-targeting peptide-drug conjugate (PDC) for tumor inhibition. Our PDC efficiently and selectively delivers cytotoxic Monomethyl Auristatin E (MMAE) into tumor cells via C-X-C chemokine receptor type 4 (CXCR4) and folate receptor 1 (FOLR1) for synergistic inhibition of growth and metastasis. Our results show that the dual-targeting PDC has potent antitumor activity in cultured human cells and several murine transplanted tumor models without apparent toxicity. The combination of dual-targeting PDC and radiotherapy modulates the tumor immunosuppressive microenvironment by increasing CD8⁺ T cell infiltration and attenuating the proportion of myeloid-derived suppressor and regulatory T cells. Therefore, our dual-targeting PDC represents a promising new strategy for cancer therapy that rebalances the immune system and promotes tumor regression.

Single-incision laparoscopic cholecystectomy (SILC) represents a significant evolution in minimally invasive surgery, designed to accomplish cholecystectomy via a single umbilical incision. This approach seeks to reduce abdominal wall trauma while optimizing cosmetic outcomes. SILC is a safe and feasible minimally invasive technique for cholecystectomy under defined conditions; however, its broader adoption will require further evidence-based research and the establishment of standardized protocols to support its widespread implementation. When performed by skilled surgeons in carefully selected patients, SILC demonstrates clinical outcomes comparable to those of conventional multiport laparoscopic cholecystectomy, with notable improvements in incision aesthetics. Nonetheless, the technique is limited by a constrained operative field and a protracted learning curve. In response, continuous advancements in instrumentation and procedural modifications have propelled the further development and clinical integration of SILC. Drawing on current literature and clinical experience, this review delineates the technical characteristics, current clinical applications, primary benefits, and prevailing challenges associated with SILC.

Smart healthcare and digital transformation are the directions for development in the medical field.By Jilin University China-Japan Friendship Hospital Practice as an example,it explores the application of"artificial intelligence+big data"in the refined management service process of hospitals,focusing on its potential advantages in improving the level of medical services and meeting patient needs.By delving into the overall architecture of smart healthcare path design and refined smart management service processes,it aims to provide innovative ideas and effective methods for the digital transformation of the medical industry.

Smart healthcare and digital transformation are the directions for development in the medical field.By Jilin University China-Japan Friendship Hospital Practice as an example,it explores the application of"artificial intelligence+big data"in the refined management service process of hospitals,focusing on its potential advantages in improving the level of medical services and meeting patient needs.By delving into the overall architecture of smart healthcare path design and refined smart management service processes,it aims to provide innovative ideas and effective methods for the digital transformation of the medical industry.

Smart healthcare and digital transformation are the directions for development in the medical field.By Jilin University China-Japan Friendship Hospital Practice as an example,it explores the application of"artificial intelligence+big data"in the refined management service process of hospitals,focusing on its potential advantages in improving the level of medical services and meeting patient needs.By delving into the overall architecture of smart healthcare path design and refined smart management service processes,it aims to provide innovative ideas and effective methods for the digital transformation of the medical industry.

Smart healthcare and digital transformation are the directions for development in the medical field.By Jilin University China-Japan Friendship Hospital Practice as an example,it explores the application of"artificial intelligence+big data"in the refined management service process of hospitals,focusing on its potential advantages in improving the level of medical services and meeting patient needs.By delving into the overall architecture of smart healthcare path design and refined smart management service processes,it aims to provide innovative ideas and effective methods for the digital transformation of the medical industry.

Smart healthcare and digital transformation are the directions for development in the medical field.By Jilin University China-Japan Friendship Hospital Practice as an example,it explores the application of"artificial intelligence+big data"in the refined management service process of hospitals,focusing on its potential advantages in improving the level of medical services and meeting patient needs.By delving into the overall architecture of smart healthcare path design and refined smart management service processes,it aims to provide innovative ideas and effective methods for the digital transformation of the medical industry.

Smart healthcare and digital transformation are the directions for development in the medical field.By Jilin University China-Japan Friendship Hospital Practice as an example,it explores the application of"artificial intelligence+big data"in the refined management service process of hospitals,focusing on its potential advantages in improving the level of medical services and meeting patient needs.By delving into the overall architecture of smart healthcare path design and refined smart management service processes,it aims to provide innovative ideas and effective methods for the digital transformation of the medical industry.