Objective To analyze the epidemiological characteristics of newly diagnosed occupational coal workers' pneumoconiosis (CWP) in Gansu Province. Methods All newly diagnosed cases of CWP reported online in Gansu Province from 2005 to 2024 were collected as study subjects through the "Occupational Diseases and Health Hazard Factors Monitoring Information System". A descriptive epidemiological method was used to analyze the epidemiological characteristics. A total of 886 newly diagnosed CWP cases were reported in Gansu Province during 2005-2024. Results Among them, cases initially diagnosed as stageⅠ, stage Ⅱ, and stage Ⅲ accounted for 68.8%, 20.0%, and 11.2%, respectively. The cases were predominantly male, accounting for 99.0%. Age groups of 50-<60 years and ≥60 years accounted for 47.0% and 42.9%, respectively. In terms of regional distribution, Lanzhou City, Pingliang City, and Baiyin City were the main affected areas, accounting for 36.0%, 19.1%, and 16.4%, respectively. Regarding industry distribution, the coal mining and washing industry accounted for 91.3% of the cases. Enterprises of large and small sizes accounted for 46.0% and 29.7%, respectively. In terms of enterprise economic types, state-owned enterprises and private enterprises accounted for 54.2% and 21.6%, respectively. The median duration of dust exposure among newly diagnosed CWP cases was 18 years. As of 2024, 102 cases had progressed to a more advanced stage; among the progressed cases, stageⅠ, stage Ⅱ, and stage Ⅲ cases accounted for 58.1%, 28.3%, and 13.6%, respectively. Conclusion Cases of CWP in Gansu Province are mainly distributed in large state-owned coal mines in cities such as Lanzhou, Pingliang, and Baiyin, predominantly affecting older males with longer dust exposure durations. Therefore, occupational health supervision and management in coal dust-related enterprises in the province should be further strengthened, and the occupational health examination procedures for workers exposed to dust should be standardized.

Objective:To investigate the level of occupational health literacy (OHL) of key populations in Gansu Province in 2022, analyze the influencing factors, and provide a scientific basis for the formulation of health education measures for occupational populations.Methods:From April to December 2022, a stratified cluster random sampling method was adopted to select 11472 workers engaged in frontline jobs in 8 key industries across 86 counties and districts in Gansu Province as the research subjects. The "National Occupational Health Literacy Monitoring and Survey Personal Questionnaire" was used to investigate their OHL. The content includes basic demographic information and occupational health literacy level, and the chi-square test analysis was carried out by SPSS 23.0 software, and the influencing factors were analyzed by logistic regression analysis model.Results:In 2022, a total of 11 118 valid questionnaires were completed in Gansu Province, and the OHL level of key populations in Gansu Province was 48.3%. The OHL levels of occupational health legal knowledge, basic knowledge of occupational health protection, basic skills of occupational health protection and healthy working methods were 50.3%, 81.7%, 33.1% and 63.3%, respectively. In the eight key industries, the OHL level of workers from high to low is: ferrous and non-ferrous metal smelting and rolling processing industry (56.6%) , non-metallic mineral products industry (56.5%) , ferrous and non-ferrous metal mining and dressing industry (54.3%) , environmental sanitation industry (50.3%) , medical and health industry (49.9%) , education industry (40.9%) , transportation industry (40.4%) , and express delivery/takeaway delivery industry (23.3%) . The results of logistics regression analysis showed that gender, age, ethnicity, marital status, education level, average monthly income, nature and scale of employers, and length of service were the influencing factors of OHL level of front-line workers in eight industries in Gansu Province (all P<0.05) . Conclusion:In 2022, the OHL level of key populations in Gansu Province was 48.3%, which needs to be further improved. Occupational health publicity should be strengthened for low-income, low-educated, newly recruited, young and micro-enterprise occupational groups.

Objective:To investigate the level of occupational health literacy (OHL) of key populations in Gansu Province in 2022, analyze the influencing factors, and provide a scientific basis for the formulation of health education measures for occupational populations.Methods:From April to December 2022, a stratified cluster random sampling method was adopted to select 11472 workers engaged in frontline jobs in 8 key industries across 86 counties and districts in Gansu Province as the research subjects. The "National Occupational Health Literacy Monitoring and Survey Personal Questionnaire" was used to investigate their OHL. The content includes basic demographic information and occupational health literacy level, and the chi-square test analysis was carried out by SPSS 23.0 software, and the influencing factors were analyzed by logistic regression analysis model.Results:In 2022, a total of 11 118 valid questionnaires were completed in Gansu Province, and the OHL level of key populations in Gansu Province was 48.3%. The OHL levels of occupational health legal knowledge, basic knowledge of occupational health protection, basic skills of occupational health protection and healthy working methods were 50.3%, 81.7%, 33.1% and 63.3%, respectively. In the eight key industries, the OHL level of workers from high to low is: ferrous and non-ferrous metal smelting and rolling processing industry (56.6%) , non-metallic mineral products industry (56.5%) , ferrous and non-ferrous metal mining and dressing industry (54.3%) , environmental sanitation industry (50.3%) , medical and health industry (49.9%) , education industry (40.9%) , transportation industry (40.4%) , and express delivery/takeaway delivery industry (23.3%) . The results of logistics regression analysis showed that gender, age, ethnicity, marital status, education level, average monthly income, nature and scale of employers, and length of service were the influencing factors of OHL level of front-line workers in eight industries in Gansu Province (all P<0.05) . Conclusion:In 2022, the OHL level of key populations in Gansu Province was 48.3%, which needs to be further improved. Occupational health publicity should be strengthened for low-income, low-educated, newly recruited, young and micro-enterprise occupational groups.

Objective To investigate the association between occupational stress and activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patients with metabolic syndrome.Methods A case-control study was performed.According to inclusion and exclusion criteria,among the staff members of enterprises and public institutions aged 20～60 years who underwent physical examination in The Affiliated Hospital of Ningxia Medical University and The People's Hospital of Wuzhong from October 2011 to October 2012,622 patients with metabolic syndrome who did not have a blood relationship with each other were enrolled as case group,and 600 healthy staff members who also did not have a blood relationshipwith each otherwere enrolled as control group.Questionnaire investigation,chronic occupational stress investigation,physical examination,and laboratory tests were performed for all subjects.Results Compared with the control group,the case group had significantly higher serum levels and abnormal rates of AST and ALT (t=-4.338 and-5.485,x2=11.168 and 34.302,all P＜0.05).There were no significantdifferences in the serum level and abnormal rate of AST between the subgroups with different occupational stresses in both groups (F=2.192 and 2.567,x2=2.694 and 5.402,all P＞0.05),but there were significant differencesbetween the subgroups in all subjects (F=5.005,x2=6.398,all P＜0.05).There were no significant differences in the serum level and abnormal rate of ALT between thesubgroups with different occupational stresses in the case group,the control group,and all subjects (F=0.845,0.450,and 1.416,x2=2.564,1.344,and 3.147,all P＞0.05).The partial correlation analysis showed that the total score of occupational stress was positively correlated withthe serum level of AST (r=0.071,P＜0.05) and was not correlatcd with the serum level of ALT(r=-0.044,P＞0.05),and that the serum level of AST was positively correlated with that of ALT (r=0.736,P＜0.05).After the adjustment for age,sex,nationality,smoking,drinking,marital status,and degree of education,the total score of occupational stress was positively correlated with the serum level of AST (r=0.069,P＜0.05) and was not correlated with the serum level of ALT (r=-0.042,P＞0.05),and the serum level of AST was positively correlated with that of ALT(r=0.730,P＜0.05).The multiple linear regression analysis showed that the serum level of AST increased with the increasing occupational stress (b=0.131,P=0.013).Conclusion Occupational stress is associated with increased serum level of AST,and the serum level of AST increases with the increasing occupational stress.Increased risk of metabolic syndrome caused by occupational stress may be associated with the increased activity of AST caused by occupational stress.

Objective To investigate the association between occupational stress and activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patients with metabolic syndrome.Methods A case-control study was performed.According to inclusion and exclusion criteria,among the staff members of enterprises and public institutions aged 20～60 years who underwent physical examination in The Affiliated Hospital of Ningxia Medical University and The People's Hospital of Wuzhong from October 2011 to October 2012,622 patients with metabolic syndrome who did not have a blood relationship with each other were enrolled as case group,and 600 healthy staff members who also did not have a blood relationshipwith each otherwere enrolled as control group.Questionnaire investigation,chronic occupational stress investigation,physical examination,and laboratory tests were performed for all subjects.Results Compared with the control group,the case group had significantly higher serum levels and abnormal rates of AST and ALT (t=-4.338 and-5.485,x2=11.168 and 34.302,all P＜0.05).There were no significantdifferences in the serum level and abnormal rate of AST between the subgroups with different occupational stresses in both groups (F=2.192 and 2.567,x2=2.694 and 5.402,all P＞0.05),but there were significant differencesbetween the subgroups in all subjects (F=5.005,x2=6.398,all P＜0.05).There were no significant differences in the serum level and abnormal rate of ALT between thesubgroups with different occupational stresses in the case group,the control group,and all subjects (F=0.845,0.450,and 1.416,x2=2.564,1.344,and 3.147,all P＞0.05).The partial correlation analysis showed that the total score of occupational stress was positively correlated withthe serum level of AST (r=0.071,P＜0.05) and was not correlatcd with the serum level of ALT(r=-0.044,P＞0.05),and that the serum level of AST was positively correlated with that of ALT (r=0.736,P＜0.05).After the adjustment for age,sex,nationality,smoking,drinking,marital status,and degree of education,the total score of occupational stress was positively correlated with the serum level of AST (r=0.069,P＜0.05) and was not correlated with the serum level of ALT (r=-0.042,P＞0.05),and the serum level of AST was positively correlated with that of ALT(r=0.730,P＜0.05).The multiple linear regression analysis showed that the serum level of AST increased with the increasing occupational stress (b=0.131,P=0.013).Conclusion Occupational stress is associated with increased serum level of AST,and the serum level of AST increases with the increasing occupational stress.Increased risk of metabolic syndrome caused by occupational stress may be associated with the increased activity of AST caused by occupational stress.

BACKGROUND:At present,new drug and dosage form to treat diabetes mellitus has emerged continually,but it has toxic reaction,side effects,and contraindication or unindication.Especially that it cannot prevent the natural proceeding of diabetes mellitus from aggravation.Based on theory and experience of traditional Chinese medicine,and combining modern methods of pharmacology and pharmaceutical chemistry,it has become one of the hotspots in researches on diabetes mellitus at present to investigate and empolder preparation of pure traditional Chinese medicine that has good effect and little toxicity.OBJECTIVE:To investigate the pharmacological effect of Chinese compound of Qiangyi Jiangtang capsules on diabetic rat models induced by high-fat forage and streptozotocin.DESIGN:A comparative observation of animal trial.SETTING:Staff Room of Pharmacology,Yunnan College of Traditional Chinese Medicine.MATERIALS:Totally 100 2-month-old Wistar rats of common degree,weighing(180±25)g were used.There were 50 males and 50 females,14 rats were randomly selected as the blank control group,and the other 84 rats were used in model establishment.The treatments of the animals in the experiment were accorded with the ethical standard.METHODS:The experiment was carried out in the Staff Room of Pharmacology,Yunnan College of Traditional Chinese Medicine from March to April in 2004.Diabetic models were induced by high-fat forage and streptozotocin.The successful model rats (n=54) were randomly divided into the model group,positive control group and the high,middle and low dosage of Qiangyi Jiangtang capsules groups.The dosages in the low,middle and high dosages treated groups were 0.4,1.2 and 2.0 g/kg respectively. The rats in the blank control group and model group were given isovolume of saline,and those in the positive control group were administrated intragastrically with metformin (0.5 g/kg).After administration,blood glucose,glycosylated hemoglobin and serum fructosamine were determined at 1 month,and the amounts of water drinking and food intake were determined at the 2nd and 4th weeks.MAIN OUTCOME MEASURES:Results of blood glucose,glycosylated hemoglobin and serum fructosamine;amounts of water drinking and food intake.RESULTS:Totally 100 Wistar rats were used,32 of them were excluded due to failure in the model establishment,and the other 68 were involved in the final analysis of results.The blood glucose,glycosylated hemoglobin and serum fructosamine in the high,middle and low dosages of Qiangyi Jiangtang capsules groups were all significantly lower than those in the model group(P＜0.01).The amounts of water drinking at the 2nd and 4th weeks in the high,middle and low dosages of Qiangyi Jiangtang capsules groups were significantly lower than those in the model group (P＜0.01),and the amounts of food intake were also lower than those in the model group (P＜0.05 or 0.01).CONCLUSION: Qiangyi Jiangtang capsules could remarkably decrease the levels of blood glucose, glycosylated hemoglobin and serum fructosamine,and the amounts of water drinking and food intake of rat models of diabetes mellitus.It was proved that traditional Chinese medicine for diabetes mellitus is worthy of further development and research.