Lung cancer is the most common ma-lignant tumors in clinical practice,posing a signifi-cant threat to human health.In recent years,with the advancement of high-throughput sequencing technologies,a large number of non-coding RNAs(ncRNAs)have been found to play crucial roles in the regulation of apoptosis in lung cancer cells.This article reviews the research progress of ncRNA(miRNA,lncRNA,circRNA,piRNA)mediated apopto-sis in lung cancer,aiming to provide new theoreti-cal basis for ncRNA therapy of lung cancer.

Lung cancer is the most common ma-lignant tumors in clinical practice,posing a signifi-cant threat to human health.In recent years,with the advancement of high-throughput sequencing technologies,a large number of non-coding RNAs(ncRNAs)have been found to play crucial roles in the regulation of apoptosis in lung cancer cells.This article reviews the research progress of ncRNA(miRNA,lncRNA,circRNA,piRNA)mediated apopto-sis in lung cancer,aiming to provide new theoreti-cal basis for ncRNA therapy of lung cancer.

Objective To investigate the association between CHI3L1 polymorphism and asthma in the Han population of Guangdong,and to explore the clinical values of chitinase-like protein YKL-40 in evaluating disease severity and monitoring the progression of the disease.Methods Total 251 objects were divided into asthma group (n=150)and control group(n=101).The single nucleotide polymorphism (SNP)at CHI3L1 gene was detected with Massarray method. The serum YKL-40 levels, total IgE levels, peripheral blood eosinophil percentage (Eos%)of the obj ects in asthma and control groups were detected. The asthma patients were divied into asthma exacergation group and stable group,and the serum YKL-40 levels were compared.Results The distribution of A/G at rs3806448 of CHI3L1 had significant difference between asthma and control groups (P<0.01 ), and the frequency of A allele at rs3806448 of the patients in asthma group was significantly higher than that in control group (OR= 1.93,95% CI=1.30-2.62,χ2=11.6,P<0.01).The serum YKL-40 levels,total IgE and Eos% of the patients with AA at rs3806448 were higher than those of the patients with GG or AG at rs3806448 (P<0.05);the FEV1% of the patients with AA was lower than those of the patients with GG or AG at rs3806448(P<0.01). The serum YKL-40 level of the patients in asthma group was significantly higher than that in normal control group (P<0.01),and the serum YKL-40 level of the patients in asthma exacergation group was higher than those in asthma stable group and normal control group(P<0.01).The serum YKL-40 level of the patients in asthma group was positively correlated with the peripheral blood Eos% and total IgE level(rEos=0.348,rIgE=0.437,P<0.01), and was negatively correlated with the lung function(r=-0.745,P<0.01). Conclusion The polymorphism of CHI3L1-rs3806448 may correlate with asthma of Han population in Guangdong area.The serum YKL-40 may be a new biomarker to evaluate asthma disease severity and helpful for monitoring illness stage.