Objective To explore the intervention effect of remote hypertension health management mode with"Dayi Jiankangxing"as the core on hypertension patients.Methods Patients with primary hypertension who were treated in the First Affiliated Hospital of Baotou Medical College from January 2023 to January 2024 were divided into control group and intervention group by random number table method,with 101 cases in each group.The patients in control group were managed with traditional hypertension management,while the patients in intervention group were managed with a remote hypertension mode centered on"Dayi Jiankangxing".After 6 months of management,the blood pressure compliance rate,quality of life and medication compliance of two groups were compared.Results After 6 months,the blood pressure compliance rate of intervention group was significantly higher than that of control group(60.4％vs.40.6％,x2=7.922,P=0.005).The medication compliance of patients in intervention group was significantly higher than that in control group(x2=7.371,P=0.025).The scores of physiological function,general health status,energy,social function,emotional function and mental health of patients in intervention group were significantly higher than those in control group(P＜0.05).Conclusion The remote hypertension health management mode with"Dayi Jiankangxing"as the core is helpful for hypertension patients to control blood pressure,improve medication compliance and improve quality of life.

Objective To explore the intervention effect of remote hypertension health management mode with"Dayi Jiankangxing"as the core on hypertension patients.Methods Patients with primary hypertension who were treated in the First Affiliated Hospital of Baotou Medical College from January 2023 to January 2024 were divided into control group and intervention group by random number table method,with 101 cases in each group.The patients in control group were managed with traditional hypertension management,while the patients in intervention group were managed with a remote hypertension mode centered on"Dayi Jiankangxing".After 6 months of management,the blood pressure compliance rate,quality of life and medication compliance of two groups were compared.Results After 6 months,the blood pressure compliance rate of intervention group was significantly higher than that of control group(60.4％vs.40.6％,x2=7.922,P=0.005).The medication compliance of patients in intervention group was significantly higher than that in control group(x2=7.371,P=0.025).The scores of physiological function,general health status,energy,social function,emotional function and mental health of patients in intervention group were significantly higher than those in control group(P＜0.05).Conclusion The remote hypertension health management mode with"Dayi Jiankangxing"as the core is helpful for hypertension patients to control blood pressure,improve medication compliance and improve quality of life.

Objective To study the effect of nano-ceria on doxorubicin-induced cardiotoxic injury and its effect on P53 gene expression,and to explore the mechanism of nano-ceria on doxorubicin-induced cardiotoxic injury.Methods H9C2 myocardial cells were cultured and randomly divided into five groups:control group,model group(1μmol/L adriamycin),nano-cerium oxide group(10μg/ml nano-cerium oxide),experimental group(1μmol/L adriamycin +10μg/ml nano-cerium oxide),and positive control group(1μmol/L adriamycin+10μmol/L dexperimine).The adriamycin induced cardiotoxicity model was established,and the viability of myocardial cells was measured by CCK-8 method.The contents of lactate dehydrogenase(LDH)and malondialdehyde(MDA)in myocardial cells were detected by biochemical method.The levels of reactive oxygen(ROS)and the apoptosis rate in myocardial cells were detected by flow cytometry.The expressions of Bax,Bcl-2 and P53 proteins in myocardial cells were detected by Western blot.Results Compared with the control group,the cell viability was decreased in the model group,the cell LDH and MDA contents were increased,the intracellular ROS level and apoptosis rate were increased,the expressions of Bax and P53 proteins were increased,and the expression of Bcl-2 protein was decreased,and the ratio of Bcl-2/Bax was decreased(all P<0.001).Compared with the model group,the experimental group showed increased cell viability,decreased cell LDH and MDA contents,decreased cell ROS content and apoptosis rate,decreased Bax and P53 protein expressions,and increased Bcl-2 protein expression,and the Bcl-2/Bax ratio was increased(all P<0.001).Conclusion Ceria nanoparticles can effectively prevent adriamycin-induced cardiotoxic injury,and its effect may be related to the down-regulation of P53 gene to inhibit cardiomyocyte apoptosis.

Dose-dependent cardiotoxicity of anthracyclines limits its further use in cancer therapy. Recent animal studies have shown that cerium oxide nanoparticles in conjunction with anthracyclines can improve the efficacy of chemotherapy without increasing the damage to normal heart cells. This article introduces the biomedical properties of cerium oxide nanoparticles and the related mechanisms of cardiotoxicity of anthracyclines, and reviews the anti-oxidative stress and anti-apoptosis effects of cerium oxide nanoparticles in the cardiotoxicity of anthracyclines, so as to provide a possible strategy for clinical prevention and treatment of anthracyclines cardiotoxicity.

OBJECTIVETo investigate the possible effects of long-term exposure to dust containing thorium and thoron progeny on dust-exposed miners.

METHODSA negative, high voltage, exhaled thoron progeny measurement system was used to estimate the miners' thorium lung burden.

RESULTSThe highest thorium lung burden of 638 miners was 11.11 Bq. The incidence of stage 0(+) pneumoconiosis was higher among dust-exposed miners. Lung cancer mortality of the dust-exposed miners was significantly higher than that of controls (P < 0.005).

CONCLUSIONThere is a difference in cancer rates between those who have long-term exposure to dust containing thorium (in which carcinogenic ThO(2) and SiO(2) exist) and thoron progeny and those who have not.

Air Pollutants, Radioactive ; adverse effects ; Body Burden ; China ; epidemiology ; Dust ; Follow-Up Studies ; Humans ; Lung Neoplasms ; epidemiology ; Mining ; Occupational Diseases ; epidemiology ; Occupational Exposure ; adverse effects ; Thorium ; adverse effects