Objective: To determine the internal relationships pf perceived discrimination and rejection sensitivity with social adjustment among college students with left behind experiences, so as to provide a reference for targeted prevention and intervention strategies for social adjustment issues in this population. Methods: A cluster random sampling method was used to select 2 999 college students from 3 universities in Qiqihar and Daqing, Heilongjiang Province. In October, 2024 (T1) and April 2025 (T2), the Discrimination Perception Questionnaire of college students, Rejection Sensitivity Questionnaire, and the Chinese College Student Adjustment Scale (CCSAS) were used to assess students perceptions of discrimination, rejection sensitivity, and social adjustment levels. Independent sample t-test was used for group comparisons. Traditional cross sectional comparisons and cross sectional network analysis were performed using T1 data for the core sample of 1 080 students with left behind experiences (T1). Longitudinal network analysis was performed using paired data from T1 and T2 ( n =1 024) and a preliminary cross lagged model was used to determine the relationships between variables. Sensitivity analysis was performed by including followup data from students without left behind experiences to test the robustness of the results. Results: After gender adjustment, students with leftbehind experiences had higher scores on discrimination perception (13.14±0.16) and rejection sensitivity (92.82±0.73) compared to the non left behind group (10.25±0.12) (89.12±0.55) while the social adjustment score (194.94±1.05) was lower than the non left behind group (202.82±0.79). The differences were statistically significant ( F =212.03, 16.52, 36.02, all P <0.01). Cross sectional network analysis showed that the "anticipated rejection likelihood" was the core node ( EI=-2.27 , BEI =-2.37), playing a key role in inter network connections and overall dynamic regulation. Longitudinal network comparison revealed statistically significant changes in the intensity centrality of the nodes "individual discrimination perception" and "anticipated rejection likelihood" (both P <0.05), while other nodes remained relatively stable. Cross lagged network analysis showed that the predictive effects of T1 on the variables at T2 were not statistically significant (maximum | r |=0.05, FDR corrected P >0.50), but the binomial test indicated a systematic positive correlation trend between the variables (66.7% positive correlation, P =0.04). Sensitivity analysis showed that the bridge effect of the "anticipated rejection likelihood" and "learning adjustment" nodes at T2 was more significant in the left behind group compared to the non left behind group. Conclusion The social adjustment issues of college students with left behind experiences require focused attention on the negative regulatory effect of "rejection cognition" and the positive regulatory effect of "learning adaptation".

In the special periods of puberty,menstruation,pregnancy,postpartum,and perimenopause of the female life,the drastic changes in qi and blood of the women cause the redistribution of qi,blood,yin and yang in those periods,which easily leads to various disordered states of disharmony between nutrient qi and defensive qi,disharmony between qi and blood,and imbalance of yin and yang.By analyzing the mechanism of the disharmony between nutrient qi and defensive qi in the special periods of puberty,menstruation,pregnancy,postpartum,and perimenopause of the female life,this paper proposes the approach of harmonizing nutrient qi and defensive qi to treat menstrual disorders,leukorrheal disease,gravid trouble,and parturition problems.Moreover,It is recommended that Guizhi Tang(Cinnamomi Ramulus Decoction),the chief of ZHANG Zhong-Jing's prescriptions and having the actions of releasing muscles and harmonizing nutrient qi and defensive qi,and activiting qi and harmonizing yin and yang,can be used to treat gynecological diseases through the modification.The utilization of Guizhi Tang for the treatment of gynecological diseases at various periods of women's lives will expand the application of classical prescriptions in treating gynecological diseases.

Objective Discuss the safety and effectiveness of flow diverter device and traditional stent inthetreatment of unruptured ophthalmic segment aneurysms.Methods A retrospective analysis from January 2017 to January 2023 was performed on the clinical data of 70 cases of unruptured aneurysms in the Department of Neurosurgery of Southern Theater General Hospital treated with stent-assisted embolization.According to the type of implanted stents,theywere divided into flow diverter device group(n = 21)and traditional stent group(n = 49),and the postoperative clinical effects and complications of the two groups were compared.Results The two groups of patients followed 3 to 24 months,with an average of(14.4±1.82)months.The results of periopera-tive and follow-up showed that the inclusion rate was higher in the flow diverter device group and the traditional stent group(93.3%vs.87.9%),with no significant difference(P>0.05),and the incidence of perioperative and short-term complications was lower(0 vs.6.1%)in the flow diverter device group than in the traditional stent group,and there currencies rate in the flow diverter device group was lower than that in the traditional stent group(0 vs.6.1%),but the difference was not significant(P>0.05).Conclusion Flow diverter devices and traditional stents in the treatment of unruptured ophthalmic segment aneurysmsare feasible,safe and effective.Preliminary results suggest that the incidence of short-term complications and retreatment is lower after treatment with flow diverter devices,and the operation time is short,but further studies are needed to validate long-term complica-tions in patients.

To investigate the effects of cigarette smoking in different manners on acute lung injury in rats.The commercially available cigarettes with tar of 1,5, 11 mg were smoked in Canada depth smoking (health canada method, HCM) manner, and those with tar of 11 mg were also smoked in international standard (ISO) smoking manner. Rats were fixed and exposed to mainstream in a manner of nose-mouth exposure. After 28 days, the bronchoalveolar lavage fluids from left lung were collected for counting and classification of inflammatory cells and determination of pro-inflammatory cytokines IL-1β and TNF-α. The right lungs were subjected to histological examination and determination of myeloperoxidase (MPO) and superoxide dismutase (SOD) activities and glutathione, reactive oxygen species (ROS) and malondialdehyde (MDA) levels.In both HCM and ISO manners, the degree of lung injury was closely related to the tar content of cigarettes, and significant decrease in the body weight of rats was observed after smoking for one week. In a HCM manner, smoking with cigarette of 11 mg tar resulted in robust infiltration of macrophages, lymphocytes and neutrophils into lungs, significant increase in IL-1β and TNF-α levels and MPO activities, and significant decrease in GSH levels and SOD activities and increase in ROS and MDA levels (all<0.05). Smoking with cigarette of 5 mg tar led to moderate increase in IL-1β and TNF-α levels, and MPO activities (all<0.05), and moderate decrease in GSH levels and SOD activities and increase of ROS and MDA levels (all<0.05). However, smoking with cigarette of 1 mg tar affected neither inflammatory cell infiltration nor IL-1β and TNF-α levels.Cigarette smoking in nose-mouth exposure manner can induce acute lung injury in rats; and the degree of lung injury is closely related to the content of tar and other hazards in cigarettes.
Acute Lung Injury ; etiology ; pathology ; physiopathology ; Animals ; Bronchoalveolar Lavage Fluid ; chemistry ; cytology ; Chemotaxis, Leukocyte ; drug effects ; Glutathione ; analysis ; drug effects ; Interleukin-1beta ; analysis ; drug effects ; Lung ; chemistry ; pathology ; Lymphocytes ; drug effects ; pathology ; Macrophages ; drug effects ; pathology ; Male ; Malondialdehyde ; analysis ; Neutrophil Infiltration ; drug effects ; Neutrophils ; drug effects ; pathology ; Peroxidase ; analysis ; drug effects ; Rats ; Reactive Oxygen Species ; analysis ; Smoking ; adverse effects ; Superoxide Dismutase ; analysis ; drug effects ; Tobacco Products ; adverse effects ; classification ; Tumor Necrosis Factor-alpha ; analysis ; drug effects ; Weight Loss ; drug effects

Biomedical Technology ; methods ; standards ; Disease Management ; Humans