Objective To study the correlations between thrombin indexes,related clinical features and prognosis of patients with spontaneous intracerebral hemorrhage.Methods Ninety-two patients with spontaneous intracerebral hemorrhage admitted to our hospital from January 2019 to January 2022 were enrolled.According to the results of modified Rankin scale(mRS)3 months after discharge,the patients were divided into good prognosis group(mRS≤2,n=65)and poor prognosis group(mRS>2,n=27).Clinical data were collected,including gender,age,body mass index(BMI),smoking,alcohol consumption,hypertension,diabetes mellitus,hyperlipidemia,National Institutes of Health Stroke Scale(NIHSS)score at admission,hematoma volume,and hematoma location.Endogenous thrombin potential(ETP),thrombin peak height(TPH)and thrombin peak time of the 2 groups were detected.Receiver operating characteristic(ROC)curve was used to analyze the value of age,NIHSS score,ETP,TPH,thrombin peak time and hematoma volume in predicting poor prognosis of patients with spontaneous intracerebral hemorrhage.Multivariate logistic regression was used to analyze the risk factors of poor prognosis in patients with spontaneous intracerebral hemorrhage.Results Age,NIHSS score,thrombin peak time,and hematoma volume in the good prognosis group were significantly lower than those in the poor prognosis group(P<0.05),while ETP,TPH and the proportion of patients with cerebellar hematoma in the good prognosis group were significantly higher than those in the poor prognosis group(P<0.05).There were no significant differences in gender composition,BMI,smoking,alcohol consumption,hypertension,diabetes mellitus,hyperlipidemia,cerebral lobe,basal ganglia or the number of brain stem hematoma between the 2 groups(P>0.05).ROC analysis proved that age,NIHSS score,ETP,TPH,thrombin peak time,and hematoma volume could predict the poor prognosis of patients with spontaneous intracerebral hemorrhage,and the areas under the curve were 0.598,0.848,0.859,0.862,0.797,and 0.852,respectively(P<0.05).Multiple logistic regression analysis confirmed that age≥59.040 years old,NIHSS score≥8.195,ETP≤420.510 nmol/(L·min),TPH≤87.395 nmol/L,thrombin peak time≥13.285 min,hematoma volume≥12.705 ml and hematoma located outside the cerebellum were risk factors for poor prognosis in patients with spontaneous intracerebral hemorrhage(P<0.05).Conclusion Age,NIHSS score,ETP,TPH,thrombin peak time,hematoma volume,and hematoma location are correlated with poor prognosis of patients with spontaneous intracerebral hemorrhage,which can provide reference for the clinical prognosis of patients with cerebral hemorrhage.