Chimeric antigen receptor T (CAR-T) cell immunotherapy is a new type of precision-targeted therapy, which can be used to modify the patient's own T cells to make them have stronger anti-tumor activity, and has achieved good results in treatment of hematologic neoplasms in recent years. Exploring the application of CAR-T cell immunotherapy in solid tumors has also been a hot research topic in recent years. The article reviews the research progress of CAR-T cell therapy for malignant tumors to provide reference for clinical application.