Objective:To investigate the effects of intraoperative administration of esketamine on gastrointestinal function in patients undergoing laparoscopic total hysterectomy.Methods:A total of 150 patients undergoing laparoscopic total hysterectomy in Dingzhou People’s Hospital from Nov. 2022 to Nov. 2023 were selected as the study subjects. They were divided into the observation group ( n=75) and the control group ( n=75) based on whether esketamine was administered intraoperatively. Patients in the control group received intravenous infusion of normal saline, while those in the observation group received intravenous infusion with added esketamine. Surgical-related time courses, drug dosages, changes in heart rate (HR) , changes in mean arterial pressure (MAP) , serum intestinal fatty acid-binding protein (I-FABP) concentrations at different time points, claudin-1 concentrations at different time points, and postoperative gastrointestinal symptom rating scale scores were observed in both groups. Results:The pneumoperitoneum duration and intraoperative drug dosage were lower in the observation group than in the control group ( P<0.01) . Statistically significant differences were found between groups, time points, and interactions for HR ( P<0.001) , with HR at T2, T3, T4, and T5 being significantly lower in the observation group than in the control group ( P<0.05) . Statistically significant differences were also found between groups, time points, and interactions for MAP changes ( P<0.001) , with MAP changes at T2, T3, T4, and T5 being significantly lower in the observation group than in the control group ( P<0.05) . Statistically significant differences were observed between groups, time points, and interactions for serum I-FABP concentrations at different time points ( P<0.001) , with the serum I-FABP concentrations at 2 hours during pneumoperitoneum and after pneumoperitoneum being significantly lower in the observation group than in the control group ( P<0.05) . Similarly, statistically significant differences were found between groups, time points, and interactions for claudin-1 concentrations at different time points ( P<0.001) , with the claudin-1 concentrations at 2 hours during pneumoperitoneum and after pneumoperitoneum being significantly lower in the observation group than in the control group ( P<0.05) . The gastrointestinal symptom score was lower in the observation group than in the control group, and the time to first flatus and first defecation was shorter in the observation group ( P<0.05) . Conclusion:The intraoperative administration of esketamine in laparoscopic total hysterectomy can promote postoperative gastrointestinal function recovery, reduce gastrointestinal symptom scores, and shorten the time to first flatus and first defecation.

Objective:To investigate the effects of intraoperative administration of esketamine on gastrointestinal function in patients undergoing laparoscopic total hysterectomy.Methods:A total of 150 patients undergoing laparoscopic total hysterectomy in Dingzhou People’s Hospital from Nov. 2022 to Nov. 2023 were selected as the study subjects. They were divided into the observation group ( n=75) and the control group ( n=75) based on whether esketamine was administered intraoperatively. Patients in the control group received intravenous infusion of normal saline, while those in the observation group received intravenous infusion with added esketamine. Surgical-related time courses, drug dosages, changes in heart rate (HR) , changes in mean arterial pressure (MAP) , serum intestinal fatty acid-binding protein (I-FABP) concentrations at different time points, claudin-1 concentrations at different time points, and postoperative gastrointestinal symptom rating scale scores were observed in both groups. Results:The pneumoperitoneum duration and intraoperative drug dosage were lower in the observation group than in the control group ( P<0.01) . Statistically significant differences were found between groups, time points, and interactions for HR ( P<0.001) , with HR at T2, T3, T4, and T5 being significantly lower in the observation group than in the control group ( P<0.05) . Statistically significant differences were also found between groups, time points, and interactions for MAP changes ( P<0.001) , with MAP changes at T2, T3, T4, and T5 being significantly lower in the observation group than in the control group ( P<0.05) . Statistically significant differences were observed between groups, time points, and interactions for serum I-FABP concentrations at different time points ( P<0.001) , with the serum I-FABP concentrations at 2 hours during pneumoperitoneum and after pneumoperitoneum being significantly lower in the observation group than in the control group ( P<0.05) . Similarly, statistically significant differences were found between groups, time points, and interactions for claudin-1 concentrations at different time points ( P<0.001) , with the claudin-1 concentrations at 2 hours during pneumoperitoneum and after pneumoperitoneum being significantly lower in the observation group than in the control group ( P<0.05) . The gastrointestinal symptom score was lower in the observation group than in the control group, and the time to first flatus and first defecation was shorter in the observation group ( P<0.05) . Conclusion:The intraoperative administration of esketamine in laparoscopic total hysterectomy can promote postoperative gastrointestinal function recovery, reduce gastrointestinal symptom scores, and shorten the time to first flatus and first defecation.