Objective:To investigate the effect of computed tomography (CT)-guided minimally invasive drainage surgery on serum Omentin-1 and human astroglial derived protein (S100B) levels in patients with hypertensive intracerebral hemorrhage. Methods:A total of 120 patients with hypertensive intracerebral hemorrhage who were diagnosed in The First Affiliated Hospital of Harbin Medical University from January 2021 to December 2023 were included as the research subjects. According to the principle of random grouping,these patients were randomly divided into a study group and a control group,with 60 cases in each group. The study group adopted CT-located minimally invasive drainage surgery to conduct treatment,and the control group adopted conventional craniotomy to conduct treatment. The differences of curative effect,neurological function,cerebral edema,serum Omentin-1 and S100B levels between the two groups were compared. Results:In 60 patients of study group,45 cases showed significant improvement (75.00％),and 11 cases showed effective improvement (18.33％),and 4 cases showed invalid (6.67％),with an overall effective rate of 93.33％. In 60 patients of control group,6 cases showed significant improvement (10.00％),and 42 cases showed effective improvement (70.00％),and 12 cases showed invalid (20.00％),with an overall effective rate of 80.00％. The overall effective rate of study group was significantly higher than that of control group,and the difference was statistically significant (x2=4.621,P<0.05). The results of Glasgow Outcome Scale (GOS) scores of study group showed that 0 case was grade 1 (0.00％),and 6 cases were grade 2 (10.00％),and 10 cases were grade 3 (16.67％),and 2 cases were grade 4 (3.33％),and 42 cases were grade 5 (70.00％). At the 6th month after surgery,the GOS scores of control group indicated that 2 cases were grade 1 (3.33％),and 15 cases were grade 2 (25.00％),and 5 cases were grade 3 (8.33％),and 6 cases were grade 4 (10.00％),and 32 cases were grade 5 (53.33％). There was a statistically significant difference in GOS scores between the two groups (U=2.112,P<0.05). Both groups showed significant improvement in brain edema after surgery,and the volumes of brain edema at the 2nd week and the 1st month after surgery in study group were significantly lower than those in control group (t=41.675,29.750,P<0.05),respectively. Both groups obtained significant improvement in serum Omentin-1 and S100B levels,and the serum Omentin-1 and S100B levels after surgery in study group were significantly lower than those in control group,and the differences of them between two groups were significant (t=22.675,10.157,P<0.05),respectively. Conclusion:CT-located minimally invasive drainage surgery can effectively reduce the pressure at hemorrhagic region,and promote clearing hematoma through the precision CT-located guidance for patients with hypertensive intracerebral hemorrhage. At the same time,it can reduce cerebral edema,and relieve damage of brain tissue through regulates serum Omentin-1 and S100B levels. The postoperative recovery of neurological function is remarkable,and the overall treatment outcome is favorable.

Objective:To investigate the effect of computed tomography (CT)-guided minimally invasive drainage surgery on serum Omentin-1 and human astroglial derived protein (S100B) levels in patients with hypertensive intracerebral hemorrhage. Methods:A total of 120 patients with hypertensive intracerebral hemorrhage who were diagnosed in The First Affiliated Hospital of Harbin Medical University from January 2021 to December 2023 were included as the research subjects. According to the principle of random grouping,these patients were randomly divided into a study group and a control group,with 60 cases in each group. The study group adopted CT-located minimally invasive drainage surgery to conduct treatment,and the control group adopted conventional craniotomy to conduct treatment. The differences of curative effect,neurological function,cerebral edema,serum Omentin-1 and S100B levels between the two groups were compared. Results:In 60 patients of study group,45 cases showed significant improvement (75.00％),and 11 cases showed effective improvement (18.33％),and 4 cases showed invalid (6.67％),with an overall effective rate of 93.33％. In 60 patients of control group,6 cases showed significant improvement (10.00％),and 42 cases showed effective improvement (70.00％),and 12 cases showed invalid (20.00％),with an overall effective rate of 80.00％. The overall effective rate of study group was significantly higher than that of control group,and the difference was statistically significant (x2=4.621,P<0.05). The results of Glasgow Outcome Scale (GOS) scores of study group showed that 0 case was grade 1 (0.00％),and 6 cases were grade 2 (10.00％),and 10 cases were grade 3 (16.67％),and 2 cases were grade 4 (3.33％),and 42 cases were grade 5 (70.00％). At the 6th month after surgery,the GOS scores of control group indicated that 2 cases were grade 1 (3.33％),and 15 cases were grade 2 (25.00％),and 5 cases were grade 3 (8.33％),and 6 cases were grade 4 (10.00％),and 32 cases were grade 5 (53.33％). There was a statistically significant difference in GOS scores between the two groups (U=2.112,P<0.05). Both groups showed significant improvement in brain edema after surgery,and the volumes of brain edema at the 2nd week and the 1st month after surgery in study group were significantly lower than those in control group (t=41.675,29.750,P<0.05),respectively. Both groups obtained significant improvement in serum Omentin-1 and S100B levels,and the serum Omentin-1 and S100B levels after surgery in study group were significantly lower than those in control group,and the differences of them between two groups were significant (t=22.675,10.157,P<0.05),respectively. Conclusion:CT-located minimally invasive drainage surgery can effectively reduce the pressure at hemorrhagic region,and promote clearing hematoma through the precision CT-located guidance for patients with hypertensive intracerebral hemorrhage. At the same time,it can reduce cerebral edema,and relieve damage of brain tissue through regulates serum Omentin-1 and S100B levels. The postoperative recovery of neurological function is remarkable,and the overall treatment outcome is favorable.