Objective To investigate the influence of ultrasound-guided bilateral quadratus lumborum-pudendal nerve block combined with general anesthesia on analgesic effect after laparoscopic radical resection of colorectal cancer.Methods A total of 76 patients with laparoscopic radical resection of colorectal cancer from January 2025 to May 2025 were included.By using the single-double number method,they were divided into block general anesthesia group(double number,n=38)and conventional general anesthesia group(single number,n=38).The block general anesthesia group was treated with ultrasound-guided bilateral quadratus lumborum-pudendal nerve block combined with general anesthesia,while the conventional general anesthesia group was given conventional general anesthesia regimen.The anesthesia recovery indexes,hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP),and saturation of peripheral oxygen(SpO2)]before anesthesia,at the time of skin incision,skin suture,and the end of surgery,as well as the Visual Analogue Scale(VAS)score of pain at rest and activity and Riker Sedation-Agitation Scale score at 3,12,24,and 48 h after surgery,and levels of inflammatory factors and pain stress indexes before surgery and at 24 h after surgery were compared between the two groups.The adverse anesthesia reactions in the two groups were observed.Results The remifentanil dosage,sufentanil dosage,agitation rate,general anesthesia recovery time,first exhaust time,and remedial analgesia utilization rate in the block general anesthesia group were significantly lower or shorter than those in the conventional general anesthesia group(P<0.05).The HR and MAP were lower in the block general anesthesia group than those in the conventional general anesthesia group at the time of skin incision,skin suture,and the end of surgery(P<0.05),and there was no significant difference in SpO2(P>0.05).The VAS scores at rest and activity in the block general anesthesia group at 3,12,and 48 h after surgery were lower than those in the conventional general anesthesia group(P<0.05),and the Riker Sedation-Agitation Scale scores at 24 and 48 h after surgery were lower than those in the conventional general anesthesia group(P<0.05).At 24 h after surgery,the levels of interleukin-6,cortisol,and adrenocorticotropic hormone in the block general anesthesia group were lower than those in the conventional general anesthesia group(P<0.05).The total incidence rates of adverse anesthesia reactions in the block general anesthesia group[7.9%(3/38)]was significantly lower than that in the conventional general anesthesia group[26.3%(10/38),P=0.033].Conclusions The application of ultrasound-guided bilateral quadratus lumborum-pudendal nerve block combined with general anesthesia during laparoscopic radical resection of colorectal cancer has good analgesic and sedative effects.It has small influence on hemodynamics,reduces the dosages of opioids,relieves the inflammatory stress response,and reduces the adverse reactions.

Objective To investigate the influence of ultrasound-guided bilateral quadratus lumborum-pudendal nerve block combined with general anesthesia on analgesic effect after laparoscopic radical resection of colorectal cancer.Methods A total of 76 patients with laparoscopic radical resection of colorectal cancer from January 2025 to May 2025 were included.By using the single-double number method,they were divided into block general anesthesia group(double number,n=38)and conventional general anesthesia group(single number,n=38).The block general anesthesia group was treated with ultrasound-guided bilateral quadratus lumborum-pudendal nerve block combined with general anesthesia,while the conventional general anesthesia group was given conventional general anesthesia regimen.The anesthesia recovery indexes,hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP),and saturation of peripheral oxygen(SpO2)]before anesthesia,at the time of skin incision,skin suture,and the end of surgery,as well as the Visual Analogue Scale(VAS)score of pain at rest and activity and Riker Sedation-Agitation Scale score at 3,12,24,and 48 h after surgery,and levels of inflammatory factors and pain stress indexes before surgery and at 24 h after surgery were compared between the two groups.The adverse anesthesia reactions in the two groups were observed.Results The remifentanil dosage,sufentanil dosage,agitation rate,general anesthesia recovery time,first exhaust time,and remedial analgesia utilization rate in the block general anesthesia group were significantly lower or shorter than those in the conventional general anesthesia group(P<0.05).The HR and MAP were lower in the block general anesthesia group than those in the conventional general anesthesia group at the time of skin incision,skin suture,and the end of surgery(P<0.05),and there was no significant difference in SpO2(P>0.05).The VAS scores at rest and activity in the block general anesthesia group at 3,12,and 48 h after surgery were lower than those in the conventional general anesthesia group(P<0.05),and the Riker Sedation-Agitation Scale scores at 24 and 48 h after surgery were lower than those in the conventional general anesthesia group(P<0.05).At 24 h after surgery,the levels of interleukin-6,cortisol,and adrenocorticotropic hormone in the block general anesthesia group were lower than those in the conventional general anesthesia group(P<0.05).The total incidence rates of adverse anesthesia reactions in the block general anesthesia group[7.9%(3/38)]was significantly lower than that in the conventional general anesthesia group[26.3%(10/38),P=0.033].Conclusions The application of ultrasound-guided bilateral quadratus lumborum-pudendal nerve block combined with general anesthesia during laparoscopic radical resection of colorectal cancer has good analgesic and sedative effects.It has small influence on hemodynamics,reduces the dosages of opioids,relieves the inflammatory stress response,and reduces the adverse reactions.

Objective: To investigate the incidence and treatment of perioperative anemia in patients with gastrointestinal neoplasms in Hubei Province. Methods: The clinicopathological data of 7 474 patients with gastrointestinal neoplasms in 62 hospitals in 15 cities (state) of Hubei Province in 2019 were collected in the form of network database. There were 4 749 males and 2 725 females. The median age of the patients was 62 years (range: 17 to 96 years). The hemoglobin value of the first time in hospital and the first day after operation was used as the criterion of preoperative anemia and postoperative anemia. Anemia was defined as male hemoglobin <120 g/L and female hemoglobin <110.0 g/L, mild anemia as 90 to normal, moderate anemia as 60 to <90 g/L, severe anemia as <60 g/L. The t test and χ² test were used for inter-group comparison. Results: The overall incidence of preoperative anemia was 38.60%(2 885/7 474), and the incidences of mild anemia, moderate anemia and severe anemia were 25.09%(1 875/7 474), 11.37%(850/7 474) and 2.14%(160/7 474), respectively. The overall incidence of postoperative anemia was 61.40%(4 589/7 474). The incidence of mild anemia, moderate anemia and severe anemia were 48.73%(3 642/7 474), 12.20%(912/7 474) and 0.47%(35/7 474), respectively. The proportion of preoperative anemia patients receiving treatment was 26.86% (775/2 885), and the proportion of postoperative anemia patients receiving treatment was 14.93% (685/4 589). The proportions of preoperative anemia patients in grade ⅢA, grade ⅢB, and grade ⅡA hospitals receiving treatment were 26.12% (649/2 485), 32.32% (85/263), and 29.93% (41/137), and the proportions of postoperative anemia patients receiving treatment were 14.61% (592/4 052), 22.05% (73/331), and 9.71% (20/206). The proportion of intraoperative blood transfusion (16.74% (483/2 885) vs. 3.05% (140/4 589), χ²=434.555, P<0.01) and the incidence of postoperative complications (17.78% (513/2 885) vs. 14.08% (646/4 589), χ²=18.553, P<0.01) in the preoperative anemia group were higher than those in the non-anemia group, and the postoperative hospital stay in the preoperative anemia group was longer than that in the non-anemia group ((14.1±7.3) days vs. (13.3±6.2) days, t=5.202, P<0.01). Conclusions: The incidence of perioperative anemia in patients with gastrointestinal neoplasms is high. Preoperative anemia can increase the demand for intraoperative blood transfusion and affect the short-term prognosis of patients. At present, the concept of standardized treatment of perioperative anemia among gastrointestinal surgeons in Hubei Province needs to be improved.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anemia/epidemiology* ; Blood Transfusion ; Female ; Gastrointestinal Neoplasms/surgery* ; Humans ; Length of Stay ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Young Adult