Objective To observe the clinical efficacy of therapy of tonifying heart and spleen for the treatment of patients with postpartum depression of heart and spleen deficiency syndrome based on the theory of intestinal flora-neurotransmitter-brain axis(shortened as brain-intestine axis),and to explore its effect on the improvement of patients'depression and anxiety.Methods A total of 136 patients with postpartum depression of heart and spleen deficiency syndrome who admitted to The 908th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China from June 2021 to July 2023 were randomly divided into the conventional treatment group(control group)and the tonifying heart-spleen group(observation group)according to the random number table method,with 68 cases in each group.The control group was treated with conventional antidepressant drugs,and the observation group was treated with therapy of tonifying heart and spleen by utilization of Shen Qi Jieyu Prescription Granules)on the basis of treatment for the control group.Both groups were treated for six continuous weeks.Before and after the treatment,the two groups were observed in the changes of main symptom scores of traditional Chinese medicine(TCM)syndrome,Hamilton Depression Scale(HAMD)scores,7-Item Generalized Anxiety Disorder Scale(GAD-7)scores,and the levels of serum neurotransmitters of 5-hydroxytryptamine(5-HT),dopamine(DA),norepinephrine(NE),as well as microflora metabolites such as short-chain fatty acids(SCFAs),glutamic acid(GLU),gamma-aminobutyric acid(GABA).Moreover,the clinical efficacy and safety of the two groups of patients were evaluated.Results(1)After six weeks of treatment,the total effective rate of the observation group was 89.71%(61/68)and that of the control group was 73.53%(50/68),and the intergroup comparison(tested by chi-square test)showed that the efficacy of the observation group was significantly superior to that of the control group(P<0.05).(2)After treatment,the scores of TCM syndrome main symptoms such as emotional upset,slow thinking,poor appetite,abdominal distension and loose stools in the two groups were decreased compared with those before treatment(P<0.05),and the decrease in the observation group was significantly superior to that in the control group(P<0.01).(3)After treatment,the HAMD scores and GAD-7 scores in the two groups of patients were all decreased compared with those before treatment(P<0.05),and the decrease in the observation group was significantly superior to that in the control group(P<0.01).(4)After treatment,the serum levels of neurotransmitters 5-HT,DA,and NE in the two groups of patients were all increased compared with those before treatment(P<0.05),and the increase in the observation group was significantly superior to that in the control group(P<0.01).(5)After treatment,the serum levels of microflora metabolites SCFAs,GLU and GABA in the two groups of patients were all increased compared with those before treatment(P<0.05),and the increase in the observation group was significantly superior to that in the control group(P<0.01).(6)The incidence of adverse reactions in the observation group was 8.82%(6/68)and that in the control group was 5.88%(4/68),and the intergroup comparison showed that the difference was not statistically significant(P>0.05).Conclusion The application of therapy of tonifying heart and spleen for the treatment of patients with postpartum depression of heart and spleen deficiency syndrome based on brain-intestine axis exerts certain efficacy and safety through correcting the imbalance of neurotransmitters and regulating the microflora metabolites of the patients,thus to alleviate depression and anxiety.

Objective To observe the clinical efficacy of thumb-tack needling for subcutaneous embedding combined with repetitive transcranial magnetic stimulation(rTMS)in the treatment of post-stroke dysphagia.Methods A total of 120 cases of patients with post-stroke dysphagia admitted to the 908th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China from February 2022 to February 2024 were randomly divided into the observation group and the control group according to random number table method,with 60 cases in each group.Both groups of patients were given conventional symptomatic supportive treatment,such as trophic nerve,improving circulation,etc.,and the control group was given high-frequency rTMS treatment,while the observation group was treated with thumb-tack needling for subcutaneous embedding therapy on the basis of the treatment in the control group.The course of treatment covered four weeks continuously.After one month of treatment,the clinical efficacy of the two groups was evaluated,and the changes in scores of traditional Chinese medicine(TCM)syndrome,Functional Oral Intake Scale(FOIS)and Standardized Swallowing Assessment(SSA),as well as levels of serum total protein(TP),serum albumin(ALB),and hemoglobin(Hb)before and after treatment were observed in the patients of the two groups.The changes in swallowing wave amplitude and swallowing duration before and after treatment were compared between the two groups of patients.Results(1)During the study,there were none in the observation group and eight cases in the control group were failed to follow-up.Finally,64 cases in the observation group and 56 cases in the control group were included in the efficacy statistics.(2)The total effective rate was 92.19%(59/64)in the observation group and 76.79%(43/56)in the control group,and the efficacy of the observation group was superior to that of the control group,the difference being statistically significant(P<0.05).(3)After treatment,the TCM syndrome scores of the patients in the two groups were significantly improved(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,with statistically significant differences(P<0.05).(4)After treatment,the FOIS score and SSA score of the patients in the two groups improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(5)After treatment,the swallowing wave amplitude and swallowing duration of patients in the two groups improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,the difference being statistically significant(P<0.05).(6)After treatment,the TP,ALB and Hb levels of patients in the two groups improved significantly(P<0.05),and the improvement in the observation group was significantly superior to that in the control group,with statistically significant differences(P<0.05).Conclusion Thumb-tack needling for subcutaneous embedding combined with rTMS in the treatment of post-stroke dysphagia can significantly shorten the patients'swallowing duration and enlarge the swallowing wave amplitude,thus improving their swallowing function and improving their quality of life.

OBJECTIVE: To explore the correlation between the cognition on hearing protection and mental health status of noise-exposed workers. METHODS: A total of 499 noise-exposed workers from 3 enterprises of coal mine, steel and textile in Xinjiang region were selected as study subjects by stratified cluster random sampling method. The cognitive status of hearing protection and mental health status of each group were investigated by the Workplace Health Promotion Pilot Project Questionnaire. RESULTS: A total of 235 workers had abnormal mental health status.The abnormal rate of mental health status was 47.1%(235/499). The results of logistic regression analysis showed that female, age ≤40.0 years, unable to bear current noise hazards, worried about noise-induced-deafness and noise-induced discomfort were the risk factors of abnormality of mental health status(odds ratio values were 1.62, 1.87, 2.42, 2.20, 2.14, P<0.05). Using hearing protectors for ≥3.0 years was the protective factor of abnormality of mental health status(odds ratio value was 0.47, P<0.05). CONCLUSION: The subjective cognition on hearing protection has an impact on the mental health of noise-exposed workers.

Objective: To compare the knowledge and behavior toward hearing protection among workers in different workplaces and investigate its influence factors. Methods: 2 manufacturing companies with obvious noise hazard in workplace were selected into the study. Health management level was distinguished through field investigation and verification. Questionnaire focus on basic knowledge of hearing health, acceptance level of noise hazard, comfort of wearing hearing protectors and atmosphere in workplace was designed and was used to investigate the knowledge and behavior toward hearing protection. Results: Hearing protectors that meet the level of protection are distributed throughout the workplaces. Although company A has a lower noise hazards level, the health management system was poorly executed. The proportion of workers persisting in wearing hearing protectors throughout the work shift in company A was lower than B (P<0.01) . Workers in company A intended to underestimate the noise level (P<0.01) and the health effect of hearing loss (P<0.01) . All the workers were worry about suffering from hearing loss (P>0.05) , but those in company B had more positive attitude toward the protection of hearing protector (P<0.01) and relied on the protector (P<0.01) . The awareness of protection, in turn, help workers adapt attitude and get used to wearing hearing protectors consciously in workplace (P<0.01) . Conclusion Health management performance play a key role in help workers form good knowledge and behavior. To protect workplace health, employers need to creative a healthy supportive environment for workers.

Objective To analyze changes in serum levels of inflammatory factors,galectin-3 (Gal-3),fractalkine(FKN) and interleukin-6 (IL-6),in patients with dilated cardiomyopathy (DCM) or ischemic cardiomyopathy (ICM),and to explore their clinical significance.Methods Seventy-six hospitalized patients with DCM were selected to serve as a DCM group,and 78 patients with ischemic cardiomyopathy were selected into an ICM group from October 2016 to December 2017 at the Department of Cardiology,and patients in the two groups received cardiac function classification.Meanwhile,82 healthy people were included as a control group.Fasting venous blood was collected,and serum levels of Gal-3,FKN,IL-6,and BNP were measured.The correlations of Gal-3,FKN,and IL-6 with DCM or ICM were analyzed.Results Levels of plasma BNP and serum Gal-3,FKN,and IL-6 in the DCM and ICM groups were higher than those in the control group,and their levels in the DCM group were significantly higher than in the ICM group.Levels of plasma BNP and serum Gal-3,FKN,and IL-6 increased as their New York Heart Association(NYHA)classification went higher in both the DCM and ICM groups.For patients classified at the same level,serum levels of Gal-3,FKN,and IL-6 of the DCM group were significantly higher than those of the ICM group(P ＜ 0.05).BNP levels showed no difference between the two groups(P ＞0.05).Spearman correlation analysis indicated positive correlations of NYHA classification with levels of BNP(r =0.30,0.19),Gal-3(r=0.24,0.19),FKN(r =0.63,0.51),and IL-6(r =0.28,0.15)in both the DCM and ICM groups(P ＜ 0.05),and the correlation was stronger in the DCM group.Conclusions Increased expression of plasma BNP,Gal-3,FKN,and IL-6 in patients with DCM and ICM are closely related to the severity of cardiac function impairment.Monitoring changes in levels of plasma BNP and serum inflammatory factors Gal-3,FKN and IL-6 provides important clues for the differential diagnosis between DCM and ICM,the assessment of clinical conditions and treatment-related decisions.

Objective To investigate the distribution and antimicrobial resistance profile of the common pathogens isolated during the period from 2009 to 2015.Methods All the bacterial strains isolated from pediatric inpatients in Beijing Children's Hospital during the period from 2009 to 2015 were analyzed. Antimicrobial susceptibility was determined by disk diffusion method and Phoenix 100 Automated Microbiology System. Results were analyzed according to the guidelines of CLSI (2014) using WHONET 5.6 software.Results The total strains were 26630. The most common gram-positive isolates were Streptococcus pneumoniae,Staphylococcusaureusand coagulase-negative Staphylococcus (CNS), while the most frequently isolated gram-negative microorganisms were Klebsiella spp.,Pseudomonas aeruginosa and Escherichia coli. The prevalence of S. pneumoniae was up to 25.7 % (4101/15973) in all respiratory tract specimens. About 50.2 % of the S. pneumoniae isolates were not susceptible to penicillin. The prevalence of methicillin-resistant strains was 20.6 % in S. aureus (MRSA) and 87.8 % in coagulase negative Staphylococcus (MRCNS) on average. The prevalence of MRSA increased from 11.1 % in 2009 to 29.8 % in 2015. No S. pneumoniae or staphylococcal strains were found resistant to vancomycin or linezolid. The Enterococcus strains were still highly susceptible to vancomycin and linezolid. Overall 0.3 % of the Enterococcus faecium isolates were resistant to vancomycin. The extended-spectrum beta-lactamases (ESBLs) producing strains accounted for 71.4 % -78.1 % of E. coli and 65.1 % - 76.9 % of K. pneumoniae isolates. The carbapenem-resistant E. coli and K. pneumoniae were reported for the first time in 2010, but in 2014, the strains resistant to carbapenems had increased to more than 7 % in E. coli, and higher than 20 % in K. pneumoniae. In 2015, up to 27.7 % and 25.7 % of P. aeruginosa isolates were resistant to imipenem and meropenem, respectively, and 59.9 % of the A. baumannii isolates were resistant to imipenem and meropenem. Beta-lactamase was positive in 46.3 % of the H. influenzae isolates. Conclusions MRSA and the carbapenem-resistant strains of E. coli,K. pneumoniae and A. baumannii are still on the rise in pediatric inpatients, which poses a serious threat to clinical practice and implies the importance of strengthening infection control.

Primary immunodeficiency diseases (PIDs) represent a typical group of rare diseases with high mortality and disability with regard to long-term outcome.Saving life and improving quality of life of the patients with PID remain to be the responsibility of the stakeholders from all aspects of the society.As the central player in the long run of PID campaign,pediatric immunologists should play a critical role in providing key epidemiological data in favor of political decision-making and social resource distribution.

Objective To observe the effects and characteristics of vestibular illusions and vestibular autonomic reactions induced by short arm centrifuge exposure,and to search the appropriate rotation speed of short arm centrifuge for vestibular illusion simulation training on the ground.Methods Ninety healthy pilots were divided into 3 groups by the rotation speed of 21,30 and 37 r/min that generated by SAC-Ⅲ short arm centrifuge.By referencing the vestibular illusions simulation training on electric rotating chair,they were exposure to the simulation of counter-rotatory illusion and Coriolis illusion.Vestibular illusions and vestibular autonomic reactions were compared.Results ①When the speed was 21 r/min,the induced rates of the counter-rotatory illusion,Coriolis tumbling illusion (including head turn to right and to left) and Coriolis somatogyral illusion (including head pitched up and down) were lower than the induced rates under the speed of 30 r/min and 37 r/min (X2＝6.477 20.000,P＜0.01 or P＜0.05).And when the speed was 30 r/min and 37 r/min,the induced rates showed no significant difference (x2 ＝0.073-0.351,P＞0.05).②The expressions and characteristics of the centrifuge evoked counter-rotatory illusion were approximately the same under three different rotation speeds,while the illusion strength was enhanced with the speed increase.The expressions and characteristics of the Coriolis tumbling illusion induced by different speed showed no significant difference (X2 ＝0.090,0.056,P＞0.05).And the expressions of the Coriolis somatogyral illusions were multiform.Under three different speeds,the Coriolis somatogyral illusions showed no significant difference when the pilot's head pitched down (X2 ＝ 1.810,P＞0.05).The case of Coriolis somatogyral illusions was very rare when pilot's head pitched up and the result was not taken into account.③The scores of vestibular autonomic reaction were increased with the rotation speed increase,and showed significant difference (F＝ 15.058,P＜0.01).When the speed was 37 r/min,the score of vestibular autonomic reaction was significantly higher than the scores of 21 r/min and 30 r/min (P＜0.01 or P＜0.05),and there was no significant difference between the scores of 21 r/min and 30 r/min (P＞0.05).Conclusions When the speed of centrifuge was 30 r/m in,the induced rate of the vestibular illusions was the highest and the vestibular autonomic reaction was mild.For the 2 m arm centrifuge,the 30 r/min rotation was appropriate for pilots' vestibular illusion simulation training on the ground.

Objective To observe the effects and characteristics of vestibular illusions and vestibular autonomic reactions induced by short arm centrifuge exposure,and to search the appropriate rotation speed of short arm centrifuge for vestibular illusion simulation training on the ground.Methods Ninety healthy pilots were divided into 3 groups by the rotation speed of 21,30 and 37 r/min that generated by SAC-Ⅲ short arm centrifuge.By referencing the vestibular illusions simulation training on electric rotating chair,they were exposure to the simulation of counter-rotatory illusion and Coriolis illusion.Vestibular illusions and vestibular autonomic reactions were compared.Results ①When the speed was 21 r/min,the induced rates of the counter-rotatory illusion,Coriolis tumbling illusion (including head turn to right and to left) and Coriolis somatogyral illusion (including head pitched up and down) were lower than the induced rates under the speed of 30 r/min and 37 r/min (X2＝6.477 20.000,P＜0.01 or P＜0.05).And when the speed was 30 r/min and 37 r/min,the induced rates showed no significant difference (x2 ＝0.073-0.351,P＞0.05).②The expressions and characteristics of the centrifuge evoked counter-rotatory illusion were approximately the same under three different rotation speeds,while the illusion strength was enhanced with the speed increase.The expressions and characteristics of the Coriolis tumbling illusion induced by different speed showed no significant difference (X2 ＝0.090,0.056,P＞0.05).And the expressions of the Coriolis somatogyral illusions were multiform.Under three different speeds,the Coriolis somatogyral illusions showed no significant difference when the pilot's head pitched down (X2 ＝ 1.810,P＞0.05).The case of Coriolis somatogyral illusions was very rare when pilot's head pitched up and the result was not taken into account.③The scores of vestibular autonomic reaction were increased with the rotation speed increase,and showed significant difference (F＝ 15.058,P＜0.01).When the speed was 37 r/min,the score of vestibular autonomic reaction was significantly higher than the scores of 21 r/min and 30 r/min (P＜0.01 or P＜0.05),and there was no significant difference between the scores of 21 r/min and 30 r/min (P＞0.05).Conclusions When the speed of centrifuge was 30 r/m in,the induced rate of the vestibular illusions was the highest and the vestibular autonomic reaction was mild.For the 2 m arm centrifuge,the 30 r/min rotation was appropriate for pilots' vestibular illusion simulation training on the ground.

Objective To investigate the feasibility, rationality and efficacy of the autologous dermal-fat composite tissue used as filling materials in the repair of nasal dorsum collapse.Methods The dermal fat composite tissue block (7.0 cm× 1.0 cm × 1.0 cm) was removed from the buttocks or abdoman as filling materials. 13 cases of nasal dorsum and nasal-shaped misfits were treated by using an umbrella graft of the auricular cartilage plus dermal-fat composite tissue graft to reconstruct natual shape of nasal dorsum and tip. Results The nasal dorsum and tip were repaired in 13 patients with collapsed nasal dorsum. The dermal-fat composite tissue survived well, and the incisions were healed in stage Ⅰ and the incision trace was not obvious. After follow-up for one year, the shape of nose was much satisfactory. Conclusion It is a well-accepted and easy-going procedure to repair collapsed nasal dorsum with autologous dermal-fat or a combination of composite ear cartilage tissue graft, with satisfactory effect and no rejection reactions.