Objective:To explore clinically therapeutic effect and complications of argon plasma coagulation (APC) under gastrointestinal endoscope in gastroduodenal bleeding. Methods:A total of 206 patients with gastroduodenal bleeding who admitted to Tangdu Hospital from January 2021 to December 2023 were selected,and they were divided into control group and observation group according to the single and double numbers of outpatient registration,with 103 cases in each group. The control group was treated with injection hemostasis under gastrointestinal endoscope,and the observation group was treated with APC treatment under gastrointestinal endoscope. The surgical efficacies,the levels of stress reaction indicators and incidences of complication between two groups were compared. Results:In 103 cases of observation group,56 cases occurred significant effect,and 42 cases were valid,and 5 cases were invalid,and the total efficiency rate of treatment was 95.15％. In 103 cases of control group,35 cases occurred significant effect,and 49 cases were valid,and 19 cases were invalid,and the total efficiency rate of treatment was 81.55％,and the difference was significant (x2=9.244,P<0.05). The intraoperative bleeding and blood transfusion volume of observation group were lower than those of control group,and hemostasis time and hospitalization time of observation group were shorter than those of control group,and the differences of them were significant (t=16.668,38.022,26.405,29.073,P<0.05),respectively. After 1d of surgery,the stress reaction indicators of the two groups reduced,and the levels of cortisol (Cor),malondialdehyde (MDA),norepinephrine (NE) and adrenaline (E) of observation group were lower than those of control group (t=20.777,68.462,13.510,14.791,P<0.05),respectively. The incidence of the complications of observation group were 5.83％,which was significantly lower than that (15.53％) of control group (x2=5.089,P<0.05). Conclusion:Gastrointestinal endoscopic APC can improve the therapeutic effect of gastroduodenal bleeding,and alleviate the stress reaction,and reduce the complications.

Objective:To explore clinically therapeutic effect and complications of argon plasma coagulation (APC) under gastrointestinal endoscope in gastroduodenal bleeding. Methods:A total of 206 patients with gastroduodenal bleeding who admitted to Tangdu Hospital from January 2021 to December 2023 were selected,and they were divided into control group and observation group according to the single and double numbers of outpatient registration,with 103 cases in each group. The control group was treated with injection hemostasis under gastrointestinal endoscope,and the observation group was treated with APC treatment under gastrointestinal endoscope. The surgical efficacies,the levels of stress reaction indicators and incidences of complication between two groups were compared. Results:In 103 cases of observation group,56 cases occurred significant effect,and 42 cases were valid,and 5 cases were invalid,and the total efficiency rate of treatment was 95.15％. In 103 cases of control group,35 cases occurred significant effect,and 49 cases were valid,and 19 cases were invalid,and the total efficiency rate of treatment was 81.55％,and the difference was significant (x2=9.244,P<0.05). The intraoperative bleeding and blood transfusion volume of observation group were lower than those of control group,and hemostasis time and hospitalization time of observation group were shorter than those of control group,and the differences of them were significant (t=16.668,38.022,26.405,29.073,P<0.05),respectively. After 1d of surgery,the stress reaction indicators of the two groups reduced,and the levels of cortisol (Cor),malondialdehyde (MDA),norepinephrine (NE) and adrenaline (E) of observation group were lower than those of control group (t=20.777,68.462,13.510,14.791,P<0.05),respectively. The incidence of the complications of observation group were 5.83％,which was significantly lower than that (15.53％) of control group (x2=5.089,P<0.05). Conclusion:Gastrointestinal endoscopic APC can improve the therapeutic effect of gastroduodenal bleeding,and alleviate the stress reaction,and reduce the complications.

China is a country with a high incidence of esophageal cancer.The pathological type is mainly squamous cell carcinoma.Squamous intraepithelial neoplasia is the most recognized precancerous lesion of esopha-geal squamous cell carcinoma,and its monitoring and intervention is an effective method to reduce the incidence of esophageal squamous cell carcinoma and improve the quality of life of patients.Understanding the etiology,clinical features,diagnosis and treatment of esophageal squamous cell carcinoma plays a crucial role in the prevention and early diagnosis and treatment of esophageal squamous cell carcinoma.At present,the clinical research related to esophageal squamous intraepithelial neoplasia is still insufficient,and there are some differences in clinical treat-ment.This review summarizes the risk factors,clinical features,diagnosis,prognosis and treatment of esophageal squamous intraepithelial neoplasia,hoping to provide ideas for the clinical management of esophageal squamous intraepithelial neoplasia.