The safety system of human sperm bank is not only directly associated with the working normality of the sperm bank and the reproductive safety of insemination project, but also deeply related to the reproductive health and eugenics of the offspring. Human sperm banks in China have been formally worked for over 20 years. However, some safety problems or risks in sperm banks have been inevitably exposed during the working period. Thus, safety problems or risks of the sperm bank should be fully given attention. In this paper, potential safety problems or risks of the sperm bank were illustrated on aspects of management safety, reproductive safety, and genetic safety. In addition, views on the possible improvement of safety system were given including strengthening supervision for the sperm bank from governmental agencies, promoting academic exchange of sperm banks at home and abroad, and applying new gene sequencing techniques etc. Paying more attention on the construction of the safety system can prevent the potential safety problems or risks in sperm banks, promote high quality male fertility preservation and ensure both reproductive safety and health of assisted reproductive programs. It has positive practical significance and far-reaching social influence.

The safety system of human sperm bank is not only directly associated with the working normality of the sperm bank and the reproductive safety of insemination project, but also deeply related to the reproductive health and eugenics of the offspring. Human sperm banks in China have been formally worked for over 20 years. However, some safety problems or risks in sperm banks have been inevitably exposed during the working period. Thus, safety problems or risks of the sperm bank should be fully given attention. In this paper, potential safety problems or risks of the sperm bank were illustrated on aspects of management safety, reproductive safety, and genetic safety. In addition, views on the possible improvement of safety system were given including strengthening supervision for the sperm bank from governmental agencies, promoting academic exchange of sperm banks at home and abroad, and applying new gene sequencing techniques etc. Paying more attention on the construction of the safety system can prevent the potential safety problems or risks in sperm banks, promote high quality male fertility preservation and ensure both reproductive safety and health of assisted reproductive programs. It has positive practical significance and far-reaching social influence.

Since 1984, Indian medical experts reported that reversible inhibition of sperm under guidance (RISUG) had a good effect in male contraception, and was announced as a male contraceptive which could relieve female contraceptive pain, the international research on RISUG male contraceptive had been done nearly for 40 years. However, different studies had reported that the results were very different. Some scholars reported that the effect of the drug was not obvious, and some scholars reported that the side effects of the drug were too serious to be studied in depth. Therefore, the effectiveness and safety of the drug had always been the focus of debate, so its clinical progress was slow. In addition to the effect of the drug, its safety also needed to be further explored and analyzed. In this paper, the research background, action mechanism, experimental basis, research methods (including administration mode, administration and dose, onset time, action and effect, reversal mode and effect, safety evaluation, etc.), as well as the problems and development prospects of RISUG male contraceptive needle were reviewed.

Since 1984, Indian medical experts reported that reversible inhibition of sperm under guidance (RISUG) had a good effect in male contraception, and was announced as a male contraceptive which could relieve female contraceptive pain, the international research on RISUG male contraceptive had been done nearly for 40 years. However, different studies had reported that the results were very different. Some scholars reported that the effect of the drug was not obvious, and some scholars reported that the side effects of the drug were too serious to be studied in depth. Therefore, the effectiveness and safety of the drug had always been the focus of debate, so its clinical progress was slow. In addition to the effect of the drug, its safety also needed to be further explored and analyzed. In this paper, the research background, action mechanism, experimental basis, research methods (including administration mode, administration and dose, onset time, action and effect, reversal mode and effect, safety evaluation, etc.), as well as the problems and development prospects of RISUG male contraceptive needle were reviewed.

Objective To discover biological markers of male infertility.Methods Two-dimensional electrophoresis and Mass-Spectrum techniques(MS+MS/MS) were used for analyzing the seminal plasma from idiopathic male infertility and the control.Results Serum albumin and prostatic acid phosphatase were reduced in seminal plasma from idiopathic male infertility,while Cathepsin B and Zn-alpha-2-glycoprotein were increased.ConclusionIdiopathic male infertility was potentially associated with disorder of sperm capacitation and seminal immune function.