1.Erratum: Author correction to "Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice" Acta Pharm Sin B 11 (2021) 1200-1212.
Yuyu ZHU ; Ning WAN ; Xinni SHAN ; Guoliang DENG ; Qiang XU ; Hui YE ; Yang SUN
Acta Pharmaceutica Sinica B 2025;15(3):1719-1720
[This corrects the article DOI: 10.1016/j.apsb.2020.12.008.].
2.Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice.
Yuyu ZHU ; Ning WAN ; Xinni SHAN ; Guoliang DENG ; Qiang XU ; Hui YE ; Yang SUN
Acta Pharmaceutica Sinica B 2021;11(5):1200-1212
Metabolic syndrome is a clustering of metabolic disorder with unclear molecular mechanism. Increasing studies have found that the pathogenesis and progression of metabolic syndrome are closely related to inflammation. Here, we report celastrol, a traditional Chinese medicine, can improve high fat diet-induced metabolic syndrome through suppressing resistin-induced inflammation. Mechanistically, celastrol binds to adenylyl cyclase associated protein 1 (CAP1) and inhibits the interaction between CAP1 and resistin, which restrains the cyclic adenylate monophosphate (cAMP)-protein kinase A (PKA)-nuclear factor kappa-B (NF-
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