Hyperbranched polymers (HBPs) have drawn great interest in the biomedical field on account of their special morphology, low viscosity, self-regulation, and facile preparation methods. Moreover, their large intramolecular cavities, high biocompatibility, biodegradability, and targeting properties render them very suitable for anti-tumor drug delivery. Recently, exploiting the specific characteristics of the tumor microenvironment, a range of multifunctional HBPs responsive to the tumor microenvironment have emerged. By further introducing various types of drugs through physical embedding or chemical coupling, the resulting HBPs based delivery systems have played a crucial part in improving drug stability, increasing effective drug concentration, decreasing drug toxicity and side effects, and enhancing anti-tumor effect. Here, based on different types of tumor microenvironment stimulation signals such as pH, redox, temperature, etc., we systematically review the preparation and response mechanism of HBPs, summarize the latest advances in drug delivery applications, and analyze the challenges and future research directions for such nanomaterials in biomedical clinical applications.

Hyperbranched polymers(HBPs)have drawn great interest in the biomedical field on account of their special morphology,low viscosity,self-regulation,and facile preparation methods.Moreover,their large intramolecular cavities,high biocompatibility,biodegradability,and targeting properties render them very suitable for anti-tumor drug delivery.Recently,exploiting the specific characteristics of the tumor microenvironment,a range of multifunctional HBPs responsive to the tumor microenvironment have emerged.By further introducing various types of drugs through physical embedding or chemical coupling,the resulting HBPs based delivery systems have played a crucial part in improving drug sta-bility,increasing effective drug concentration,decreasing drug toxicity and side effects,and enhancing anti-tumor effect.Here,based on different types of tumor microenvironment stimulation signals such as pH,redox,temperature,etc,we systematically review the preparation and response mechanism of HBPs,summarize the latest advances in drug delivery applications,and analyze the challenges and future research directions for such nanomaterials in biomedical clinical applications.

Objective:To analyze the clinical characteristics, diagnosis and treatment of post-traumatic stress disorder (PTSD) in military flying personnel.Methods:The clinical treatment process of a helicopter navigator with PTSD were reported and the related literatures were reviewed.Results:The direct inducement of this case was that the helicopter navigator experienced the influence of a first-class flight accident. The main clinical manifestations of this case were repeated traumatic experience, low mood, decreased interest and continuously increased alertness, such as difficulty in falling asleep and nightmares, which met the diagnostic criteria for PTSD. After drugs with psychological treatment, the patient was clinically cured. After the observation on ground, the patient was qualified for flight.Conclusions:Emphasis should be placed on psychological screening to improve the diagnostic awareness of PTSD in military flying personnel. Drugs with psychological treatment may be a good method to cure such diseases.

Objective:To analyze the clinical characteristics, diagnosis and treatment of post-traumatic stress disorder (PTSD) in military flying personnel.Methods:The clinical treatment process of a helicopter navigator with PTSD were reported and the related literatures were reviewed.Results:The direct inducement of this case was that the helicopter navigator experienced the influence of a first-class flight accident. The main clinical manifestations of this case were repeated traumatic experience, low mood, decreased interest and continuously increased alertness, such as difficulty in falling asleep and nightmares, which met the diagnostic criteria for PTSD. After drugs with psychological treatment, the patient was clinically cured. After the observation on ground, the patient was qualified for flight.Conclusions:Emphasis should be placed on psychological screening to improve the diagnostic awareness of PTSD in military flying personnel. Drugs with psychological treatment may be a good method to cure such diseases.