Objective:To evaluate corrective effect of cone beam computed tomography(CBCT)in children with malocclusion during mixed dentition period.Methods:A total of 90 children with malocclusion during mixed dentition period who admitted to 3201th hospital between January and December 2023 were enrolled,and all of them underwent routine orthodontics.Before and after treatment,CBCT scan was performed to obtain oral and maxillofacial imaging data.According to measurement and analysis for imaging data,the corrective effect,the relation indicators between sagittal and vertical directions of jawbone,which included the constructed angle among the center point of sella turcica-nasion-superior alveolar seat(SNA),the constructed angle among the center point of sella turcica-nasion-inferior alveolar seat(SNB),the constructed angle among superior alveolar seat-nasion-inferior alveolar seat(ANB),the constructed angle between occlusal plane and sella-nasion plane(OP-SN),the angle between mandibular plane and extended line of occlusal plane(SN-MP),were assessed.In addition,the other related mandibular indicators included the angle(Y axis angle)between Y axis and orbitoauricular plane,the angle of nasion A point line-orbitale-pterygomaxillary fissure line(NA-Apo),gonion-pogonion length(Go-Pg),the distance values(Wits)between anterior nasal crest and orbitomeatal plane,and between posterior nasal crest and orbitomeatal plane also were assessed.Third,the soft tissue-related indicators,which included the distance(UL-EP)between upper lip protrusion point,nasal protrusion point and soft tissue line,and the distance(LL-EP)between lower lip protrusion point,nasal protrusion point and soft tissue line,and the nasal labial angle(NLA),the lower intersection angle between the line connecting the nasal columella point and the infranasal point,and the lower intersection angle between the line connecting the nasal columella point and upper lip protrusion point,and the angle(H)between H line and soft tissue surface angle,were assessed.Finally,the dentally relative indicators,which included incisor mandibular plane angle(IMPA angle),upper central incisor-sella nasion plane angle(U1-SN),upper central incisor-nasion appoint angle(U1-NA),lower central incisor-nasion B point angle(L1-NB),overbite and coverage,were also assessed.Results:In the 90 children with malocclusion during mixed dentition period after treatment,25 cases(27.78%)were cured,and 56 cases obtained effective treatment(62.22%)and 9 cases(10.00%)did not obtain effective treatment,and effective rate of correction was 90.00%.There was not significant change in SNB angle between before and after treatment,and the difference was not statistically significant(P>0.05).Compared with the indicators before treatment,OP-SN was decreased,while SN-MP,SNA and ANB were all increased after treatment,and the differences were statistically significant(t=6.402,6.135,3.753,50.965,P<0.05).There were not significant changes in Y-axis angle,Wits value,S-Go/N-Me and L1-NB angle between before and after treatment,and the differences were not statistically significant(P>0.05).Compared with the indicators before treatment,the NA-Apo and Go-Pg were increased after treatment,and the differences were statistically significant(t=46.885,7.575,P<0.05).Compared with the indicators before treatment,the NLA,H angle and UL-EP were increased,while LL-EP was decreased after treatment,and the differences were statistically significant(t=2.707,4.163,28.622,3.276,P<0.05).There was not significant change in L1-NB between before and after treatment,and the difference was not statistically significant(P>0.05).Compared with the indicators before treatment,the coverage,U1-SN and U1-NA were increased,while overbite and IMPA were decreased,and the differences were statistically significant(t=16.154,4.723,6.432,4.802,4.106,P<0.05).Conclusion:CBCT can clearly and accurately display three-dimensional morphology and changes of maxillofacial structure of oral cavity,which can provides comprehensive and reliable basis for the assessment for correction effect.Moreover,orthodontic treatment has positive significance in improving dentition occlusion relationship,guiding normal development of jawbone,and optimizing morphology of facial soft tissues,which can provide important reference for the formulation and optimization of the treatment scheme of clinical orthodontics.

Objective:To evaluate corrective effect of cone beam computed tomography(CBCT)in children with malocclusion during mixed dentition period.Methods:A total of 90 children with malocclusion during mixed dentition period who admitted to 3201th hospital between January and December 2023 were enrolled,and all of them underwent routine orthodontics.Before and after treatment,CBCT scan was performed to obtain oral and maxillofacial imaging data.According to measurement and analysis for imaging data,the corrective effect,the relation indicators between sagittal and vertical directions of jawbone,which included the constructed angle among the center point of sella turcica-nasion-superior alveolar seat(SNA),the constructed angle among the center point of sella turcica-nasion-inferior alveolar seat(SNB),the constructed angle among superior alveolar seat-nasion-inferior alveolar seat(ANB),the constructed angle between occlusal plane and sella-nasion plane(OP-SN),the angle between mandibular plane and extended line of occlusal plane(SN-MP),were assessed.In addition,the other related mandibular indicators included the angle(Y axis angle)between Y axis and orbitoauricular plane,the angle of nasion A point line-orbitale-pterygomaxillary fissure line(NA-Apo),gonion-pogonion length(Go-Pg),the distance values(Wits)between anterior nasal crest and orbitomeatal plane,and between posterior nasal crest and orbitomeatal plane also were assessed.Third,the soft tissue-related indicators,which included the distance(UL-EP)between upper lip protrusion point,nasal protrusion point and soft tissue line,and the distance(LL-EP)between lower lip protrusion point,nasal protrusion point and soft tissue line,and the nasal labial angle(NLA),the lower intersection angle between the line connecting the nasal columella point and the infranasal point,and the lower intersection angle between the line connecting the nasal columella point and upper lip protrusion point,and the angle(H)between H line and soft tissue surface angle,were assessed.Finally,the dentally relative indicators,which included incisor mandibular plane angle(IMPA angle),upper central incisor-sella nasion plane angle(U1-SN),upper central incisor-nasion appoint angle(U1-NA),lower central incisor-nasion B point angle(L1-NB),overbite and coverage,were also assessed.Results:In the 90 children with malocclusion during mixed dentition period after treatment,25 cases(27.78%)were cured,and 56 cases obtained effective treatment(62.22%)and 9 cases(10.00%)did not obtain effective treatment,and effective rate of correction was 90.00%.There was not significant change in SNB angle between before and after treatment,and the difference was not statistically significant(P>0.05).Compared with the indicators before treatment,OP-SN was decreased,while SN-MP,SNA and ANB were all increased after treatment,and the differences were statistically significant(t=6.402,6.135,3.753,50.965,P<0.05).There were not significant changes in Y-axis angle,Wits value,S-Go/N-Me and L1-NB angle between before and after treatment,and the differences were not statistically significant(P>0.05).Compared with the indicators before treatment,the NA-Apo and Go-Pg were increased after treatment,and the differences were statistically significant(t=46.885,7.575,P<0.05).Compared with the indicators before treatment,the NLA,H angle and UL-EP were increased,while LL-EP was decreased after treatment,and the differences were statistically significant(t=2.707,4.163,28.622,3.276,P<0.05).There was not significant change in L1-NB between before and after treatment,and the difference was not statistically significant(P>0.05).Compared with the indicators before treatment,the coverage,U1-SN and U1-NA were increased,while overbite and IMPA were decreased,and the differences were statistically significant(t=16.154,4.723,6.432,4.802,4.106,P<0.05).Conclusion:CBCT can clearly and accurately display three-dimensional morphology and changes of maxillofacial structure of oral cavity,which can provides comprehensive and reliable basis for the assessment for correction effect.Moreover,orthodontic treatment has positive significance in improving dentition occlusion relationship,guiding normal development of jawbone,and optimizing morphology of facial soft tissues,which can provide important reference for the formulation and optimization of the treatment scheme of clinical orthodontics.

Colorectal cancer (CRC) seriously threatens people's health and safety, with high incidence and mortality rates. Surgery combined with radiotherapy and chemotherapy is the main treatment method for CRC at present, but the results are unsatisfactory. The emergence of tumor immunotherapy has brought hope to patients with CRC. Immunotherapy based on immune checkpoint inhibitors provides benefits to some patients. In addition, emerging tumor vaccines and adoptive cell therapy have achieved significant results. This paper reviews the current status and progress of immunotherapy for CRC.

Traumatic supraorbital fissure syndrome (TSOFS) is a symptom complex caused by nerve entrapment in the supraorbital fissure after skull base trauma. If the compressed cranial nerve in the supraorbital fissure is not decompressed surgically, ptosis, diplopia and eye movement disorder may exist for a long time and seriously affect the patients′ quality of life. Since its overall incidence is not high, it is not familiarized with the majority of neurosurgeons and some TSOFS may be complicated with skull base vascular injury. If the supraorbital fissure surgery is performed without treatment of vascular injury, it may cause massive hemorrhage, and disability and even life-threatening in severe cases. At present, there is no consensus or guideline on the diagnosis and treatment of TSOFS that can be referred to both domestically and internationally. To improve the understanding of TSOFS among clinical physicians and establish standardized diagnosis and treatment plans, the Skull Base Trauma Group of the Neurorepair Professional Committee of the Chinese Medical Doctor Association, Neurotrauma Group of the Neurosurgery Branch of the Chinese Medical Association, Neurotrauma Group of the Traumatology Branch of the Chinese Medical Association, and Editorial Committee of Chinese Journal of Trauma organized relevant experts to formulate Chinese expert consensus on the diagnosis and treatment of traumatic supraorbital fissure syndrome ( version 2024) based on evidence of evidence-based medicine and clinical experience of diagnosis and treatment. This consensus puts forward 12 recommendations on the diagnosis, classification, treatment, efficacy evaluation and follow-up of TSOFS, aiming to provide references for neurosurgeons from hospitals of all levels to standardize the diagnosis and treatment of TSOFS.

Objective To investigate the predictive value of morphology-voltage-P wave duration(MVP)electrocardiogram(ECG)score for major adverse cardiovascular events(MACE)in elder-ly patients with coronary heart disease(CHD)and atrial fibrillation(AF)within 1 year after treatment.Methods A total of 122 elderly CHD patients with concomitant AF admitted to our department from August 2020 to June 2023 were enrolled,and divided into MACE group(n=31)and non-MACE group(n=91)according to whether MACE occurred within 1 year after treat-ment.Their clinical data,treatment,laboratory indicators and ECG data were collected and ana-lyzed.Multivariate logistic regression analysis was used to identify the risk factors of MACE,and ROC curve was drawn to calculate the AUC value of MVP ECG score in the prediction of MACE occurrence.Results The MACE group had significantly higher Gensini score,C-reactive protein(CRP)level and MVP ECG score,and lower LVEF value than the non-MACE group(P＜0.01).Multivariate logistic regression analysis showed that Gensini score,CRP,LVEF and MVP ECG score were the influencing factors for MACE in elderly CHD patients complicated with AF within 1 year after treatment(OR=4.562,95％CI:1.881-11.064,P=0.001;OR=5.127,95％CI:1.865-14.096,P=0.001;OR=0.998,95％CI:0.687-0.959,P=0.012;OR=4.829,95％CI:2.343-9.953,P=0.001).ROC curve analysis indicated that the AUC value of MVP ECG score in predic-ting MACE within 1 year after treatment in these patients was 0.820,and the optimal cut-off val-ue was 3,the sensitivity was 77.78％and the specificity was 61.00％.Conclusion MVP ECG score has a good predictive value for MACE in elderly CHD patients with concomitant AF within 1 year after treatment.

Objective To explore the correlation of the pan-immune-inflammation value (PIV) and the prognosis of patients with resectable colorectal cancer (CRC) and establish a predictive model. Methods A total of 753 patients who underwent primary lesion resection and were pathologically diagnosed with CRC were enrolled. They were randomly divided into training (n=527) and test (n=226) cohorts. The best cutoff value of PIV was determined by the time-dependent receiver operator characteristics curve, and patients were divided into high- and low-level groups to analyze the relationship between the high- and low-level groups of PIV and the clinicopathological characteristics and survival of patients. Chi-square test, Kaplan-Meier survival analysis, and Cox regression analysis were used to evaluate the prognosis. The accuracy of the model was evaluated by C index and Brier score. Results In the univariate model of overall survival (OS), high (> 231) baseline PIV (HR=1.627; 95%CI: 1.155-2.292, P=0.005) suggested that PIV level might be an independent prognostic factor for OS. The nomogram plotted according to PIV had a C index of 0.823. Its calibration curve showed good agreement between predicted and observed outcomes for one- and three-year OS probabilities, with Brier score of 0.035 and 0.068 for OS, respectively. Conclusion PIV can be used as a prognostic marker in patients with resectable CRC, and a novel prognostic model to guide clinical decision-making in CRC is successfully established.

The condition of patients with severe traumatic brain injury (sTBI) complicated by corona virus 2019 disease (COVID-19) is complex. sTBI can significantly increase the probability of COVID-19 developing into severe or critical stage, while COVID-19 can also increase the surgical risk of sTBI and the severity of postoperative lung lesions. There are many contradictions in the treatment process, which brings difficulties to the clinical treatment of such patients. Up to now, there are few clinical studies and therapeutic norms relevant to sTBI complicated by COVID-19. In order to standardize the clinical treatment of such patients, Critical Care Medicine Branch of China International Exchange and Promotive Association for Medical and Healthcare and Editorial Board of Chinese Journal of Trauma organized relevant experts to formulate the Chinese expert consensus on clinical treatment of adult patients with severe traumatic brain injury complicated by corona virus infection 2019 ( version 2023) based on the joint prevention and control mechanism scheme of the State Council and domestic and foreign literatures on sTBI and COVID-19 in the past 3 years of the international epidemic. Fifteen recommendations focused on emergency treatment, emergency surgery and comprehensive management were put forward to provide a guidance for the diagnosis and treatment of sTBI complicated by COVID-19.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is characterized by diffuse alveolar injury primarily caused by an excessive inflammatory response. Regrettably, the lack of effective pharmacotherapy currently available contributes to the high mortality rate in patients with this condition. Xuebijing (XBJ), a traditional Chinese medicine recognized for its potent anti-inflammatory properties, exhibits promise as a potential therapeutic agent for ALI/ARDS. This study aimed to explore the preventive effects of XBJ on ALI and its underlying mechanism. To this end, we established an LPS-induced ALI model and treated ALI mice with XBJ. Our results demonstrated that pre-treatment with XBJ significantly alleviated lung inflammation and increased the survival rate of ALI mice by 37.5%. Moreover, XBJ substantially suppressed the production of TNF-α, IL-6, and IL-1β in the lung tissue. Subsequently, we performed a network pharmacology analysis and identified identified 109 potential target genes of XBJ that were mainly involved in multiple signaling pathways related to programmed cell death and anti-inflammatory responses. Furthermore, we found that XBJ exerted its inhibitory effect on gasdermin-E-mediated pyroptosis of lung cells by suppressing TNF-α production. Therefore, this study not only establishes the preventive efficacy of XBJ in ALI but also reveals its role in protecting alveolar epithelial cells against gasdermin-E-mediated pyroptosis by reducing TNF-α release.
Animals ; Mice ; Alveolar Epithelial Cells ; Pyroptosis ; Gasdermins ; Lipopolysaccharides/adverse effects* ; Tumor Necrosis Factor-alpha ; Acute Lung Injury/drug therapy* ; Respiratory Distress Syndrome

Objective:The aims of the study were to investigate the relationship among atherogenic index of plasma (AIP) and inflammatory adipocytokines with the severity of coronary artery calcification (CAC) score in coronary artery disease (CAD). And then we analyzed the diagnostic value of the new markers on CAC.Methods:A total of 241 patients with CAD diagnosed by coronary CT angiography (CTA) and coronary angiography in Baoding First Central Hospital from June 2019 to June 2020 were retrospectively enrolled. According to the presence of calcification in coronary CTA, they were divided into CAC group ( n=63) and non-CAC group ( n=178). The clinical data of the patients were collected, and the levels of serum inflammatory factors were measured by enzyme-linked immunosorbent assay (ELISA). The correlation between CAC score and AIP and inflammatory cytokines was analyzed. The diagnostic value of AIP and inflammatory factors in the formation of CAC in patients with CAD. Results:The levels of AIP, serum osteoprotegerin (OPG) and oligomeric matrix protein (COMP) in CAC group were higher than those in non-CAC group, while the levels of serum fibroblast growth factor 21 (FGF21) were lower than those in non-CAC group, with statistically significant difference (all P<0.01). Correlation analysis showed that CAC score of CAD patients was positively correlated with AIP, OPG and COMP ( r=0.581, 0.451, 0.326, P<0.05), and negatively correlated with FGF21 ( r=-0.294, P<0.05). Receiver operating characteristic (ROC) curve analysis showed that AIP, OPG, COMP and FGF21 had diagnostic value for CAC in CAD patients (all P<0.05). AIP>0.387, OPG>5.150 ng/ml, FGF21>136.35 pg/ml, COMP>733.16 ng/ml were independent factors affecting the formation of CAC (all P<0.05). Conclusions:The increase of AIP and the change of inflammatory factors can be used as markers for the diagnosis of CAC formation in CAD patients.

Objective:To evaluate the immunogenicity and immune persistence of purified Vero cells rabies vaccine (PVRV) with Zagreb and Essen regimen.Methods:Prospective study: Patients with first Class II exposure to rabies were recruited from the Dog Injury Cinic of Guangxi Center for Disease Control and Prevention (Guangxi CDC) and randomly divided into the Zagreb (2-1-1) and Essen (1-1-1-1-1) regimen group. All patients were inoculated with the vaccines from the same manufacturer and batch, and 3 ml serum was collected at the 45th day and in 1-year, 2-year and 3-year after immunization. Rapid fluorescent inhibition test (RFFIT) was used to detect rabies virus neutralizing antibody (RVNA). The attenuation of RVNA positive rate and geometric mean titer (GMT) with time was analyzed. Retrospective study: The informed consents for rabies vaccine in the Dog Injury Clinic of Guangxi CDC were checked out. The patients who were injected with PVRV (same manufacturer but unlimited batch) but without passive immune agents for the first time within 3 years were selected and divided into 1-year, 2-year and 3-year group. Each group was further divided into Zagreb and Essen regimen group. The serum (3 ml) was collected at 1 year, 2 years and 3 years after immunization and detected the RVNA by RFFIT.Results:Prospective study: The RVNA positive rates on the 45th day and in 1-year, 2-year and 3-year after immunizationin in the Zagreb and Essen regimen group were 100%, 95%, 85%, 80% and 98.25%, 89.47%, 89.47%, 85.96%, respectively. There was no statistically significant difference in the RVNA positive rates at the same time point between the two regimen groups ( P>0.05). The RVNA GMT on the 45th day and in 1-year, 2-year, and 3-year in the Zagreb and Essen regimen group were 11.32 IU/ml, 1.69 IU/ml, 1.30 IU/ml, 1.30 IU/m and 13.18 IU/ml, 2.13 IU/ml, 1.87 IU/ml, 1.84 IU/m, respectively. There was no significant difference in the RVNA GMT levels at the same time point between the two regimen groups ( F=1.971, P=0.164). The RVNA GMT levels in the two regimen groups had the same trend of attenuation over time (time*group F=0.702, P=0.435). Retrospective study: The RVNA positive rates in 1-year, 2-year and 3-year after immunization in the Zagreb and Essen regimen group were 100%, 95%, 91.43%和94.73%, 86.21%, 87.5%, respectively. There was no statistically significant difference in the RVNA positive rates at the same time point between the two regimen groups ( P>0.05). The RVNA GMT in 1-year, 2-year, and 3-year groups after immunization in the Zagreb and Essen regimen group were 2.65 IU/ml, 2.03 IU/ml, 1.57 IU/ml和3.2 IU/ml, 2.58 IU/ml, 2.45 IU/ml, respectively. There was no significant difference in the RVNA GMT levels at the same time point between the two regimen groups ( P>0.05). Conclusions:The PVRV showed the same excellent immunogenicity and immune persistence after the vaccination with the Zagreb and Essen regimens.