Objective:To explore the therapeutic outcome of consciousness disorders induced by different brain injury mechanisms.Methods:A total of 130 patients with impaired consciousness after brain injuries treated in Nanjing Zijin Hospital from January 2016 to May 2021 were taken as research subjects. According to the causes of injury，they were divided into cerebrovascular accident group（ n = 37），brain trauma group（ n=68），hypoxic-ischemic encephalopathy group（ n = 7），and cerebral aneurysm group（ n = 18）. The patients in the four groups were all given comprehensive treatment，including hyperbaric oxygen（HBO）therapy，electrical stimulation，acupuncture，passive training，and drug therapy. The Glasgow Coma Scale（GCS）scores and China Nanjing persistent vegetative state scale（CNPVSS）scores of the four groups before treatment and after three months of comprehensive treatment combined with HBO were compared，and the consciousness recovery rate and the overall curative effect of the four groups were also compared. Results:After three months of comprehensive treatment combined with HBO，the GCS scores and CNPVSS scores of the four groups were improved compared with those before treatment（all P < 0.05）；the most significant increase of GCS scores and CNPVSS scores was in the cerebral aneurysm group. The highest consciousness recovery rate was in the cerebrovascular accident group（64.86%，24/37），followed by cerebral aneurysm group（55.56%，10/18），and there were statistically significant differences in the consciousness recovery rate among the four groups（ P < 0.01）. The overall effective rate was in the descending order of cerebrovascular accident group［86.49%（32/37）］，cerebral aneurysm group［83.33%（15/18）］，brain trauma group［69.12%（47/68）］，and hypoxic-ischemic encephalopathy group［42.86%（3/7）］，with statistically significant differences（ P < 0.05）. The cerebrovascular accident group and the cerebral aneurysm group achieve higher consciousness recovery rates and greater improvement in consciousness disturbance compared with the other two groups after three months of comprehensive treatment combined with HBO. Conclusion:Different injury mechanisms affect the therapeutic outcomes of consciousness disorders induced by brain injuries.

Objective:To explore the therapeutic outcome of consciousness disorders induced by different brain injury mechanisms.Methods:A total of 130 patients with impaired consciousness after brain injuries treated in Nanjing Zijin Hospital from January 2016 to May 2021 were taken as research subjects. According to the causes of injury，they were divided into cerebrovascular accident group（ n = 37），brain trauma group（ n=68），hypoxic-ischemic encephalopathy group（ n = 7），and cerebral aneurysm group（ n = 18）. The patients in the four groups were all given comprehensive treatment，including hyperbaric oxygen（HBO）therapy，electrical stimulation，acupuncture，passive training，and drug therapy. The Glasgow Coma Scale（GCS）scores and China Nanjing persistent vegetative state scale（CNPVSS）scores of the four groups before treatment and after three months of comprehensive treatment combined with HBO were compared，and the consciousness recovery rate and the overall curative effect of the four groups were also compared. Results:After three months of comprehensive treatment combined with HBO，the GCS scores and CNPVSS scores of the four groups were improved compared with those before treatment（all P < 0.05）；the most significant increase of GCS scores and CNPVSS scores was in the cerebral aneurysm group. The highest consciousness recovery rate was in the cerebrovascular accident group（64.86%，24/37），followed by cerebral aneurysm group（55.56%，10/18），and there were statistically significant differences in the consciousness recovery rate among the four groups（ P < 0.01）. The overall effective rate was in the descending order of cerebrovascular accident group［86.49%（32/37）］，cerebral aneurysm group［83.33%（15/18）］，brain trauma group［69.12%（47/68）］，and hypoxic-ischemic encephalopathy group［42.86%（3/7）］，with statistically significant differences（ P < 0.05）. The cerebrovascular accident group and the cerebral aneurysm group achieve higher consciousness recovery rates and greater improvement in consciousness disturbance compared with the other two groups after three months of comprehensive treatment combined with HBO. Conclusion:Different injury mechanisms affect the therapeutic outcomes of consciousness disorders induced by brain injuries.

Objective To investigate the clinical efficacy of nerve growth factors in the treatment of sudden deafness.Methods A retrospective analysis was performed on 124 cases of hospitalized patients who suffered from unilateral sudden deafness from November 2013 to February 2015.The patients were divided into two groups: 59 in the treatment group and 65 in the control group.Each group was further divided into four subgroups according to different audiometric curves: the low-frequency declining type, the high-frequency declining type, the flat type, the completely deafness type.The control group: the patients were treated with the conventional therapy according to different audiometric curves.The treatment group: intramuscular mouse nerve growth factor treatment was added on the basis of conventional therapy mentioned above.The both treatments lasted 10 days.The total efficiency of two groups was compared ,and the efficiency of the subgroups was also compared.Results The total efficiency of the treatment group was 64.40% and 44.62% for the control group.The total efficiency of the treatment group was significantly higher than the control group.The analysis revealed as having statistically significant differences (x2=4.877,P=0.032<0.05).The total efficiency of the sub-groups by different audiometric curves was further analyzed.All the total efficiency of the sub-groups in treatment group were higher than the sub-groups in the control group, but the results were notconsidered as significantly different(P>0.05).Conclusion The mouse nerve growth factor has a positive effect on the treatment of sudden deafness, and has shown the acceptable clinical efficacy without side-effect.Thus the mouse nerve growth factor is a safe and effective drug for treating sudden deafness.