The pharmaceutical industry faces challenges in quality digitization for complex multi-stage processes, especially in small-sample systems. Here, an intelligent quality prediction and diagnostic (IQPD) framework was developed and applied to Tong Ren Tang's Niuhuang Qingxin Pills, utilizing four years of data collected from four production units, covering the entire process from raw materials to finished products. In this framework, a novel path-enhanced double ensemble quality prediction model (PeDGAT) is proposed, which combines a graph attention network and path information to encode inter-unit long-range and sequential dependencies. Additionally, the double ensemble strategy enhances model stability in small samples. Compared to global traditional models, PeDGAT achieves state-of-the-art results, with an average improvement of 13.18% and 87.67% in prediction accuracy and stability on three indicators. Additionally, a more in-depth diagnostic model leveraging grey correlation analysis and expert knowledge reduces reliance on large samples, offering a panoramic view of attribute relationships across units and improving process transparency. Finally, the IQPD framework integrates into a Human-Cyber-Physical system, enabling faster decision-making and real-time quality adjustments for Tong Ren Tang's Niuhuang Qingxin Pills, a product with annual sales exceeding 100 million CNY. This facilitates the transition from experience-driven to data-driven manufacturing.

Yigongsan， derived from QIAN Yi’s Key to Therapeutics of Children’s Diseases in the Song Dynasty， is a classic pediatric prescription that is included in the Catalogue of Ancient Classic Prescriptions （the Second Batch of Pediatrics） released by the National Administration of Traditional Chinese Medicine in 2022. This paper verifies and analyzes the historical origin， composition， dosage， processing， decoction method and efficacy of Yigongsan by systematically combing ancient books and modern documents. As a result， Yigongsan is composed of five herbs： Panax ginseng， Poria cocos， Atractylodes macrocephala， Citrus reticulata and Glycyrrhiza uralensis， of which P. cocos should be peeled， A. macrocephala is fried with soil， G. uralensis is roasted with honey while P. ginseng and C. reticulata are raw products. According to the dosage of ancient and modern times， each medicinal herb must be ground into fine powder， 1.6 g for each， added with 300 mL of water， 5 pieces of Zingiber officinale， and 2 Ziziphus jujuba， decocted together to 210 mL， and taken before meals. In ancient books， Yigongsan is used to treat vomiting， diarrhea， spleen and stomach deficiency， chest and abdominal distension， and lack of appetite， etc. Modern research showed that Yigongsan could also be used in the diseases of immune system， respiratory system， blood system， etc.， involving infantile anorexia， asthma， anemia， tumors and so on.

Objective:To investigate the efficacy of endoscopic surgery using a chest-breast approach for thyroid papillary cancer and its effect on stress response and pain transmitters.Methods:A total of 100 patients with thyroid papillary cancer who received treatment at Zhoushan Hospital between January 2022 and January 2023 were retrospectively included in this study. These patients were divided into an endoscopic surgery group and a traditional surgery group according to the surgical method used, with 50 patients in each group. The endoscopic surgery group received endoscopic surgery, while the traditional surgery group underwent traditional open surgery. Surgical indicators, postoperative complications, thyroid function measured before surgery and 5 days after surgery, stress response, and pain transmitters were compared between the two groups.Results:The operative time in the endoscopic surgery group was longer than that in the traditional surgery group [(147.84 ± 27.95) minutes vs. (112.31 ± 23.16) minutes, t = 6.92, P < 0.001]. Intraoperative blood loss in the endoscopic surgery group was less than that in the traditional surgery group [(20.81 ± 4.24) mL vs. (37.74 ± 6.56) mL, t = 15.33, P < 0.001]. Postoperative drainage amount in the endoscopic surgery group was significantly less than that in the traditional surgery group [(32.34 ± 6.84) mL vs. (47.96 ± 12.31) mL, t = 7.84, P < 0.001]. Postoperative length of hospital stay in the endoscopic surgery group was significantly shorter than that in the traditional surgery group [(4.06 ± 1.31) days vs. (6.87 ± 1.54) days, t = 9.83, P < 0.001). The incidence of postoperative complications in the endoscopic surgery group was significantly lower than that in the traditional surgery group (6.00% vs 20.00%, χ2 = 4.33, P = 0.037). At 5 days post-surgery, the levels of triiodothyronine and thyroxine in the endoscopic surgery group were significantly lower than those in the traditional surgery group, while the level of thyroid stimulating hormone was significantly higher ( t = 5.57, 8.69, 10.17, all P < 0.001). At 5 days post-surgery, the levels of cortisol and malondialdehyde in the endoscopic surgery group were significantly lower than those in the traditional surgery group ( t = 9.31, 17.21, both P < 0.001). At 5 days post-surgery, the levels of substance P, neuropeptide Y, and prostaglandin E 2 in the endoscopic surgery group were significantly lower than those in the traditional surgery group ( t = 9.84, 13.65, 10.94, all P < 0.05). Conclusion:The endoscopic surgery using a chest-breast approach is highly effective in treating thyroid papillary cancer, with minimal complications. It greatly enhances thyroid function, elicits a low stress response, and effectively suppresses the release of pain transmitters.

At present,traditional Chinese medicine(TCM) has attracted more and more attention from the international community.The demand for TCM is increasing in the world.The hidden dangers of potential quality and safety of TCM are also becoming increasingly prominent.Aflatoxin contamination has become one of the important factors affecting the safety of Chinese herbal medicines,and it will fundamentally affect human health and life safety.A variety of methods are used to reduce aflatoxins,however,there are few suitable methods that can be widely used in the cost-effective and large-scale promotion of Chinese herbal medicines.Therefore,it is of great significance to continue to study measures to solve the pollution problems of Aspergillus flavus and its toxins.This article summarizes the hazards and contamination status of aflatoxin,the prevention and control of the growth of A. flavus, and the measures for reducing aflatoxin,and looks ahead to the future prevention and control of A. flavus and its toxins,aiming at providing ideas for the pollution problem of A. flavus and its toxin,to ensure the quality of Chinese herbal medicines,so as to ensure clinical safety medication.

Objective To investigate the impact of chemotherapy plus fluoxetine on depression and quality of life of tumor patients.Methods 160 cases cancer patients were randomly divided into the control group and the experimental group with 80 cases in each group.The control group received routine chemotherapy,while the experimental group adopted fluoxetine based on routine chemotherapy.The incidence of depression and improvement of life quality were compared between two groups.Results The incidence of depression was lower,and proportion of patients with good quality of life was higher in the experimental group compared with those of the control group.Conclusions To take chemotherapy plus fluoxetine has certain values in decrease depression and improve quality of life.

To meet the demands of managing international academic conferences on Biomedical Engineering, a management system was designed and implemented based on Internet. The system was aimed to implement the cooperation of different departments to manage common affair and academic papers of the conference together. In addition, it could be connected to the membership management system of Chinese Society of Biomedical Engineering. With its advanced, practical, humanized and expansible characteristics, the system performed seven main functions, including the management in general information, participant information, papers, reviewer information, booking, exhibition and manager information. The system proved to be feasible and optimized as well in the 7th Asia-Pacific Conference on Medical and Biological Engineering.
Biomedical Engineering ; Computer Communication Networks ; Congresses as Topic ; organization & administration ; Humans ; Information Services ; International Cooperation ; Internet