Objective:To examine the effect of social support on benefit finding in patients with advanced gastrointestinal cancer and the mediating role of spirituality in this relationship, providing insights for promoting psychological well-being in gastrointestinal cancer patients.Methods:A convenience sampling method was used to select 300 inpatients with advanced gastrointestinal cancer admitted to the Department of Integrated Traditional Chinese Medicine, Sun Yat-sen University Cancer Center, from February 2022 to December 2023. Patients were surveyed using the General Information Questionnaire, Benefit Finding Scale (BFS), Perceived Social Support Scale (PSSS), and Spiritual Attitude and Involvement List (SAIL). Pearson correlation analysis was used to assess correlations between social support, spirituality, and benefit finding. Mediation analysis was conducted using model 4 in the PROCESS macro in SPSS 24.0.Results:A total of 300 questionnaires were distributed, with 295 valid responses (effective response rate of 98.33%). The mean scores for BFS, PSSS, and SAIL among 295 patients were (72.62±6.30), (62.31±10.41), and (100.17±17.34), respectively. Both social support and spirituality were positively correlated with benefit finding ( r=0.540 and 0.529, P<0.05), and social support was positively correlated with spirituality ( r=0.611, P<0.05). Social support positively predicted benefit finding directly, and the mediating effect of spirituality between social support and benefit finding was 0.194, accounting for 35.79% of the total effect. Conclusions:Providing strong social support while fostering patients' spirituality can significantly enhance their benefit finding.

Objective:To examine the effect of social support on benefit finding in patients with advanced gastrointestinal cancer and the mediating role of spirituality in this relationship, providing insights for promoting psychological well-being in gastrointestinal cancer patients.Methods:A convenience sampling method was used to select 300 inpatients with advanced gastrointestinal cancer admitted to the Department of Integrated Traditional Chinese Medicine, Sun Yat-sen University Cancer Center, from February 2022 to December 2023. Patients were surveyed using the General Information Questionnaire, Benefit Finding Scale (BFS), Perceived Social Support Scale (PSSS), and Spiritual Attitude and Involvement List (SAIL). Pearson correlation analysis was used to assess correlations between social support, spirituality, and benefit finding. Mediation analysis was conducted using model 4 in the PROCESS macro in SPSS 24.0.Results:A total of 300 questionnaires were distributed, with 295 valid responses (effective response rate of 98.33%). The mean scores for BFS, PSSS, and SAIL among 295 patients were (72.62±6.30), (62.31±10.41), and (100.17±17.34), respectively. Both social support and spirituality were positively correlated with benefit finding ( r=0.540 and 0.529, P<0.05), and social support was positively correlated with spirituality ( r=0.611, P<0.05). Social support positively predicted benefit finding directly, and the mediating effect of spirituality between social support and benefit finding was 0.194, accounting for 35.79% of the total effect. Conclusions:Providing strong social support while fostering patients' spirituality can significantly enhance their benefit finding.

OBJECTIVE: The population density and diversity of Sinomenium acutum (Menispermaceae) have been greatly reduced recently by overharvesting for medicinal purposes in China. Therefore, it is urgent that the remaining populations are investigated, and that strategies for the utilization and conservation of this species are developed. This study aimed to find the possible glacial refugia and define the genetic diversity of S. acutum for its proper utilization and conservation. METHODS: A total of 77 S. acutum samples were collected from four locations, Qinling Mountains, Daba Mountains, Dalou Mountains, and Xuefeng Mountains, in subtropical China. Genetic diversity among and between these populations were phylogenetically analyzed using four chloroplast DNA molecular markers (atpI-atpH, trnQ-5'rps16, trnH-psbA and trnL-trnF). RESULTS: A total of 14 haplotypes (C1 to C14) were found in collected samples. Haplotypes C1 and C3 were shared among all populations, with C3 as the ancestral haplotype. Haplotypes C11 and C12 diverged the most from C3 and other haplotypes. No obvious phylogeographic structure was found in four locations using the GST/NST test. There is no evidence of rapid demographic expansion in S. acutum based on the mismatch distribution, and the results of Tajima's D test, and Fu's FS test. Our analyses of molecular variance revealed a high level of genetic variation within populations. In contrast, the genetic differentiation among S. acutum populations was low, indicating frequent gene flow. CONCLUSION Xuefeng, Dalou, and Daba Mountains were possible glacial refugia for the populations of S. acutum. C1, C3, C11 and C12 haplotypes of S. acutum should be carefully preserved and managed for their genetic value.

Intestinal injury is a common adverse reaction of clinical chemotherapy drugs, which limits the further application of chemotherapy drugs and causes serious physical and mental burden to patients. At present, the mechanism of chemotherapy-induced intestinal injury is complex, and traditional Chinese medicine has an excellent preventive effect. This article reviews the related mechanisms of intestinal flora imbalance, oxidative stress, inflammatory response, cell apoptosis, and immune damage caused by chemotherapy, and summarizes the role of traditional Chinese medicine in prevention and treatment of oxidative stress, inflammatory response, cell apoptosis, and immune damage.

Transdermal drug delivery is an administration route which can avoid the first-pass effect,maintain steady plasma concentrations and enhance bioavailability. Drug transporting through the skin by passage through the stratum corneum leads to the viable epidermis and the dermis.With the development of the computer technology,many mathematical models for predic-ting the absorption of drugs have been built according to physical and chemical properties of drugs and physiological characteristics of each skin layer.This article presented provides a summary of the progress of mathematical models for predicting percutaneous absorption of drugs.