Body weight abnormalities, including overweight, obesity, and underweight, have become a dual public health challenge in Chinese adults: overweight and obesity lead to a variety of chronic complications, while underweight increases the risks of malnutrition, sarcopenia, and organ dysfunction. To systematically address these issues, multidisciplinary experts in endocrinology, sports science, nutrition, and psychiatry from various regions have held multiple weight management seminars. Based on the latest epidemiological data and clinical evidence, they expanded the guideline to include assessment and intervention strategies for underweight, in addition to the core content of obesity management. This guideline outlines the etiological mechanisms, evaluation methods, and multidimensional management strategies for overweight and obesity, covering key areas such as diagnosis and assessment, medical nutrition therapy, exercise prescription, pharmacological intervention, and psychological support. It is intended to provide a scientific and standardized approach to weight management across the adult population, aiming to curb the rising prevalence of obesity, mitigate complications associated with abnormal body weight, and improve nutritional status and overall quality of life.

Objective:To explore the application effect of Kaitianmen point massage on pain, faligue, anxiety and depression in patients with rheumatoid arthritis.Methods:This study was a randomized controlled study, a total of 80 patients with rheumatoid arthritis who were admitted to Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine from May to November 2023 were selected as the research objects. The control group was given routine treatment and nursing, and the experimental group was given Kaitianmen acupoint massage on the basis of routine treatment and nursing. The differences in pain score, fatigue score, anxiety and depression score before and after intervention were compared between the two groups.Results:In the final, there were 37 cases in the experimental group and 36 cases in the control group completed the study. Before intervention, there was no statistically significant difference in pain scores, fatigue scores, anxiety and depression scores between the two groups (all P>0.05). After four weeks of intervention, the pain score of the experimental group was (2.06 ± 0.35), and that of the control group was (3.72 ± 0.59), the difference was statistically significant ( t=14.57, P<0.05). After four weeks of intervention, the fatigue score of the experimental group was (20.11 ± 8.03), and that of the control group was (25.02 ± 8.32), the difference was statistically significant ( t=2.55, P<0.05). After four weeks of intervention, the anxiety score of the experimental group was (48.33 ± 6.13), which was significantly different from (53.99 ± 4.91) of the control group ( t=4.35, P<0.05), and the depression score of the experimental group was (49.99 ± 6.33), compared with the (54.86 ± 4.83) of control group, the difference was statistically significant ( t=3.69, P<0.05). Conclusions:Kaitianmen acupoint massage can relieve limb pain, fatigue, anxiety and depression in patients with rheumatoid arthritis, which is worthy of clinical promotion.

Objective:To explore the application effect of Kaitianmen point massage on pain, faligue, anxiety and depression in patients with rheumatoid arthritis.Methods:This study was a randomized controlled study, a total of 80 patients with rheumatoid arthritis who were admitted to Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine from May to November 2023 were selected as the research objects. The control group was given routine treatment and nursing, and the experimental group was given Kaitianmen acupoint massage on the basis of routine treatment and nursing. The differences in pain score, fatigue score, anxiety and depression score before and after intervention were compared between the two groups.Results:In the final, there were 37 cases in the experimental group and 36 cases in the control group completed the study. Before intervention, there was no statistically significant difference in pain scores, fatigue scores, anxiety and depression scores between the two groups (all P>0.05). After four weeks of intervention, the pain score of the experimental group was (2.06 ± 0.35), and that of the control group was (3.72 ± 0.59), the difference was statistically significant ( t=14.57, P<0.05). After four weeks of intervention, the fatigue score of the experimental group was (20.11 ± 8.03), and that of the control group was (25.02 ± 8.32), the difference was statistically significant ( t=2.55, P<0.05). After four weeks of intervention, the anxiety score of the experimental group was (48.33 ± 6.13), which was significantly different from (53.99 ± 4.91) of the control group ( t=4.35, P<0.05), and the depression score of the experimental group was (49.99 ± 6.33), compared with the (54.86 ± 4.83) of control group, the difference was statistically significant ( t=3.69, P<0.05). Conclusions:Kaitianmen acupoint massage can relieve limb pain, fatigue, anxiety and depression in patients with rheumatoid arthritis, which is worthy of clinical promotion.

Body weight abnormalities, including overweight, obesity, and underweight, have become a dual public health challenge in Chinese adults: overweight and obesity lead to a variety of chronic complications, while underweight increases the risks of malnutrition, sarcopenia, and organ dysfunction. To systematically address these issues, multidisciplinary experts in endocrinology, sports science, nutrition, and psychiatry from various regions have held multiple weight management seminars. Based on the latest epidemiological data and clinical evidence, they expanded the guideline to include assessment and intervention strategies for underweight, in addition to the core content of obesity management. This guideline outlines the etiological mechanisms, evaluation methods, and multidimensional management strategies for overweight and obesity, covering key areas such as diagnosis and assessment, medical nutrition therapy, exercise prescription, pharmacological intervention, and psychological support. It is intended to provide a scientific and standardized approach to weight management across the adult population, aiming to curb the rising prevalence of obesity, mitigate complications associated with abnormal body weight, and improve nutritional status and overall quality of life.

Objective　To assess the diagnostic efficacy of the cell-free Mycobacterium tuberculosis DNA testing (CF-TB) in tuberculous pleurisy. Methods　A total of 71 patients diagnosed with tuberculous pleurisy and 35 patients with non-tuberculous pleurisy were selected from the Fifth People's Hospital of Wuxi between January to December 2022. The standard pleural puncture was conducted to collect pleural effusion, which was then utilized for Mycobacterium tuberculosis culture, GeneXpert Mycobacterium tuberculosis/rifampicin resistance (GeneXpert MTB/RIF), CF-TB, and adenosine deaminase (ADA) testing. Blood samples were subjected to tuberculosis infection T-cell spotting test (T-SPOT.TB) assay. The receiver operator characteristic curve (ROC) was applied to obtain the optimal cut-off value for pleural fluid CF-TB and to compare the diagnostic performance of CF-TB with other methods. Data analysis was conducted using SPSS 22.0 software, with statistical significance defined as P<0.05. Results　The ROC curve analysis determined that the optimal cycle threshold (Ct) value for diagnosing tuberculous pleurisy using CF-TB in pleural fluid was 38.489, with a sensitivity of 91.5% and specificity of 97.1%. In comparison, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of T-SPOT.TB and pleural fluid ADA in diagnosing tuberculous pleurisy were 86.0%, 71.4%, 86.0%, 71.4%, 81.1%, and 55.0%, 91.4%, 92.9%, 50.8%, 67.0%, respectively, all of which were lower than the diagnostic efficiency of CF-TB. Furthermore, the specificity of pleural fluid CF-TB in diagnosing tuberculous pleurisy (97.1%) was not significantly different from GeneXpert MTB/RIF (100%) and Mycobacterium tuberculosis culture (100%), but its sensitivity (91.5%) was significantly higher than both GeneXpert MTB/RIF (19.7%) and Mycobacterium tuberculosis culture (28.2%), with a statistically significant difference (P<0.001). Conclusions　Compared to the conventional gold standard for diagnosing tuberculous pleurisy, CF-TB exhibits a higher sensitivity and its specificity is superior to that of tuberculosis immunological test. Consequently, CF-TB can serve as a valuable complement to other traditional detection methods in aiding the diagnosis of tuberculous pleurisy.

Adipose derived mesenchymal stromal cells (ADSC) are pluripotent stem cells isolated from adipose tissue and have great application potential in regenerative medicine for their rich sources of derivation, relatively less trauma when sampling and few ethical problems. ADSC have preferable immunomodulatory capacity, and can regulate the immunologic functions of dendritic cells, macrophages, NK cells, NKT cells, B lymphocytes and T lymphocytes. In order to better understand the role of ADSC in immunoregulation, this paper systematically reviewed the immunomodulatory effects of ADSC on several representative immune cells.

ObjectiveTo investigate the clinical efficacy of vastus medialisoblique enhancement plus electroacupuncture intervention in treating patellar chondromalacia.MethodFifty-two patients meeting the inclusion criteria were randomly allocated to a treatment group of 32 cases and a control group of 20 cases. The treatmentgroup received vastus medialis oblique enhancement plus electroacupuncture intervention and the control group, electroacupuncture intervention alone. Both groups were treated once daily, 10 times as a course, for four consecutive courses. The Visual Analogue Scale (VAS) score was counted in the two groups before and after treatment. The clinical therapeutic effects were evaluated in the two groups.ResultThe VAS score improved significantly in both groups of patients after treatment compared with before(P<0.05). It improved significantly more in the treatment group than in the control group (P<0.05). The cure rate and the total efficacy rate were 37.5% and 96.9%, respectively, in the treatment group, which were higher than a cure rate of 20.0% and a total efficacy rate of 75.0% in the control group, respectively. ConclusionVastus medialis oblique enhancement plus electroacupuncture intervention can improve the clinical symptom of pain more markedly and heighten the clinical therapeutic effect in patients with patellar chondromalacia. Its effect is better than that of electroacupuncture intervention alone.

Objective To observe whether pressure boost could induce changes in intracardiac pressures,and also to investigate the mechanism involved.Methods Seventeen healthy volunteers [13 males and 4 females,with an age range of 25.76 ± 5.16 years,and average age of 18-34] were recruited for the study.Without the knowledge of the examiners and examinees about the purpose of the research,they entered the hyperbaric chamber.The examiners detect the intraocular pressures (IOP) of the examinees with the Japanese NIDEK NT-2000 non-contact tonometer under the following conditions:(1) baseline intraocular pressures at rest.(2) during the stay at atmospheric pressure for 30 min without breathing pure oxygen; after breathing pure oxygen for 10 min at atmospheric pressure.(3) compression to a pressure of 60 kPa at a rate of 2.0 kPa/s without breathing pure oxygen; (4) during the stay at the pressure of 60 kPa for 30 min without breathing pure oxygen ; (5) after decompression to 0 kPa pressure,also without breathing pure oxygen.Results Average intraocular pressures measured during their stay at atmospheric pressure for 30 min without breathing pure oxygen,after breathing pure oxygen for 10 min at atmospheric pressure and after decompression to 0 kPa pressure without breathing pure oxygen were (13.57 ±3.04),(13.86 ± 3.16) and (13.33 ± 3.12) mmHg respectively.No statistical significance could be seen in measured data,as compared with that of the baseline intraocular pressures [(13.48 ± 2.87) mmHg] (P ＞ 0.05).Average intraocular pressures measured after they were compressed to 60 kPa without breathing pure oxygen and during their stay at 60 kPa for 30 min without breathing pure oxygen were (16.06 ±2.48) and (15.65 ± 2.54) mmHg respectively,and statistical difference could be seen,when compared with that of the baseline intraocular pressures(P ＞ 0.01).Conclusions When there was a pressure boost,most people would display elevated IOP due to poor response to pressure,only a few people would experience IOP drop also due to poor response to pressure and IOP of still a few people would remain basically unchanged.

Objective To observe whether pressure boost could induce changes in intracardiac pressures,and also to investigate the mechanism involved.Methods Seventeen healthy volunteers [13 males and 4 females,with an age range of 25.76 ± 5.16 years,and average age of 18-34] were recruited for the study.Without the knowledge of the examiners and examinees about the purpose of the research,they entered the hyperbaric chamber.The examiners detect the intraocular pressures (IOP) of the examinees with the Japanese NIDEK NT-2000 non-contact tonometer under the following conditions:(1) baseline intraocular pressures at rest.(2) during the stay at atmospheric pressure for 30 min without breathing pure oxygen; after breathing pure oxygen for 10 min at atmospheric pressure.(3) compression to a pressure of 60 kPa at a rate of 2.0 kPa/s without breathing pure oxygen; (4) during the stay at the pressure of 60 kPa for 30 min without breathing pure oxygen ; (5) after decompression to 0 kPa pressure,also without breathing pure oxygen.Results Average intraocular pressures measured during their stay at atmospheric pressure for 30 min without breathing pure oxygen,after breathing pure oxygen for 10 min at atmospheric pressure and after decompression to 0 kPa pressure without breathing pure oxygen were (13.57 ±3.04),(13.86 ± 3.16) and (13.33 ± 3.12) mmHg respectively.No statistical significance could be seen in measured data,as compared with that of the baseline intraocular pressures [(13.48 ± 2.87) mmHg] (P ＞ 0.05).Average intraocular pressures measured after they were compressed to 60 kPa without breathing pure oxygen and during their stay at 60 kPa for 30 min without breathing pure oxygen were (16.06 ±2.48) and (15.65 ± 2.54) mmHg respectively,and statistical difference could be seen,when compared with that of the baseline intraocular pressures(P ＞ 0.01).Conclusions When there was a pressure boost,most people would display elevated IOP due to poor response to pressure,only a few people would experience IOP drop also due to poor response to pressure and IOP of still a few people would remain basically unchanged.