In recent years,natural antimicrobial biomaterials have received widespread attention due to their rich sources,broad anti-microbial spectrum,high antimicrobial activity,good biocompatibility,etc.They play an important role in caries prevention and treat-ment by inhibiting the formation of biofilm and removing the formed biofilm.In this paper,we summarize the inhibitory effects of differ-ent natural antimicrobial biomaterials on Streptococcus mutans,the main caries-causing organism,and its biofilm,with a view to provi-ding theoretical references for caries prevention and treatment.

In recent years,natural antimicrobial biomaterials have received widespread attention due to their rich sources,broad anti-microbial spectrum,high antimicrobial activity,good biocompatibility,etc.They play an important role in caries prevention and treat-ment by inhibiting the formation of biofilm and removing the formed biofilm.In this paper,we summarize the inhibitory effects of differ-ent natural antimicrobial biomaterials on Streptococcus mutans,the main caries-causing organism,and its biofilm,with a view to provi-ding theoretical references for caries prevention and treatment.

Objective To investigate the clinical effect of lithium disilicate glass ceramic cantilever resin-bonded fixed partial dentures(CRBFPDs)on single anterior tooth loss to provide a reference for the selection of restoration methods for single anterior tooth loss.Methods This study was reviewed and approved by the Ethics Committee,and informed consent was obtained from the patients.Forty-two patients with less than two anterior teeth with monomaxillary loss were included in this study.After 6 months,1 year,2 years,and 3 years,the aesthetic and functional effects of the restorations and the periodontal health status were evaluated,and the visual analog scale(VAS)was used to assess pa-tient satisfaction.Results During the observation period,the connector fractured in one case within 3 months.One case had debonded within 2 years.The aesthetic restoration effect of all lithium disilicate glass ceramic CRBFPDs was categorized as Class A.The periodontal health was good,there was no clinical absorption in the soft and hard tissues of the abutment or subbridge,periodontal status according to the evaluation indices was classified as class A,and the total satisfaction rate of the patient was 100%.Conclusion For single anterior tooth loss patients,lithium disilicate glass ceramic cantilever resin-bonded fixed partial denture can achieve the restoration effect of less invasion,better adhesion,aesthetics,comfort and good biocompatibility.With high patient satisfaction,it can be considered an ideal restoration method for replacing a single anterior tooth.