Joint diseases have traditionally been linked to cartilage degeneration and inflammation,often ne-glecting the vital role of the joint barrier.This review introduces the novel concept of the"joint barrier"as an essential ana-tomical and functional unit in maintaining joint homeostasis.We systematically elucidate its structural components and functional characteristics,underscoring how dysfunction of the joint barrier contributes to the pathogenesis of various joint diseases.This perspective provides fresh insights into disease mechanisms and potential therapeutic targets.We highlight cutting-edge findings on the molecular regulatory mechanisms underlying joint barrier imbalance,focusing on epigenetic modifications,metabolic reprogramming,and intercellular communication networks.These discoveries establish a new framework for understanding joint pathology and identifying innovative intervention strategies.Additionally,we propose forward-thinking research directions with significant translational potential,including exploring the association between im-mune components and synovial barrier function,developing novel drugs targeting the barrier microenvironment,and inves-tigating the regulatory mechanisms of joint barrier imbalance influenced by systemic factors.These strategies promise to revolutionize the diagnosis,treatment,and prevention of joint diseases.By integrating the latest research and proposing fu-ture directions,this review offers a comprehensive understanding of joint barrier disorders and their implications for joint diseases,paving the way for new therapeutic approaches and concepts in the field.

Joint diseases have traditionally been linked to cartilage degeneration and inflammation,often ne-glecting the vital role of the joint barrier.This review introduces the novel concept of the"joint barrier"as an essential ana-tomical and functional unit in maintaining joint homeostasis.We systematically elucidate its structural components and functional characteristics,underscoring how dysfunction of the joint barrier contributes to the pathogenesis of various joint diseases.This perspective provides fresh insights into disease mechanisms and potential therapeutic targets.We highlight cutting-edge findings on the molecular regulatory mechanisms underlying joint barrier imbalance,focusing on epigenetic modifications,metabolic reprogramming,and intercellular communication networks.These discoveries establish a new framework for understanding joint pathology and identifying innovative intervention strategies.Additionally,we propose forward-thinking research directions with significant translational potential,including exploring the association between im-mune components and synovial barrier function,developing novel drugs targeting the barrier microenvironment,and inves-tigating the regulatory mechanisms of joint barrier imbalance influenced by systemic factors.These strategies promise to revolutionize the diagnosis,treatment,and prevention of joint diseases.By integrating the latest research and proposing fu-ture directions,this review offers a comprehensive understanding of joint barrier disorders and their implications for joint diseases,paving the way for new therapeutic approaches and concepts in the field.

Objective To evaluate the effect of treatment for unstable intertrochanteric fractures of the aged with LCP.Methods 51 patients with intertrochanteric fracture were included.24 cases were operated with LCP while 27 cases with DHS.Clinical assessments included operation details,complications and follow-up interviews were analyzed.Results Compared with DHS,operation with LCP has advantages of simple operation,short operation time (min)(68.7 ±17.2 vs 89.9 ±15.1 ,P ＜0.01),minor wound,less blood during(ml)(286.7 ±130.1 vs 416.3 ±177.0,P＜0.01)and after the operation(ml)(50.7 ±25.1 vs84.6 ±30.1,P＜0.01).higher reliability and fewer complications.Conclusion LCP is one of the ideal choices for the treatment of unstable in-tertrochanteric fractures of the aged.