Objectives:To analyze and compare the clinical efficacy of traditional titanium mesh and three-dimensional(3D)printed artificial vertebral bodies in anterior cervical corpectomy and fusion(ACCF).Methods:A retrospective analysis was conducted on 42 patients with cervical spondylotic myelopathy who underwent single segment ACCF at our hospital from January 2015 to January 2024.The patients were divid-ed into a traditional titanium mesh group(n=22,9 males and 13 females,aged 60.6±10.0 years)and a 3D printed artificial vertebral body group(n=20,10 males and 10 females,aged 55.5±8.3 years)based on the type of implant.There was no statistical difference between the two groups in age,gender,body mass index(BMI),as well as affected segments(P＞0.05).The operative time,intraoperative blood loss,and length of hos-pital stay,as well as imaging parameters(C2-7 Cobb angle),neurological function[Japanese Orthopaedic Associ-ation(JOA)score and Nurick grading],neck pain visual analogue scale(VAS)score,and neck disability index(NDI)before operation,at postoperative 3d and 1 year were recoreded and compared between the two groups,meanwhile,the postoperative cage deposition and other complications were also analyzed and compared.Re-sults:There was no significant difference in the operative time between the two groups of cases(P＞0.05).The intraoperative blood loss and postoperative length of hospital stay of the 3D printed artificial vertebral body group were significantly lower than those in the traditional titanium mesh group(P＜0.05).At each postoperative time point,both groups showed significant improvement in JOA scores,Nurick grading,VAS scores,and NDI scores compared to preoperative levels.However,there were no significant differences in JOA scores,Nurick grading,VAS scores,and NDI scores between the two groups of patients at preoperation,postoperative 3d,and postoperative 1 year.According to radiological measurement analysis,both groups of patients showed great improvement in the C2-7 Cobb angle after surgery,and 3D printed artificial vertebral body group was better than traditional titanium mesh group in C2-7 Cobb angle on postoperative 3d(20.2°±10.1° vs 13.8°±9.8°,P＜0.05)and at 1 year follow-up(19.7°±10.2° vs 13.0°±9.7°,P＜0.05).There was one case of cage settlement in the traditional titanium mesh group,while no cage settlement was found in the 3D printed artificial vertebral body group during follow-up.Conclusions:Both traditional titanium mesh and 3D printed artificial vertebral body in ACCF can effectively treat cervical spondylotic myelopathy and significantly improve patients' symptoms.However,the application of 3D printed artificial vertebral bodies can significantly reduce intraoperative bleeding and postoperative hospitalization days for patients.Moreover,3D printed artificial vertebral bodies have more advantages in maintaining the physiological structure of the cervical spine.

Objectives:To analyze and compare the clinical efficacy of traditional titanium mesh and three-dimensional(3D)printed artificial vertebral bodies in anterior cervical corpectomy and fusion(ACCF).Methods:A retrospective analysis was conducted on 42 patients with cervical spondylotic myelopathy who underwent single segment ACCF at our hospital from January 2015 to January 2024.The patients were divid-ed into a traditional titanium mesh group(n=22,9 males and 13 females,aged 60.6±10.0 years)and a 3D printed artificial vertebral body group(n=20,10 males and 10 females,aged 55.5±8.3 years)based on the type of implant.There was no statistical difference between the two groups in age,gender,body mass index(BMI),as well as affected segments(P＞0.05).The operative time,intraoperative blood loss,and length of hos-pital stay,as well as imaging parameters(C2-7 Cobb angle),neurological function[Japanese Orthopaedic Associ-ation(JOA)score and Nurick grading],neck pain visual analogue scale(VAS)score,and neck disability index(NDI)before operation,at postoperative 3d and 1 year were recoreded and compared between the two groups,meanwhile,the postoperative cage deposition and other complications were also analyzed and compared.Re-sults:There was no significant difference in the operative time between the two groups of cases(P＞0.05).The intraoperative blood loss and postoperative length of hospital stay of the 3D printed artificial vertebral body group were significantly lower than those in the traditional titanium mesh group(P＜0.05).At each postoperative time point,both groups showed significant improvement in JOA scores,Nurick grading,VAS scores,and NDI scores compared to preoperative levels.However,there were no significant differences in JOA scores,Nurick grading,VAS scores,and NDI scores between the two groups of patients at preoperation,postoperative 3d,and postoperative 1 year.According to radiological measurement analysis,both groups of patients showed great improvement in the C2-7 Cobb angle after surgery,and 3D printed artificial vertebral body group was better than traditional titanium mesh group in C2-7 Cobb angle on postoperative 3d(20.2°±10.1° vs 13.8°±9.8°,P＜0.05)and at 1 year follow-up(19.7°±10.2° vs 13.0°±9.7°,P＜0.05).There was one case of cage settlement in the traditional titanium mesh group,while no cage settlement was found in the 3D printed artificial vertebral body group during follow-up.Conclusions:Both traditional titanium mesh and 3D printed artificial vertebral body in ACCF can effectively treat cervical spondylotic myelopathy and significantly improve patients' symptoms.However,the application of 3D printed artificial vertebral bodies can significantly reduce intraoperative bleeding and postoperative hospitalization days for patients.Moreover,3D printed artificial vertebral bodies have more advantages in maintaining the physiological structure of the cervical spine.

ObjectiveAn HPLC method was established for the determination of azelaic acid and potassium azeloycinate diglycinate in cosmetics. MethodsThe samples were extracted with 60 mmol·L^-1 sodium hydroxide water solution-methyl alcohol. After centrifugation and filtration， the analysis of azelaic acid and potassium azeloycinate diglycinate was performed with a SVEA C8（250 mm×4.6 mm， 5 μm） column， using 15 mmol‧L^-1 potassium dihydrogen phosphate solution （pH=3.0） and acetonitrile for gradient elution at a flow rate of 1.0 mL·min^-1.The analytes were detected with UV detector， and quantified by external standard curve. ResultsThe results showed a good linearity in the range of 5‒1 000 μg‧mL^-1 with correlation coefficients （r） larger than 0.999. The detection limit of azelaic acid and potassium azeloycinate diglycinate （LOD） was 0.020% and 0.015%， respectively. The spiked recoveries were 87.66% to 108.96% with the relative standard deviation （RSD） of 0.6% to 3.3%. ConclusionThe method is simple， rapid and highly sensitive. It is suitable for the determination of azelaic acid and potassium azeloycinate diglycinate in cosmetics.

Objective Toevaluatetheclinicalvalueofmagneticresonanceenterography (MRE)indiagnosingCrohn’sdisease (CD).Methods ThearticlesconcerningthediagnosisofCD byusing MRE weresystematicallysearchedindatabasesincluding PubMed,EMbase,CochraneLibrary,WebofScience,CNKI,CBM,WanFangandVIPdata.Tworeviewersindependentlyscreenedliterature, extracteddata,andassessedbiasriskofincludedstudiesbyusingtheQUADAS-2.Then,thisMeta-analysiswasperformedbyusing Stata12.0software.Thepooledweightedsensitivity,specificity,positivelikelihoodratio(PLR),negativelikelihoodratio (NLR)and diagnosticoddsratio(DOR)werecalculated,thesummaryreceiveroperatingcharacteristiccurve(sROC)wasdrawnandtheAUC wascalculated.Results Atotalof16studieswereincluded,involving1276patientsand919bowelsegments.TheresultsofMeta-analysisshowed that,thepooledsensitivity,specificity,PLR,NLR,DORandAUCofMREdiagnosingCDwere0.87(95%CI:0.79,0.92),0.92(95%CI:0.89, 0.94),10.6(95%CI:7.4,15.2),0.15(95%CI:0.09,0.24),72.69(95%CI:32.7,161.51),0.95(95%CI:0.93,0.97),respectively.Theresultsof subgroupanalysissuggestedthat,thestudytype,MRT-field,pathogenicsiteanddiagnosticcriteriaplayedlittleeffectonthevalueof MREdiagnosingCD (P>0.05).Conclusion MREhadhigheraccuracyfordiagnosingCDand mayservedasanefficientimaging methodfordiagnosingCD.

Lung cancer is a malignant tumor,leading to the highest morbidity and mortality worldwide.Non-small cell lung cancer (NSCLC)accounts for approximately 80% of all lung cancer types.Out of all the patients with advanced NSCLC,more than 40% develop brain metastasis,and lung cancer associated with brain metastasis indicates poor prognosis.Traditional treatment options,such as ra-diotherapy,chemotherapy and surgery,have an extremely limited role in improvement of prognosis of such patients.In recent years, with the development of stereotactic radiotherapy and targeted therapy,particularly chemotherapy combined with targeted therapy, radiotherapy combined with targeted therapy and other types of therapies,NSCLC patients with brain metastases could benefit from these therapies with an improved quality of life and prolonged median overall survival. However, the ideal treatment regimen for NSCLC patients with brain metastases remains controversial.Recent advances in NSCLC with brain metastases will be described elabo-rately in this paper,to provide a theoretical basis for selecting a reasonable treatment plan for non-small lung cancer patients with brain metastasis.

BACKGROUND:There is a high morbidity after spinal cord injury, and the therapeutic strategy is limited to early surgical intervention, medication and post-treatment exercise that only can improve the motor function slightly. However, there is no effective cure method. OBJECTIVE:To study the effect of partition-type spinal cord catheter combined with bone marrow stromal stem cels on T8 spinal cord transection damage in rats. METHODS:Fifty rats were randomized into five groups (n=10 per group): group I, T8 spinal cord transection (5 mm) was made in rats with no treatment; group II, the partition-type tube was inserted into the injured site after modeling; group III, partition-type tube combined with bone marrow stromal stem cels was implanted into the injured site after modeling; group IV, partition-type tube combined with polyglycolic acid fibers was implanted into the injured site after modeling; group V, partition-type tube combined with bone marrow stromal stem cels and polyglycolic acid fibers was implanted into the injured site after modeling. RESULTS AND CONCLUSION:At 2 and 12 weeks postoperatively, Basso, Beattie and Bresnahan scores were significantly higher in the groups III and IV than the groups I, II, IV (P < 0.05). At 12 weeks postoperatively, the latency of motor evoked potential below the injury plane was significantly decreased in group V compared with groups I, II, III, IV (P < 0.05). Immunohistochemical results displayed that in the groups III and V, regenerated nerve fibers grew positively and arranged orderly among the tubes, and there was no obvious winding phenomenon. Under transmission electron microscopy, a certain number of myelinated nerve fibers were found as bridges among groups. These findings indicate that the partition-type chitosan tube combined with bone marrow stromal stem cels has a good connection with the injured spinal cord a good connection to restore part of electrophysiological properties, accelerate the axon regeneration, recover the motor function, thereby providing a new direction for the treatment of spinal cord injury. Cite this article:Zhao XW, Liu X, Yu DP, Rong H, Yu XS, Yang CS, Liu T, Zhao TB. Partition-type spinal cord catheter combined with bone marrow stromal stem cels in the repair of spinal cord transection injury in rats. Zhongguo Zuzhi Gongcheng Yanjiu. 2016;20(1):42-48.

Objective To survey the current situation of hypertension among "three minority ethnic groups" in Inner Mongolia Autonomous Region.Methods Hypertension epidemiological survey among Three Minority Ethnic Groups and Han nationality aged ≥ 18 years was performed from June to December 2010.Results The prevalence rate of hypertension among the surveyed population was 29.4％ (630/2 146) (standardized prevalence was 34.6％).The prevalence rate of hypertension in male was 33.8％ (359/1 062) (standardized prevalence was 39.9％),and the prevalence rate in female was 25.0％ (271/1 084) (standardized prevalence was 26.6％),and the prevalence rate in male was higher than in female (P ＜ 0.01).The prevalence rate of hypertension for the Oroqen nationality,Ewenki nationality and Daur nationality was 33.8％ (92/272),32.4％ (170/524),and 30.2％ (174/576) respectively (standardized prevalence was 33.7％,33.1％,and 3 1.3％),and which was significantly higher than in the Han nationality (25.1％ (194/774),P ＜ 0.01) (standardized prevalence was 25.8％).The awareness,treatment and control rate of hypertension in the Oroqen nationality residents was 64.1％ (59/92),56.5％ (52/92),27.2％ (25/92) (standardized rate was 63.5％,56.8％ and 27.4％),and 60.0％ (102/170),53.5％ (91/170),24.1％ (41/170) (standardized rate was 62.9％,56.7％,26.6％) in the Ewenki nationality residents,and 59.2％ (103/174),54.0％ (94/174),20.7％ (36/174) (standardized rate was 60.3％,54.7％,21.4％) in the Daur nationality residents,and 65.0％ (126/194),57.7％ (112/194),27.3％ (53/194) (standardized rate was 63.3％,56.5％,27.1％) in the Han nationality residents.Awareness rate,treatment rate and control rate were similar among different nationalities (all P ＞ 0.05).Conclusion The prevalence rate of hypertension among " three minority ethnic groups" residents in Inner Mongolia Autonomous Region is high and comprehensive prevention and therapy strategies are warranted to reduce the hypertension burden in these residents.

OBJECTIVETo investigate the microsurgical tchniques and effects for the resection of anterior clinoid meningioma (ACM).

METHODSBetween January 2003 and March 2013, a total of 46 ACM patients were operated on via the pterion approach or lateral subfrontal approach. There were 16 male patients and 30 female patients, their mean age was 48.5 (16-69) years. Symptoms lasted from 1 month to 9 years(average 24.7 months). Preoperative CT and MRI examination showed that the tumors were located in the anterior clinoid process (25 cases on the right side, 21 cases on the left side). The average maximal tumor diameter was 4.4 cm (1.9-7.4 cm). The patients were peroidly followed-up on outpatient on 3 months to 6 months, then every year postoperativelly. The clinical data, radiological findings, surgical records and outcome of patients were retrospectively analyzed, and the prognostic factors were ananlyzed by using of the unpaired data χ(2) test with continuity correction.

RESULTSOf fourty-six patients operated on, apparently complete removal was achieved in 36 patients (78.3%), 10 patients (21.7%) had minimal residual tumors, 5 of which had gamma knife radiosurgery. Preexisting visual deficit improved in 21 of 41 patients (51.2%), unchanged in 16(35.6%), and worsened in 9(20.0%). At 3-6 months after discharge, 37(80.4%) patients had a good recovery, 7(15.6%) patients were moderately disabled, 1(2.2%) presented with severe disability, and 1 (2.2%) patient died of surgery-related causes. The tumor wrapping blood vessels (χ(2) = 4.676, P = 0.031) and violating cavernous sinus(χ(2) = 4.973, P = 0.026) were causes of unfavorable prognosis. During the mean follow-up of 35.1 months (range, 4-107 months) for 40 patients, the average Karnofsky score was 83.2. Tumor recurred in 4 cases: 2 of which required reoperation, and 2 had gamma knife radiosurgery.

CONCLUSIONSTumor wrapped vessels and invasion of the cavernous sinus are important unfavorable prognostic factors for ACM resection. By using appropriate surgical strategies and techniques, ACM can be removed safely via the pterion approach or lateral subfrontal approach with relatively low morbidity and mortality.

Adolescent ; Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Male ; Meningeal Neoplasms ; surgery ; Meningioma ; surgery ; Microsurgery ; Middle Aged ; Neurosurgical Procedures ; methods ; Retrospective Studies ; Treatment Outcome ; Young Adult

BACKGROUND:Usual y, amount of bleeding during replacement and drainage amount after replacement were recorded to evaluate the amount of bleeding in patients with arthroplasty. These are dominant blood loss. Studies demonstrated that recessive blood loss exceeded 50%of total amount. OBJECTIVE:To compare the blood loss during total knee arthroplasty under high negative pressure drainage and common negative pressure drainage and to assess the effect of high negative pressure drainage on hidden blood loss in total knee arthroplasty.
METHODS:A total of 60 patients undergoing lateral total knee arthroplasty were equal y divided into high negative pressure drainage group and conventional drainage group (control group). We calculated the total blood loss (dominant blood loss and hidden blood loss) and blood transfusion amount with the Gross equation. The recovery after surgery and complications were compared.
RESULTS AND CONCLUSION:In high negative pressure drainage group, the total blood loss was (646±184) mL and the hidden blood loss was (215±128) mL. In the control group, the total blood loss was (867±296) mL and the hidden blood loss was (457±268) mL. The total blood loss and hidden blood loss in the high negative pressure drainage group were significantly less than those in the control group (P<0.05). The average blood transfusion amount was 224 mL in the high negative pressure drainage group and 467 mL in the control group. Fol owing unilateral total knee arthroplasty, total blood loss, hidden blood loss and blood transfusion amount after arthroplasty were less in the high negative pressure drainage group than those in the control group. In particular, the decrease in hidden blood loss was helpful to observe and treat the pathogenetic condition and to avoid potential risk, and benefits the recovery of knee joint function after surgery.

Background and objective At present no standard second-line combination has been established for recurrent small cell lung cancer (SCLC). hTerefore we evaluate the effcacy and safety of irinotecan in combination with nedapla-tin/cisplatin against refractory or relapsed small cell lung cancer. Methods In this retrospective study, we analyzed the data of 1,140 patients who diagnosed small cell lung cancer at our hospital from April 2009 to April 2012. Of all the patients, 34 patients were treated with irinotecan and nedaplatin (irinotecan 60 mg/m2 on days 1, 8 nedaplatin 85 mg/m2 day 1, every 3 weeks) , and 20 patients were treated with irinotecan and cisplatin (irinotecan 60 mg/m2 on days 1, 8 cisplatin 75 mg/m2 day 1, every 3 weeks) as the second-line treatment. Prognostic factors of overall survival (OS) were estimated by Kaplan-Meier and Cox's Regression-proportional hazards model. Results Of all the 54 eligible patients, median progression free survival (PFS) was 4.9 months, and median OS was 13.3 months. Median PFS was 5.4 months for irinotecan plus nedaplatin (IN) and 4.9 months for irinotecan plus cisplatin (IC), respectively (P=0.465). Median OS was 14.3 months and 13.3 months, respectively (P=0.704). In multivariate analysis, ECOG PS, number of metastases and cycles of chemotherapy were independent prognostic factors. hTe toxicities were mild, while toxicity proifle was slightly different for each of the arms:hematologic toxicity was higher in IN group, and diarrhea was higher in IC group. Conclusion Irinotecan plus platinum is effective and tolerable for refractory and relapsed small cell lung cancer. Irinotecan plus nedaplatin is non-inferior to irinotecan plus cisplatin in terms of effcacy and safety.