Objective:To explore the diagnostic value of high-frequency ultrasound and mobile digital X-ray in neonatal necrotizing enterocolitis(NEC)and the consistency in staging of NEC,in order to provide reference for early clinical diagnosis and targeted intervention measures.Methods:The clinical data of 84 suspected NEC neonates(with abdominal distension,vomiting,bloody stool,etc.)who were treated in our hospital from Mar 2023 to Mar 2024 were retrospectively analyzed.After admission,they were all examined by high-frequency ultrasound and mobile digital X-ray,and the clinical comprehensive diagnosis(combining clinical symptoms,laboratory indicators,surgical pathology)results were used as the"gold standard"to compare the diagnostic results and efficacy of high-frequency ultrasound and mobile digital X-ray examinations alone and in combination for NEC.The consistency between the diagnostic results of the two methods for different stages of NEC and the clinical comprehensive diagnosis results was analyzed using Kappa value.Results:The comprehensive clinical diagnosis results showed that among 84 suspected NEC neonates,56 were positive and 28 were negative.Among the 56 cases of NEC,20 cases were in stageⅠ,25 cases in stageⅡ,and 11 cases in stage Ⅲ.The results of mobile digital X-ray examination showed that 43 were positive and 41 were negative.The results of high-frequency ultrasound examination showed that 45 were positive and 39 were negative.The results of high-frequency ultrasound combined with mobile digital X-ray diagnosis showed that 55 were positive and 29 were negative.The sensitivity and accuracy of high-frequency ultrasound combined with mobile digital X-ray examination for NEC diagnosis were higher than those of high-frequency ultrasound examination or mobile digital X-ray examination alone(P＜0.05).Moreover,the missed diagnosis rate of the combined detection was lower(P＜0.05).The results of mobile digital X-ray diagnosis showed that there were 17 cases in stageⅠ,16 cases in stage Ⅱ,and 10 cases in stage Ⅲ.The consistency Kappa value with the comprehensive clinical diagnosis results was 0.618(P＜0.01).The results of high-frequency ultrasound diagnosis showed that there were 17 cases in stage Ⅰ,18 cases in stage Ⅱ,and 10 cases in stage Ⅲ.The consistency Kappa value was 0.701(P＜0.01).The results of high-frequency ultrasound combined with mobile digital X-ray diagnosis showed that there were 20 cases in stage Ⅰ,23 cases in stage Ⅱ,and 12 cases in stage Ⅲ.The consistency Kappa value was 0.886(P＜0.01).Conclusion:High-frequency ultrasound combined with mobile digital X-ray can improve the diagnostic accuracy of NEC,and can be used clinically to assess the stage of NEC early,providing a reference for early clinical evaluation and diagnosis,as well as targeted intervention treatment plans.

Objective:To investigate disease characteristics of patients with psoriatic arthritis (PsA) based on the PsA cohort in West China Hospital, so as to provide a reference for clinicians in its diagnosis, treatment, and evaluation strategy formulation.Methods:A cross-sectional study was carried out, and a descriptive analysis was conducted on clinical data from PsA patients who were treated at the Department of Dermatology, West China Hospital, Sichuan University between April 2, 2020, and January 21, 2025. Demographic characteristics, clinical manifestations, laboratory and imaging findings, and treatment modalities were analyzed.Results:A total of 530 PsA patients were included, of whom 332 (62.6%) were males and 198 (37.4%) were females, with ages of 44.1 ± 12.4 years. Skin lesions preceded joint symptoms in 452 patients (85.3%), with time intervals ( M [ Q1, Q3]) of 8.0 (3.0, 15.0) years. Overweight or obesity was observed in 319 patients (60.2%), and 188 (35.5%) had comorbid fatty liver. Peripheral joint involvement was common (485 cases, 91.5%), with the proximal interphalangeal joints being most frequently affected by tenderness (172 cases, 35.5%) and swelling (119 cases, 24.5%) ; the number of enthesitis cases identified by ultrasonography (116 cases, 23.9%) was significantly higher than that by clinical examination (82 cases, 15.5%) ; axial joint involvement was observed in 258 patients (48.7%), with the sacroiliac joints most commonly affected (201 cases, 77.9%). Regarding treatment, conventional systemic drugs were predominant in the treatment of psoriasis prior to the diagnosis of PsA; after the diagnosis of PsA, the number of patients receiving targeted therapies increased to 334 (63.0%), with interleukin-17 inhibitors being the most common (140 cases, 26.4%), followed by tumor necrosis factor-α inhibitors (106 cases, 20.0%) and Janus kinase inhibitors (39 cases, 7.4%) . Conclusions:PsA predominantly affects males over 40 years old and is characterized by preceding skin lesions, delayed diagnosis, and multiple comorbidities. High-frequency ultrasound has advantages in the early detection of peripheral enthesitis. Further attention is needed for managing comorbidities such as fatty liver and obesity-related metabolic conditions.

Objective·To investigate the efficacy and safety of a dose-reduced,all-oral lenalidomide/melphalan/prednisone acetate(RMP)regimen in elderly and frail patients with newly diagnosed multiple myeloma(NDMM).Methods·Elderly and frail NDMM patients who visited the Department of Hematology of Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,and the Third People's Hospital of Kunshan from April 2018 to March 2024 were retrospectively included.Clinical data and laboratory indicators were collected,and all patients were treated with the RMP regimen.SPSS 27.0 and R software were used for statistical analysis.Independent t-test was applied to normally distributed quantitative data,Mann-Whitney U test to non-normally distributed quantitative data,and x2 test and Fisher's exact probability method to qualitative data.Kaplan-Meier survival curves and Log-rank test were used for survival analysis.Results·Among the 22 elderly and frail NDMM patients treated with RMP,the median age was 76.3(68.4,95.0)years,and the median follow-up time was 25.5 months.The overall response rate(ORR)was 68.2%,and the rate of≥very good partial response(VGPR)was 36.4%.The median progression-free survival(PFS)was 20.53 months.The median PFS in the≤75-year-old group was 25.23(95%CI 12.95?37.52)months,while in the>75-year-old group it was 18.23(95%CI 14.86?21.61)months.There was no significant difference between the two groups.The median PFS in the≥partial response(PR)group was 20.67(95%CI 13.57?27.76)months,and in the

Objective·To investigate the efficacy and safety of a dose-reduced,all-oral lenalidomide/melphalan/prednisone acetate(RMP)regimen in elderly and frail patients with newly diagnosed multiple myeloma(NDMM).Methods·Elderly and frail NDMM patients who visited the Department of Hematology of Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,and the Third People's Hospital of Kunshan from April 2018 to March 2024 were retrospectively included.Clinical data and laboratory indicators were collected,and all patients were treated with the RMP regimen.SPSS 27.0 and R software were used for statistical analysis.Independent t-test was applied to normally distributed quantitative data,Mann-Whitney U test to non-normally distributed quantitative data,and x2 test and Fisher's exact probability method to qualitative data.Kaplan-Meier survival curves and Log-rank test were used for survival analysis.Results·Among the 22 elderly and frail NDMM patients treated with RMP,the median age was 76.3(68.4,95.0)years,and the median follow-up time was 25.5 months.The overall response rate(ORR)was 68.2%,and the rate of≥very good partial response(VGPR)was 36.4%.The median progression-free survival(PFS)was 20.53 months.The median PFS in the≤75-year-old group was 25.23(95%CI 12.95?37.52)months,while in the>75-year-old group it was 18.23(95%CI 14.86?21.61)months.There was no significant difference between the two groups.The median PFS in the≥partial response(PR)group was 20.67(95%CI 13.57?27.76)months,and in the

Objective:To explore the diagnostic value of high-frequency ultrasound and mobile digital X-ray in neonatal necrotizing enterocolitis(NEC)and the consistency in staging of NEC,in order to provide reference for early clinical diagnosis and targeted intervention measures.Methods:The clinical data of 84 suspected NEC neonates(with abdominal distension,vomiting,bloody stool,etc.)who were treated in our hospital from Mar 2023 to Mar 2024 were retrospectively analyzed.After admission,they were all examined by high-frequency ultrasound and mobile digital X-ray,and the clinical comprehensive diagnosis(combining clinical symptoms,laboratory indicators,surgical pathology)results were used as the"gold standard"to compare the diagnostic results and efficacy of high-frequency ultrasound and mobile digital X-ray examinations alone and in combination for NEC.The consistency between the diagnostic results of the two methods for different stages of NEC and the clinical comprehensive diagnosis results was analyzed using Kappa value.Results:The comprehensive clinical diagnosis results showed that among 84 suspected NEC neonates,56 were positive and 28 were negative.Among the 56 cases of NEC,20 cases were in stageⅠ,25 cases in stageⅡ,and 11 cases in stage Ⅲ.The results of mobile digital X-ray examination showed that 43 were positive and 41 were negative.The results of high-frequency ultrasound examination showed that 45 were positive and 39 were negative.The results of high-frequency ultrasound combined with mobile digital X-ray diagnosis showed that 55 were positive and 29 were negative.The sensitivity and accuracy of high-frequency ultrasound combined with mobile digital X-ray examination for NEC diagnosis were higher than those of high-frequency ultrasound examination or mobile digital X-ray examination alone(P＜0.05).Moreover,the missed diagnosis rate of the combined detection was lower(P＜0.05).The results of mobile digital X-ray diagnosis showed that there were 17 cases in stageⅠ,16 cases in stage Ⅱ,and 10 cases in stage Ⅲ.The consistency Kappa value with the comprehensive clinical diagnosis results was 0.618(P＜0.01).The results of high-frequency ultrasound diagnosis showed that there were 17 cases in stage Ⅰ,18 cases in stage Ⅱ,and 10 cases in stage Ⅲ.The consistency Kappa value was 0.701(P＜0.01).The results of high-frequency ultrasound combined with mobile digital X-ray diagnosis showed that there were 20 cases in stage Ⅰ,23 cases in stage Ⅱ,and 12 cases in stage Ⅲ.The consistency Kappa value was 0.886(P＜0.01).Conclusion:High-frequency ultrasound combined with mobile digital X-ray can improve the diagnostic accuracy of NEC,and can be used clinically to assess the stage of NEC early,providing a reference for early clinical evaluation and diagnosis,as well as targeted intervention treatment plans.

Objective:To investigate disease characteristics of patients with psoriatic arthritis (PsA) based on the PsA cohort in West China Hospital, so as to provide a reference for clinicians in its diagnosis, treatment, and evaluation strategy formulation.Methods:A cross-sectional study was carried out, and a descriptive analysis was conducted on clinical data from PsA patients who were treated at the Department of Dermatology, West China Hospital, Sichuan University between April 2, 2020, and January 21, 2025. Demographic characteristics, clinical manifestations, laboratory and imaging findings, and treatment modalities were analyzed.Results:A total of 530 PsA patients were included, of whom 332 (62.6%) were males and 198 (37.4%) were females, with ages of 44.1 ± 12.4 years. Skin lesions preceded joint symptoms in 452 patients (85.3%), with time intervals ( M [ Q1, Q3]) of 8.0 (3.0, 15.0) years. Overweight or obesity was observed in 319 patients (60.2%), and 188 (35.5%) had comorbid fatty liver. Peripheral joint involvement was common (485 cases, 91.5%), with the proximal interphalangeal joints being most frequently affected by tenderness (172 cases, 35.5%) and swelling (119 cases, 24.5%) ; the number of enthesitis cases identified by ultrasonography (116 cases, 23.9%) was significantly higher than that by clinical examination (82 cases, 15.5%) ; axial joint involvement was observed in 258 patients (48.7%), with the sacroiliac joints most commonly affected (201 cases, 77.9%). Regarding treatment, conventional systemic drugs were predominant in the treatment of psoriasis prior to the diagnosis of PsA; after the diagnosis of PsA, the number of patients receiving targeted therapies increased to 334 (63.0%), with interleukin-17 inhibitors being the most common (140 cases, 26.4%), followed by tumor necrosis factor-α inhibitors (106 cases, 20.0%) and Janus kinase inhibitors (39 cases, 7.4%) . Conclusions:PsA predominantly affects males over 40 years old and is characterized by preceding skin lesions, delayed diagnosis, and multiple comorbidities. High-frequency ultrasound has advantages in the early detection of peripheral enthesitis. Further attention is needed for managing comorbidities such as fatty liver and obesity-related metabolic conditions.

As a receptor protein,GPR120 is activated by long-chain fatty acids(such as omega-3 fat-ty acids,alpha-linolenic acid,eicosapentaenoic acid,and docosahexaenoic acid.It plays an important regulatory role in gastrointestinal peptide release,inflammation,lipogenesis,glucose tolerance,and insulin sensitivity.In order to study the synergistic regulation of the GPR120 gene on milk fat me-tabolism and its anti-inflammatory effects in dairy cow MAC-T cells,the GPR120 activator TUG-891 and the inhibitor AH7614 were used to treat both dairy cow MAC-T cells and LTA-induced inflammatory dairy cow MAC-T cells.This treatment aimed to detect the expression of key genes involved in milk fat synthesis and inflammatory factors.The results showed that the GPR120 gene activator significantly increased the relative expression levels of cholesterol regulatory element binding protein(SREBP1)and fatty acid synthase(FASN),key genes for milk fat synthesis.Addi-tionally,the expression levels of the inflammatory factor interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were reduced in the inflammatory dairy cow MAC-T cell model,which prelimi-natively reveals that GPR120 co-regulates milk fat and mammary inflammation in dairy cows,thereby laying a foundation for subsequent molecular mechanism research.

OBJECTIVE To observe the short-term efficacy and safety of venetoclax combined with homoharringtonine and cytarabine in the treatment of acute myeloid leukemia （AML）. METHODS The data of 40 newly diagnosed AML patients admitted to our hospital from October 2022 to November 2023 were retrospectively collected and divided into observation group and control group according to treatment plan， with 20 cases in each group. The patients in the control group were given Daunorubicin hydrochloride for injection+Cytarabine for injection， and the patients in the observation group were given Venetoclax tablets+ Homoharringtonine injection+Cytarabine for injection. The patients in both groups were given relevant medicine， with 28 days as one cycle. The short-term efficacy， negative rate of minimal residual disease （MRD）， duration of granulocyte deficiency， duration of platelet （PLT） ＜20×109 L－1， transfusion volume of suspended red blood cells and platelet， and the occurrence of adverse drug reactions were evaluated in both groups after 1 cycle of induction chemotherapy. RESULTS The complete remission or complete remission with incomplete hematologic recovery （CR/CRi） rate in the observation group was significantly higher than control group （P＜0.05）， and the negative rate of MRD in the observation group was also significantly higher than control group （P＜0.05）. However， in low-， medium- and high-risk patients， there was no statistical significance in CR/CRi rates between the two groups （P＞0.05）. There were no significant differences in the duration of agranulocytosis， the duration of PLT ＜20×109 L－1， the amount of suspended red blood cell transfusion， the amount of platelet transfusion， the incidence of hematologic toxicity and the incidence of non-hematologic toxicity between 2 groups （P＞0.05）. CONCLUSIONS Venetoclax combined with homoharringtonine and cytarabine show good short-term efficacy and safety in the treatment of AML.

Objective To investigate the correlation between bone mineral density(BMD)at different hip positions with muscle parameters and physical performance in middle-aged and elderly people in Kunming area.Methods 531 middle-aged and elderly volunteers were recruited from the Radiology Department of the First People's Hospital of Yunnan Province from May 2021 to April 2022.All study subjects completed the five-times-sit-to-stand test(FTSST)and hip quantitative CT(QCT)examinations.Volunteers'total hip(TH),femoral neck(FN),and intertrochanteric(IT)BMD were measured by using QCT PRO workstation and using OsiriX software to measure the area and density of their gluteus maximus muscle,gluteus medius,and minimus muscle and midthigh muscle.Divide male and female volunteers into positive and negative groups respectively based on FTSST time≥12 seconds or<12 seconds,and analyze the differences in hip BMD between the groups;Also divide male and female volunteers into three groups(50～59 years old,60～69 years old,70 years old and above)at the age of 10,and analyze the correlation between hip BMD and muscle parameters in different age and gender stratification.Control for age and BMI,and then perform partial correlation analysis on the above indicators.Results The BMD of the hip in the female FTSST positive group was lower than that in the negative group(P<0.001),while there was no statistically significant difference between the male groups(P>0.05).After adjusting for age and BMI,among males,FN BMD was positively correlated with gluteus medius and minimus muscle density in the age groups of 50～59 and 60～69(P<0.05),while TH BMD,FN BMD,and IT BMD were strongly positively correlated with gluteus medius and minimus muscle density in the age group over 70(P<0.05).For females,the correlation between hip BMD and muscle density in the age groups of 50～59 and 60～69 was weak,while BMD in all parts of the hip was not correlated with muscle density in the age group over 70(P>0.05).There was a negative correlation between TH BMD,FN BMD,and gluteus medius and minimus muscle area in the age group of 50～59 years old for males(P<0.05),while there was a significant negative correlation between TH BMD,IT BMD,and gluteus maximus area in the age group of 70 years old and above for females(P<0.05).Conclusion The BMD of various parts of the hip in the female FTSST positive group is lower than that in the negative group.The density of the gluteus medius and minimus muscle can to some extent serve as a predictive indicator of femoral neck bone strength in middle-aged and elderly men in Kunming area.