Objective To compare the safety and efficacy of oral sulfate solution(OSS)and compound polyethylene glycol(PEG)for intestinal preparation before colonoscopy.Methods A retrospective analysis was conducted on 2,000 patients who underwent intestinal preparation before colonoscopy using OSS and PEG from September 2023 to September 2024.According to different intestinal preparation drugs,the patients were divided into the OSS group(1 000 cases,oral OSS)and the PEG group(1 000 cases,oral 4 L PEG).The intestinal cleanliness,cleaning effect,intestinal cavity bubbles,positive rate of colonoscopy and incidence of adverse reactions were compared between the two groups of patients.Results The evaluation results of cleaning effect showed that the success rate of intestinal preparation was 92.5%(925/1 000)in the OSS group and 91.7%(917/1 000)in the PEG group,with no statistical significance between the two groups(P>0.05).The results of Boston bowel preparation scale(BBPS)score showed that there was no statistical significance between the two groups in left colon score(P>0.05),but the total score,middle and right colon score in OSS group were higher than those in PEG group,with statistical significance(P<0.05).The results of intestinal bubble evaluation showed that the satisfaction rate of bubble evaluation in OSS group(96.2%)was higher than that in PEG group(90.3%),the difference was statistically significant(P<0.05).There was no significant difference in the positive rate of colonoscopy and the incidence of adverse events between the two groups(P>0.05).Conclusion OSS has a good defoaming effect in intestinal preparation,and its cleaning effect is comparable to that of PEG,with high safety.

Objective To compare the safety and efficacy of oral sulfate solution(OSS)and compound polyethylene glycol(PEG)for intestinal preparation before colonoscopy.Methods A retrospective analysis was conducted on 2,000 patients who underwent intestinal preparation before colonoscopy using OSS and PEG from September 2023 to September 2024.According to different intestinal preparation drugs,the patients were divided into the OSS group(1 000 cases,oral OSS)and the PEG group(1 000 cases,oral 4 L PEG).The intestinal cleanliness,cleaning effect,intestinal cavity bubbles,positive rate of colonoscopy and incidence of adverse reactions were compared between the two groups of patients.Results The evaluation results of cleaning effect showed that the success rate of intestinal preparation was 92.5%(925/1 000)in the OSS group and 91.7%(917/1 000)in the PEG group,with no statistical significance between the two groups(P>0.05).The results of Boston bowel preparation scale(BBPS)score showed that there was no statistical significance between the two groups in left colon score(P>0.05),but the total score,middle and right colon score in OSS group were higher than those in PEG group,with statistical significance(P<0.05).The results of intestinal bubble evaluation showed that the satisfaction rate of bubble evaluation in OSS group(96.2%)was higher than that in PEG group(90.3%),the difference was statistically significant(P<0.05).There was no significant difference in the positive rate of colonoscopy and the incidence of adverse events between the two groups(P>0.05).Conclusion OSS has a good defoaming effect in intestinal preparation,and its cleaning effect is comparable to that of PEG,with high safety.

Objective:To summarize experience of nursing in radiofrequency ablation (RFA) for adrenocortical adenoma with Cushing′s syndrome combined steroid-induced diabetes mellitus.Methods:The key of preoperative nursing was precise glucose control by using insulin pump. Focus on patients psychological intervention. It was important for closely monitor the change of blood pressure, cortisol levels and biochemical index to prevent acute complications such as adrenal crisis during RFA. Pay attention to postoperative nutrition management for reduce blood glucose fluctuation and adverse reactions of hydrocortisone at postoperative.Results:No severe complications occurred during this procedure. After twenty-day nursing and treatment, the patient′s blood glucose control was stable, and the symptoms related to Cushing′s syndrome gradually disappeared.Conclusion:The ultrasound guided radiofrequency ablation in adrenocortical adenoma with Cushing′s syndrome combined with steroid-induced diabetes mellitus was a feasible, safe, and minimally invasive treatment. The key to effectively reduce postoperative complications and ensure the success of the operation. Are adequate preoperative preparation and strict monitor.

Objective To explore the effect of community family nursing intervention on glycemic control of type 2 diabetic patients. Methods Ninety-two patients with type 2 diabetes after discharge in 6 communities of Tianhe District in Guangzhou were divided into a study group and a control group , 46 cases in each . The control group received routine care , while patients in the study group received additional community family nursing intervention, including personalized health education, diabetes family day and sharing, telephone follow-up and family home visits. The fasting plasma glucose, 2h-postprandial glucose and glycosylated hemoglobin A1c were compared. Results There were no significant differences in fasting plasma glucose, 2h-postprandial glucose and glycosylated hemoglobin A1c (all P>0.05). After intervention, there were significant differences in the three eridoxes between the two groups(all P<0.05). Conclusion The community family nursing intervention is of great importance to control the blood glucose, improve the therapeutic compliance and self-management ability in patients with type 2 diabetes.

Objective:To explore the influence on inflammation cytokines for anti-IL-1βand TNF-αIgY intranasal treatment in guinea pigs with allergic rhinitis.Methods:The allergic rhinitis model in guinea pigs was established using ovalbumin(OVA).Hartley guinea pigs were randomly divided into the control group(group C,n=17),the allergic rhinitis model group(group M,n=27),the 0.1%anti-IL-1βand TNF-αIgY treatment group(group Z1,n=21)and the fluticasone propionate treatment group(group Z2,n=21). At 2 h,4 h and 8 h after the last treatment,blood was got by heart puncture,as well as nose was lavaged using 0.9% saline and the nasal lavage fluid( NLF) was collected.The level of cytokines was examined using ELISA kits.Results: In the peripheral blood, the levels of IL-1β,IL-5,IL-9,IL-13,IL-18,IL-33 and TGF-β1 from 2 h to 8 h;TNF-αand OVA-specific IgE from 2 h to 4 h;and IL-22 from 4 h to 8 h were significantly decreased in the 0.1%anti-IL-1βand TNF-αIgY treatment group compared with the allergic rhinitis model group(P<0.05).In the NLF,the levels of IL-1β,IL-5,IL-9,IL-13,IL-22,IL-33,TNF-α,TGF-β1 and OVA-specific IgE from 2 h to 8 h;and IL-18 at 2 h were significantly decreased in the 0.1% anti-IL-1βand TNF-αIgY treatment group compared with the allergic rhinitis model group ( P<0.05 ) .Conclusion: Anti-IL-1βand TNF-αIgY intranasal treatment can significantly reduce inflammation cytokine levels in allergic rhinitis guinea pigs.

Objective:To investigate therapeutic mechanism of immunoglobulin Yolk (IgY) against tumour necrosis factor alpha ( TNF-α) and interleukin-1 beta ( IL-1β) in guinea pigs with allergic rhinitis.Methods: Hartley guinea pigs were randomly divided into the control group (group C,n=17),the allergic rhinitis model group (group M,n=27),the 0.1%anti-TNF-αand IL-1βIgY treating group (group Z1,n=21) and the fluticasone propionate treating group (group Z2,n=21).The allergic rhinitis model in guinea pigs was established using ovalbumin.After treatment for 2 h,4 h,8 h,nose and bronchial lung were lavaged using 0.9%saline, the nasal lavage fluid (NLF) and bronchoalveolar lavage fluid (BALF) were collected,the precipitated cells were stained using Wright′s,the nasal mucosa and lung tissues were stained using methylene blue and eosin (HE),and TNF-α,IL-1β,IL-5 and IL-33 in nasal mucosa and lung tissues were stained using immunohistochemistry.Results:There were a large amount of eosinophils and more serious inflammation responses in nasal mucosa in the M group compared with the Z 1 and Z2 groups.In the lung tissues,there were more alveolar tube damage ,pulmonary interstitial edema ,interval thickening ,thickening of bronchial smooth muscle and inflammation cell in-filtration in the M group compared with the Z 1 and Z2 groups.The eosinophils ,lymphocytes and neutrophils were significantly decreased in NLF and BALF in the Z1 and Z2 groups compared with the M group (P<0.05).The expressions of IL-1βand TNF-αfrom 2 h to 8 h and IL-5 and IL-33 from 4 h to 8 h significantly decreased in the nasal mucosa and lung tissues in the Z 1 group compared with the M group ( P<0.05 ).Conclusion:The allergic rhinitis in guinea pigs accompany with the allergic asthma.The inhibitory capacity of anti-TNF-αand IL-1βIgY on pathological responses in guinea pigs with allergic rhinitis may be due to the significant decrease in the infiltration of eosinophils and the expressions of inflammatory cytokines in the nasal mucosas and lung tissues .

Objective To investigate the quality of life and its influencing factors in hver transplantation recipients in order to supply scientific reference for improving their life quality.Methods 33 patients with terminal liver diseases waiting for liver transplantation(the pre-operation group)and 102 patients 2 weeks after liver transplantation and outpatients for follow-up visits(the post-operation group)were conducted with SF-36,self-rating anxiety scale,self-rating depression scale,and social support questionnaire.Results Except for the scores of physiological function,emotional role,social function in SF-36.differences of scores of other factors were evident between the preand post-operation groups.Life quality of patients over 1 year after operation was better than those within 1 year. The influencing factors of QOL were subjective support and anxiety.Conclusions After liver transplantation,the patients' QOL evidently improves.Life quality of patients over 1 year after operation was better than those within 1 year.Patients' QOL is positively related to subjective support,negatively related to anxiety.

OBJECTIVETo understand the Escherichia coli O157:H7 carrier rate of host animals and the toxic gene of the strains in different areas in Jiangsu province.

METHODSSurveillance spots were set up in different areas, to collect feces of pigs, chickens, sheep, cattle to culture for O157:H7 with immunomagnetic separation as well as detection of toxic gene of the strain with MPCR were both carried out.

RESULTSOne hundred and seventy strains of O157:H7 were separated from 1 767 feces of different animals in six spots, with a overall positive rate 9.62%. The positive rates of cattle and sheep were 19.05% and 12.01% respectively. Among 85 strains SLT1, SLT2, eaeA and hly toxic genes were detected. In which, 56.47% of the strains were positive curturely while 79.17% of them carried SLT2, eaeA and hly gene simultaneously.

CONCLUSIONThe positive rate of O157:H7 in animals and the positive rates of strains were correlated to the incidence of the area. The highest rates were seen in areas where there had been O157:H7 epidemic, followed by the areas where there were only scattered cases identified while the lowest was in areas with no patients. Data indicated that it was important to enforce the surveillance of O157:H7 in animals to better predict and control of the disease.

Animals ; Cattle ; microbiology ; Chickens ; microbiology ; China ; Escherichia coli O157 ; isolation & purification ; Rabbits ; microbiology ; Sheep ; microbiology ; Swine ; microbiology ; Time Factors