Objective:To investigate the current status of nursing service quality from patients' perspectives and analyze its influencing factors.Methods:A convenience sampling method was used to select 615 adult inpatients who met the inclusion and exclusion criteria from two tertiary general hospitals and one secondary general hospital between April and June 2024. Patients from 22 clinical departments, including internal medicine, surgery, gynecology, otorhinolaryngology, traditional Chinese medicine, and rehabilitation, were surveyed using a demographic questionnaire and the nursing service quality evaluation scale from patients' perspective.Results:The overall nursing service quality score from patients' perspective was (106.18±12.80) points, with a standardized score of (84.94±10.24) points. Among the four modules, the highest to lowest scores were: emotional and psychological support, professional and technical competence, information and communication, and comfort and convenience, with standardized scores of (87.53±10.83), (87.23±9.87), (84.97±11.83), and (80.74±12.57), respectively. The top three ranked dimensions were respect, professionalism, and safety, while the lowest three were guidance, comfort, and convenience. Multiple linear regression analysis showed that daytime nurse-to-patient ratio, night-shift nurse-to-patient ratio, patients' education level, and patient age were significant influencing factors of nursing service quality from patients' perspectives ( P<0.05) . Conclusions:Nursing service quality from patients' perspectives was at a good level. Department-level factors influencing nursing service quality were primarily nurse-to-patient ratios, while patient-level factors included age and education level.

Objective:To investigate the current status of nursing service quality from patients' perspectives and analyze its influencing factors.Methods:A convenience sampling method was used to select 615 adult inpatients who met the inclusion and exclusion criteria from two tertiary general hospitals and one secondary general hospital between April and June 2024. Patients from 22 clinical departments, including internal medicine, surgery, gynecology, otorhinolaryngology, traditional Chinese medicine, and rehabilitation, were surveyed using a demographic questionnaire and the nursing service quality evaluation scale from patients' perspective.Results:The overall nursing service quality score from patients' perspective was (106.18±12.80) points, with a standardized score of (84.94±10.24) points. Among the four modules, the highest to lowest scores were: emotional and psychological support, professional and technical competence, information and communication, and comfort and convenience, with standardized scores of (87.53±10.83), (87.23±9.87), (84.97±11.83), and (80.74±12.57), respectively. The top three ranked dimensions were respect, professionalism, and safety, while the lowest three were guidance, comfort, and convenience. Multiple linear regression analysis showed that daytime nurse-to-patient ratio, night-shift nurse-to-patient ratio, patients' education level, and patient age were significant influencing factors of nursing service quality from patients' perspectives ( P<0.05) . Conclusions:Nursing service quality from patients' perspectives was at a good level. Department-level factors influencing nursing service quality were primarily nurse-to-patient ratios, while patient-level factors included age and education level.

As a new type of functional wound dressing, conductive hydrogel, shows broad prospects of application in the field of wound repair due to its suitable electrical conductivity, good moisture retention, excellent biocompatibility, and biological effects such as mediating cell migration and proliferation, and promoting angiogenesis and collagen deposition. Combined with the clinical electrical stimulation therapy, the conductive hydrogel primarily showed curative effects of promoting granulation tissue formation, re-epithelialization, and wound healing, providing a new treatment idea for the repair of diabetic wounds. This review summarized the research advances of electronic conductive hydrogels and ionic conductive hydrogels in recent years based on different conductive mechanisms. Meanwhile, the applications of conductive hydrogel in the diabetic wound repair were specifically introduced, and the future development of conductive hydrogel wound dressing was prospected.

Objective To explore the association of H3K14 acetylation (ac) with arsenicosis induced by coal-burning and arsenic-induced genetic damage,which might help us to find an biomarker to monitor the arsenicosis and arsenic-induced toxicity.Methods Totally 151 arsenicosis subjects were recruited from Jiaole Village of Xingren County,Guizhou.According to "National Principle for Diagnosis of Arsenicosis" (WS/T 211-2001),the arsenicosis group was divided into 3 subgroups:mild poisoning (n =62),intermediate poisoning (n =50) and severe poisoning (n =39).The control group was comprised of 78 healthy villagers from Jiaole Village who were exhibited no signs of arseniasis.The hair,the urine and the peripheral blood samples were collected from the subjects.The contents of arsenic in the hair samples were analyzed with inductively coupled plasma mass spectrometry.Histones were extracted from human peripheral blood lymphocytes (PBLCs) using the method of acid extraction.The levels of H3K14ac was measured with a sandwich enzyme-linked immunosorbent assay (ELISA).The rate of micronucleus (MN) and chromosome aberration (CA) of peripheral blood lymphocytes were examined by genetic methods.The levels of urinary 8-hydroxy-2 deoxyguanosine (8-OHdG) in all the subjects were measured with the high performance liquid lhromatography-mass spectrometry (HPLC-MS).Results ①The association of arsenic-exposure with arsenicosis induced by coal-burning and H3K14ac:The levels of hair arsenic in arsenicosis group [0.27(0.15-0.39) μg/g] was significant higher than that in control group [0.15 (0.08-0.20) μg/g,F=10.736,P ＜ 0.01].The degree of arsenicosis was positive correlation with the hair-arsenic level (r =0.363,P ＜ 0.05).The levels of H3K14ac was also positive correlation with the hair-arsenic level (r =0.385,P ＜ 0.05).②The association of H3K14ac and arsenicosis induced by coal-burning:The levels of H3K14ac in arsenicosis group (4.07 ± 4.03) was 2.5-fold higher than that in control group (1.62-± 1.19,F =19.753,P ＜ 0.01).H3K14ac was a risk factor of arsenicosis,the risk of arsenicosis increased correspondingly with the levels of H3K14ac [OR (95％CI) =1.779 (1.323-2.392),P ＜ 0.01].③The correlation of H3K14ac and the degree of arsenicosis:Based on the degree of arsenicosis,we found a significant difference in the levels of H3K14ac among the four groups (F =7524,P ＜ 0.01).Compared with the non-poisoning group (1.62 ± 1.19),the levels of H3K14ac in mild poisoning,intermediate poisoning and severe poisoning subgroups (3.70 ± 3.20,4.95 ± 5.47,3.49 ± 2.62) were increased (all P ＜ 0.01),but there were no significant differences in the levels of H3K14ac between the mild poisoning,intermediate poisoning and severe poisoning subgroups (P ＞ 0.05).(④)The genetic damage of all subjects:The rate of MN (2.03 ± 1.55) and CA (12.44 ± 5.01) in arsenicosis group were significantly higher than those in control group (MN:1.17 ± 0.97,Wald =14.121;CA:6.29 ± 2.41,Wald =83.164,P ＜ 0.05).Urinary 8-OHdG was increased in arsenicosis group than that in control group [(3.80 ± 3.88),(2.33 ±1.34) μg/g Cr,F =6.116,P ＜ 0.05].⑤The association of H3K14ac with genetic damage:The results revealed that H3K14ac modification was positively correlated with the rate of CA (β =0.84,P ＜ 0.01).The level of H3K14ac was not significantly associated with the rate of MN and urinary 8-OHdG (MN:β =0.10,P ＞ 0.05;8-OHdG:β=0.05,P ＞ 0.05).Conclusions The increase of H3K14ac modification in human peripheral blood lymphocytes is a risk factor of arsenic poisoning.Additionally,the dysregulation of H3K14ac was significant association with arsenic-induced chromosomal aberrations.