Objective:To investigate the value of carotid，radial and podalic artery intima thickness（CIT，RIT，PIT）combined with monocyte to high-density lipoprotein ratio（MHR）in predicting the severity of coronary artery stenosis in patients with premature coronary artery disease（PCAD）.Methods:A total of 80 patients with PCAD who received treatment in Henan Provincial People's Hospital from October 2023 to May 2024 were prospectively recruited，and they were divided into high group（≥41 score，40 cases）and low group（＜41 score，40 cases）according to the median dichotomy of Gensini score. Thirty-four gender，age and body mass index（BMI）-matched healthy volunteers were selected as the control group. The CIT，RIT，PIT，media and intima media thickness of carotid，radial artery and podalic artery（CMT，RMT，PMT，CIMT，RIMT，PIMT）were measured using 24 MHz ultra-high frequency ultrasound probe，and the ratio of intima to media thickness（CIT/CMT，RIT/RMT，PIT/PMT）was calculated. The differences of general clinical data，laboratory indexes and ultrasonic parameters among the three groups were compared. Risk factors affecting the severity of coronary stenosis in PCAD patients were explored by binary logistic regression. Subject working characteristic curves were plotted，area under the curve（AUC）was calculated，and the values of each ultrasound parameter and MHR in the independent and combined diagnosis of the severity of coronary artery stenosis in PCAD patients were evaluated.Results:①There were no statistically significant differences in age，gender，BMI，total cholesterol，CMT，RMT and PMT among the three groups（all P＞0.05）. There were no statistically significant differences in the comparison of smoking，hypertension，diabetes mellitus，systolic blood pressure，diastolic blood pressure，low-density lipoprotein cholesterol，total cholesterol，and triglycerides between the two subgroups of the PCAD（all P>0.05）. ②CIT，CIMT，CIT/CMT，RIT，RIMT，RIT/RMT，PIT，PIMT，PIT/PMT were thickened in the high group compared with the low group，and MHR was higher than in the low group（all P<0.05），the differences in the above parameters remained statistically significant when comparing the PCAD group with the control group（all P<0.05）. ③The AUC values for MHR，CIT，RIT and PIT alone to predict the severity of coronary stenosis in patients with PCAD were 0.781，0.767，0.780 and 0.722，respectively. The combined diagnostic efficiency of the four parameters was better than the independent diagnostic efficiency（AUC = 0.885）. Conclusions:CIT，RIT and PIT are thicker in PCAD patients with high Gensini score and the combination of artery intima thickness and MHR has good efficacy in predicting the severity of coronary artery stenosis in PCAD patients.

Objective:To investigate the value of carotid，radial and podalic artery intima thickness（CIT，RIT，PIT）combined with monocyte to high-density lipoprotein ratio（MHR）in predicting the severity of coronary artery stenosis in patients with premature coronary artery disease（PCAD）.Methods:A total of 80 patients with PCAD who received treatment in Henan Provincial People's Hospital from October 2023 to May 2024 were prospectively recruited，and they were divided into high group（≥41 score，40 cases）and low group（＜41 score，40 cases）according to the median dichotomy of Gensini score. Thirty-four gender，age and body mass index（BMI）-matched healthy volunteers were selected as the control group. The CIT，RIT，PIT，media and intima media thickness of carotid，radial artery and podalic artery（CMT，RMT，PMT，CIMT，RIMT，PIMT）were measured using 24 MHz ultra-high frequency ultrasound probe，and the ratio of intima to media thickness（CIT/CMT，RIT/RMT，PIT/PMT）was calculated. The differences of general clinical data，laboratory indexes and ultrasonic parameters among the three groups were compared. Risk factors affecting the severity of coronary stenosis in PCAD patients were explored by binary logistic regression. Subject working characteristic curves were plotted，area under the curve（AUC）was calculated，and the values of each ultrasound parameter and MHR in the independent and combined diagnosis of the severity of coronary artery stenosis in PCAD patients were evaluated.Results:①There were no statistically significant differences in age，gender，BMI，total cholesterol，CMT，RMT and PMT among the three groups（all P＞0.05）. There were no statistically significant differences in the comparison of smoking，hypertension，diabetes mellitus，systolic blood pressure，diastolic blood pressure，low-density lipoprotein cholesterol，total cholesterol，and triglycerides between the two subgroups of the PCAD（all P>0.05）. ②CIT，CIMT，CIT/CMT，RIT，RIMT，RIT/RMT，PIT，PIMT，PIT/PMT were thickened in the high group compared with the low group，and MHR was higher than in the low group（all P<0.05），the differences in the above parameters remained statistically significant when comparing the PCAD group with the control group（all P<0.05）. ③The AUC values for MHR，CIT，RIT and PIT alone to predict the severity of coronary stenosis in patients with PCAD were 0.781，0.767，0.780 and 0.722，respectively. The combined diagnostic efficiency of the four parameters was better than the independent diagnostic efficiency（AUC = 0.885）. Conclusions:CIT，RIT and PIT are thicker in PCAD patients with high Gensini score and the combination of artery intima thickness and MHR has good efficacy in predicting the severity of coronary artery stenosis in PCAD patients.

Referring to ZHANG Xichun's experience in treating dysentery from cold-fire accumulation， the treatment of ulcerative colitis （UC） in this paper can be divided into three stages including cold-fire accumulation stage， excessive heat and putrid intestine stage， and healthy qi deficiency and pathogen lingering stage. For people with slippery and excess pulse in the cold-fire accumulation stage， Xiaochengqi Decoction （小承气汤） added with Baishao （Radix Paeoniae Alba） and Gancao （Radix et Rhizoma Glycyrrhizae） can be used for purgation， while those with deficient pulse， Huazhi Decoction （化滞汤） or Xieli Decoction （燮理汤） can be used. In the excessive heat and putrid intestine stage， Tongbian Baitouweng Decoction （通变白头翁汤） and Jiedu Shenghua Elixir （解毒生化丹） are suggested. In the healthy qi deficiency and pathogen lingering stage， it is advised to use Jiedu Shenghua Elixir added with Shanyao （Rhizoma Dioscoreae）， and Sanbao Porridge （三宝粥）. Additionally， the medication rules， dosage and administration characteristics of Huanglian （Rhizoma Coptidis）-Rougui （Cortex Cinnamomi）， Yadanzi （Fructus Bruceae）， Diyu （Radix Sanguisorbae）， Shanyao and Liuhuang （Sulphur） by ZHANG Xichun have been summarized with the help of modern pharmacological research， so as to provide new ideas for the treatment of UC by TCM.

The difficulty of wound healing in patients is a difficult problem that doctors in all clinical departments may encounter, and there is still no good solution. Resveratrol is a kind of natural active substance, which has anti-inflammatory, antioxidant, antibacterial, and angiogenesis promoting effects, and is a potential drug to promote wound healing. However, the clinical application of resveratrol is limited due to its low bioavailability. In this review, the molecular mechanism of resveratrol in promoting wound healing and its administration methods in wound treatment were reviewed to provide ideas for the redevelopment of resveratrol.

Objective To explore changes of left atrial(LA)volume and function in ankylosing spondylitis(AS)patients with different activity by using ultrasound four-dimensional auto LA quantification(4D Auto LAQ)technique.Methods Eighty-nine AS patients were retrospectively selected and divided into remission group(group A,n=20),low activity group(group B,n=25),high activity group(group C,n=23)and very high activity group(group D,n=21)according to AS disease activity score-C reactive protein(ASDAS-CRP).Meanwhile,54 healthy adults with age and gender matched were recruited as control group.Conventional echocardiographic parameters and LA volume and strain parameters obtained with 4D Auto LAQ technique were compared among groups.Multiple ordinal logistic regression was used to analyze the correlations of LA volume and strain parameters with AS disease activity.Results The ratio of early diastolic peak flow velocity of mitral orifice to early diastolic velocity of lateral mitral annulus(E/e')and LA minimum volume(LAVmin),the maximum volume(LAVmax),presystolic volume(LAVpre),ejection fraction(LAEF),active ejection fraction(LAaEF)and passive ejection fraction(LApEF)were all significantly different among groups,so were LA longitudinal strain during reservoir phase(LASr-l),conduit phase(LAScd-l),contraction phase(LASct-l)and circumferential strain during reservoir phase(LASr-c),conduit phase(LAScd-c)and contraction phase(LASct-c)(all P＜0.001).LAVmin was positively correlated(OR=7.106,B=1.96),while LASr-l and LASct-l were negatively correlated with AS activity(OR=0.235,0.145,B=-1.44,-1.93).Conclusion With the increase of disease activity,LAVmin in AS patients gradually increased,while LASr-l and LASct-l gradually decreased.

Objective To explore changes of left atrial(LA)volume and function in ankylosing spondylitis(AS)patients with different activity by using ultrasound four-dimensional auto LA quantification(4D Auto LAQ)technique.Methods Eighty-nine AS patients were retrospectively selected and divided into remission group(group A,n=20),low activity group(group B,n=25),high activity group(group C,n=23)and very high activity group(group D,n=21)according to AS disease activity score-C reactive protein(ASDAS-CRP).Meanwhile,54 healthy adults with age and gender matched were recruited as control group.Conventional echocardiographic parameters and LA volume and strain parameters obtained with 4D Auto LAQ technique were compared among groups.Multiple ordinal logistic regression was used to analyze the correlations of LA volume and strain parameters with AS disease activity.Results The ratio of early diastolic peak flow velocity of mitral orifice to early diastolic velocity of lateral mitral annulus(E/e')and LA minimum volume(LAVmin),the maximum volume(LAVmax),presystolic volume(LAVpre),ejection fraction(LAEF),active ejection fraction(LAaEF)and passive ejection fraction(LApEF)were all significantly different among groups,so were LA longitudinal strain during reservoir phase(LASr-l),conduit phase(LAScd-l),contraction phase(LASct-l)and circumferential strain during reservoir phase(LASr-c),conduit phase(LAScd-c)and contraction phase(LASct-c)(all P＜0.001).LAVmin was positively correlated(OR=7.106,B=1.96),while LASr-l and LASct-l were negatively correlated with AS activity(OR=0.235,0.145,B=-1.44,-1.93).Conclusion With the increase of disease activity,LAVmin in AS patients gradually increased,while LASr-l and LASct-l gradually decreased.

After the compatibility of Astragali Radix and Atractylodis Macrocephalae Rhizoma, most of the effective components of Astragali Radix increase, and the bioavailability is improved. Compared with the application of the two drugs alone, it can enhance the effects of immune regulation, anti-tumor, diuresis, lung protection, regulation of flora, and intestinal protection. However, the optimal compatibility ratio of Astragali Radix- Atractylodis Macrocephalae Rhizoma pair to exert various pharmacological effects still needs to be clarified. The drug pair and related preparations are mostly used in the treatment of nephropathy, but its mechanism of action needs to be further elucidated.

Objective:To investigate the medicinal plant resources in Saertu District, Heilongjiang Province so as to provide scientific foundation for the protection rational development and utilization of wild medicinal plant resources in this region.Methods:According to the technical specification requirements of the fourth national census of Traditional Chinese Medicine (TCM) resources, the wild medicinal plant resources in Saertu area were analyzed.Results:A total of 36 samples were completed, in this survey among which contains a total of 166 species of wild medicinal plant resources, belonging to 118 genera of 45 families, including 37 species of key medicinal materials.Conclusion:The TCM resource in Saertu is relatively scarce, and the species and resource distribution of TCM in this region have been basically found out, which can provide reliable information for the establishment of TCM resource protection zones in Saertu and expanded to the entire province.

The incidence of postoperative excessive bleeding and reexploration is relatively high, and it will bring a series of serious complications, such as an additional surgery, a longer intensive care unit stay, longer time on mechanical ventilation, an increase need of allogeneic blood product transfusions and increased mortality. However, the understanding of postoperative excessive bleeding and reexploration in China is significantly different from the international level, and the understanding of postoperative excessive bleeding and reexploration after cardiac surgery in clinical work is still not enough. This review will focus on some problems, such as related factors analysis of postoperative excessive bleeding, hemostatic process optimization and the serious complications of reexploration after cardiac surgery.

Objective: To explore the differences and correlation between the target volumes based on deformation registration (DIR) using preoperative prone diagnostic magnetic resonance (MR) imaging and postoperative prone computed tomography (CT) simulation imaging for patients undergoing breast-conserving surgery (BCS). Methods: Eighteen breast cancer patients suitable for external-beam partial breast irradiation (EB-PBI) after BCS were enrolled. Preoperative prone diagnostic MR and postoperative prone CT scan sets were acquired during free breathing for all patients. The gross tumor volume (GTV) delineated on the preoperative diagnostic MR images was defined as GTV_MRI, the clinical target volumes (CTV_{MRI+ 1} and CTV_{MRI+ 2})were defined as 10 and 20 mm margins around the GTV_MRI, and the planning target volume (PTV_{MRI+ 1} and PTV_{MRI+ 2}) were defined as 15 and 25 mm margins around the GTV_MRI, respectively. Tumor bed (TB) delineated on the postoperative prone CT simulation images acquired during free breathing was defined as GTV_TB, CTV and PTV were defined as 10 and 15 mm margins around the GTV_TB, respectively. The target volume of the whole breast contoured on the MR and CT images were defined as CTV_Breast-MRI and CTV_Breast-CI, respectively. The MR and CT images were registered deformably in MIM software system. Results: The GTV_TB, CTV_TB and PTV_TB were significantly greater than GTV_MRI, GTV_{MRI+ 1} and PTV_{MRI+ 1}, respectively (Z=-3.593, -3.593, -2.983, P<0.05). Meanwhile, the CTV_TB and PTV_TB were significantly less than the CTV_{MRI+ 2} and PTV_{MRI+ 2}, respectively(Z=-2.722, -2.853, P<0.05). The conformal index (CI) and degree of inclusion (DI) of GTV_TB-GTV_MRI, GTV_TB-CTV_{MRI+ 1}, CTV_TB-GTV_MRI and CTV_TB-GTV_{MRI+ 1} based on center-coincidence of the compared targets were better than those based on DIR of the thorax(Z=-3.724、-3.724、-2.591、-3.593, P<0.05; Z=-3.724、-3.724、-3.201、-3.724, P<0.05). Conclusions For the patients enrolled for prone EB-PBI, target volumes delineated on the preoperative prone MR images were significantly smaller compared to that on the postoperative prone CT images, but a statistically significant positive correlation was found between the MR and CT target volumes. There were still relatively poor spatial overlap whether for the whole breast or the targets between the preoperative prone diagnostic MR images and the postoperative prone simulation CT images based on DIR. Therefore, it is infeasible to guide postoperative EB-PBI target delineation using the preoperative prone diagnostic MR images.