OBJECTIVES: To construct an intelligent analysis model for classifying fetal orientation during intrapartum ultrasound videos based on multi-feature fusion. METHODS: The proposed model consists of the Input, Backbone Network and Classification Head modules. The Input module carries out data augmentation to improve the sample quality and generalization ability of the model. The Backbone Network was responsible for feature extraction based on Yolov8 combined with CBAM, ECA, PSA attention mechanism and AIFI feature interaction module. The Classification Head consists of a convolutional layer and a softmax function to output the final probability value of each class. The images of the key structures (the eyes, face, head, thalamus, and spine) were annotated with frames by physicians for model training to improve the classification accuracy of the anterior occipital, posterior occipital, and transverse occipital orientations. RESULTS: The experimental results showed that the proposed model had excellent performance in the tire orientation classification task with the classification accuracy reaching 0.984, an area under the PR curve (average accuracy) of 0.993, and area under the ROC curve of 0.984, and a kappa consistency test score of 0.974. The prediction results by the deep learning model were highly consistent with the actual classification results. CONCLUSIONS The multi-feature fusion model proposed in this study can efficiently and accurately classify fetal orientation in intrapartum ultrasound videos.
Humans ; Female ; Ultrasonography, Prenatal/methods* ; Pregnancy ; Fetus/diagnostic imaging* ; Neural Networks, Computer ; Video Recording

Objective We aimed to investigate the effects of different non-surgical embryo transfer devices,number of transferred embryos,embryo stage,and embryos obtained from different mouse strains on the efficiency of non-surgical embryo transfer in mice,and to compare the efficiencies of surgical and non-surgical embryo transfer,in order to establish a stable non-surgical embryo transfer technology system.Methods Mouse embryo transfer was carried out using non-surgical method.Results The pregnancy rates using two different non-surgical transfer devices were(75.00±0.00)％and(66.67±14.43)％,and the birth rates were(46.11±6.31)％and(18.89±0.96)％,respectively.Transfer of 10,15,and 20 embryos resulted in pregnancy rates of(66.67±11.55)％,(80.00±0.00)％,and(66.67±23.09)％,and birth rates of(29.33±4.16)％,(38.67±4.81)％,and(17.00±3.46)％,respectively.When blastocysts and morulae were transferred non-surgically,the resulting pregnancy rates were(80.00±0.00)％and(46.67±11.55)％and the birth rates were(38.67±4.81)％and(10.22±2.77)％,respectively.Four strains(C57BL/6J,ICR,genetically modified mice A,genetically modified mice B)were used as donors for non-surgical embryo transfer,with resulting pregnancy rates of(66.67±11.55)％,(80.00±0.00)％,(73.33±11.55)％,and(80.00±0.00)％,and birthrates of(26.67±2.67)％,(38.67±4.81)％,(32.00±3.53)％,and(29.34±2.31)％,respectively.Fifteen pseudo-pregnant mice were transplanted surgically and 15 were transplanted non-surgically,with pregnancy rates of(80.00±0.00)％and(86.67±11.55)％,and birth rates of(38.67±4.81)％and(36.00±5.82)％,respectively.Conclusions Transfer device A resulted in a higher birth rate in this study.The embryo transfer efficiency was higher when 15 embryos were transferred into unilateral uterine horns of pseudo-pregnant 2.5-day recipients.Blastocyst-stage embryo transfer was more efficient than morula-stage transfer.There was no significant difference in efficiency between surgical and non-surgical embryo transfer procedures.

Objective We aimed to investigate the effects of different non-surgical embryo transfer devices,number of transferred embryos,embryo stage,and embryos obtained from different mouse strains on the efficiency of non-surgical embryo transfer in mice,and to compare the efficiencies of surgical and non-surgical embryo transfer,in order to establish a stable non-surgical embryo transfer technology system.Methods Mouse embryo transfer was carried out using non-surgical method.Results The pregnancy rates using two different non-surgical transfer devices were(75.00±0.00)％and(66.67±14.43)％,and the birth rates were(46.11±6.31)％and(18.89±0.96)％,respectively.Transfer of 10,15,and 20 embryos resulted in pregnancy rates of(66.67±11.55)％,(80.00±0.00)％,and(66.67±23.09)％,and birth rates of(29.33±4.16)％,(38.67±4.81)％,and(17.00±3.46)％,respectively.When blastocysts and morulae were transferred non-surgically,the resulting pregnancy rates were(80.00±0.00)％and(46.67±11.55)％and the birth rates were(38.67±4.81)％and(10.22±2.77)％,respectively.Four strains(C57BL/6J,ICR,genetically modified mice A,genetically modified mice B)were used as donors for non-surgical embryo transfer,with resulting pregnancy rates of(66.67±11.55)％,(80.00±0.00)％,(73.33±11.55)％,and(80.00±0.00)％,and birthrates of(26.67±2.67)％,(38.67±4.81)％,(32.00±3.53)％,and(29.34±2.31)％,respectively.Fifteen pseudo-pregnant mice were transplanted surgically and 15 were transplanted non-surgically,with pregnancy rates of(80.00±0.00)％and(86.67±11.55)％,and birth rates of(38.67±4.81)％and(36.00±5.82)％,respectively.Conclusions Transfer device A resulted in a higher birth rate in this study.The embryo transfer efficiency was higher when 15 embryos were transferred into unilateral uterine horns of pseudo-pregnant 2.5-day recipients.Blastocyst-stage embryo transfer was more efficient than morula-stage transfer.There was no significant difference in efficiency between surgical and non-surgical embryo transfer procedures.

Depression is a common mental disorder characterized primarily by low mood accompanied by cognitive and behavioral changes. The commonly used antidepressants are not fast onset. Even with a long term pharmacotherapy, relapse rate is still quite high. Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that has been increasingly used in the treatment of depression in recent years. Since depression is associated with abnormalities in endogenous neural oscillations and synaptic plasticity in the brain, tACS can influence these process, thereby treating depression. Different frequencies of tACS stimulation can improve depressive symptoms, with gamma (γ) and alpha (α) frequencies receiving the most attention. This article primarily reviews the potential mechanisms of tACS and the application of tACS at different frequencies in treating depression, aiming to further explore the feasibility of tACS in the treatment of depression.

Cognitive dysfunction is the impairment of higher brain functions.Cognitive impairment caused by neuropsychiatric diseases has caused serious impact on patients'quality of life and the outcome of the disease.The transcranial alternating current stimulation(tACS)improves cognitive function by modulating neural oscillations of specific frequencies,affecting the release of neurotransmitters such as serotonin and dopamine,and enhancing local and distal synchronization of brain networks.Specific frequencies of tACS can improve the cognitive impairment caused by Alzheimer disease(AD),schizophrenia,and depression,among which the gamma and theta frequencies of tACS have the most significant effects on cognitive function.tACS has high safety and low operational difficulty,and has great potential to improve cognitive function.

Depression is a common mental disorder characterized primarily by low mood accompanied by cognitive and behavioral changes. The commonly used antidepressants are not fast onset. Even with a long term pharmacotherapy, relapse rate is still quite high. Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that has been increasingly used in the treatment of depression in recent years. Since depression is associated with abnormalities in endogenous neural oscillations and synaptic plasticity in the brain, tACS can influence these process, thereby treating depression. Different frequencies of tACS stimulation can improve depressive symptoms, with gamma (γ) and alpha (α) frequencies receiving the most attention. This article primarily reviews the potential mechanisms of tACS and the application of tACS at different frequencies in treating depression, aiming to further explore the feasibility of tACS in the treatment of depression.

ObjectiveTo investigate the willingness of middle school students to engage in medicine and its influencing factors during COVID-19 pandemic in Lanzhou， so as to provide references for the early career planning education on middle school students. MethodsConvenient sampling method was used to choose 1 795 middle school students from 5 schools in Lanzhou from July 21 to July 31， 2022 for this study where an online questionnaire survey was distributed to collect data. A self-compiled questionnaire was used to gather the general information， assess the willingness to engage in medicine and seek the underlying reasons. The psychological resilience level of students was assessed using Resilience Scale for Adolescents. Then multivariate Logistic regression analysis was conducted to screen the factors associated with the willingness of middle school students to engage in medicine. ResultsAfter the local outbreak of COVID-19 in Lanzhou， 835 （46.52%） middle school students demonstrated their willingness to engage in medicine， and the top three reasons for their willingness were being affected by medical staff during the pandemic （75.69%）， having interests in medical sciences （67.31%）， and the potential increase of attention to national medical development after the epidemic （43.23%）. Logistical regression analysis showed that female gender （OR=1.438， P<0.01）， family members engaged in the medical and health industry （OR=1.574， P<0.01） and having a high psychological resilience score （OR=1.011， P<0.01） were related to the clear willingness to engage in medicine， while studying in senior middle school （OR=0.473， P<0.01） and excessive exposure （≥50%） to negative information during the epidemic （OR=0.797， P<0.05） were related to declining willingness to engage in medicine. ConclusionAfter the COVID-19 outbreak in Lanzhou， a large proportion of local middle school students show their willingness to engage in medicine， especially among those of female gender， having family members engaged in the medical and health industry and having high level of psychological resilience. Whereas students studying in senior middle school and with excessive exposure to negative information during the outbreak indicate low willingness to engage in medicine.

Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation. Currently, the therapeutic role of ferroptosis on cancer is gaining increasing interest. Baicalin an active component in

Objective To explore the effect of behavior training on the rehabilitation of homeless patients with schizophrenia .Methods Totals of 72 homeless patients with schizophrenia were randomly divided into study group and control group with 36 cases in each group .Both groups received the routine treatment and care, and the study group received behavior training in addition .The Nurse Observation Scale for Inpatient Evaluation(NOSIE)and the Quality of Life Questionnaire for Psychiatric patients (QOL-P)were used to evaluate the rehabilitation effectiveness before and 8 weeks after behavior training .Results There were no differences in NOSIE and QOL-P scores in patients before behavior training ( P >0.05 ).While 8 weeks after behavior training, NOSIE scores of personal hygiene (19.06 ±3.15),social interest (16.89 ±2.64) and social competence (20.11 ±2.79)in study group were higher than(14.44 ±2.71),(12.28 ±2.71),(13.67 ±2.22) in control group,and the differences were statistically significant (t=6.656,7.314,10.086,respectively;P<0.01).Irritation(12.00 ±3.28)and retardation(8.61 ±2.78)scores were significantly lower than (17.33 ± 2.99),(14.00 ±2.53)in control group(t=7.218,8.602,respectively;P<0.01).The total score of QOL-P (54.58 ±8.77) in study group was lower than (77.78 ±5.49) in control group,and the difference was statistically significant(t=13.443,P<0.01).Conclusions Behavior training helps to improve the life ability and social function of homeless patients with schizophrenia .It has a positive effect for enhancing the quality of life of patients and promoting the rehabilitation of the disease.

Objective To explore the composition of the high risk events in delivery room ,and then investigate the measure-ments improving the nursing quality .Methods Pareto principle was used to analyses the composition of high risk events in delivery room from January 2010 to June 2012 in a third-grade class-A hospital in Jiangsu province .Results Among all the high risk e-vents ,low satisfaction with nursing care took more than 80% proportion of the total events ,it was called the A events .The dysto-cia ,acute production ,bleeding ,umbilical cord prolapse ,etc cumulative constitute 91% -100% proportion(C events) .Conclusion Managers in delivery room must take measures to improve the paritys`satisfaction with the nursing care ,meanwhile ,other high risk events should also be solved .