[Objective]To explore the inheritance thread of ZHANG's orthopedics department of Zhejiang school of traditional Chinese medicine(TCM)and the origin of the thought of"harmony",to sum up its academic characteristics,and enrich and develop the theoretical connotation of ZHANG's orthopedics department.[Methods]Through visiting the descendants and inheritors of ZHANG's orthopedics department,collecting and sorting out the existing manuscripts,case examination and other documents,consulting the ancient relevant orthopedic books,and summarizing their academic thoughts and characteristics.[Results]ZHANG's orthopedics department inherits the essence of Taoist culture,absorbs the essence of Confucian thought,inherits the essential technique of Buddhist bone-setting,relays the specialty of folk therapy,combines the technology of modern medicine,dedicates 200 years to medicine and inherits the feelings of helping the world.It has formed an academic school of orthopedics of TCM with the thought of"harmony"as the core,and featured with the theoretical system of holistic syndrome differentiation and comprehensive therapy,Qi and blood regulation,mutual use of muscles and bones,static and dynamic complementation,combination of prevention and treatment,and integration of form and spirit.[Conclusion]ZHANG's orthopedics department has learned from others,maintained the right path and innovation,laid equal emphasis on both Chinese and western.It has formed a complete and unique theoretical system of"harmony",which is of great significance to enrich the academic connotation of the orthopedics school of Zhejiang TCM and promote the cultural construction of"harmony"of the Chinese nation.

Objective:To explore the clinical features of chronic atrophic gastritis (CAG) without Helicobacter pylori ( H. pylori) infection and its correlation with metabolic syndrome. Methods:From June 1, 2022 to March 31, 2023, a total of 966 patients diagnosed with CAG at Army Medical Center of PLA (Chongqing Daping Hospital) were enrolled. All the patients underwent 14C-urea breath test and gastroscopy. The patients were divided into infected group (461 patients with H. pylori-positive CAG) and uninfected group (505 patients with H. pylori-negative CAG). Relevant data including age, body mass index, degree of gastric atrophy (Kimura-Takemoto classification), metabolic syndrome, diabetes mellitus, and hyperlipidemia were collected and compared between the 2 groups. Independent sample t-test and chi-square test were used for statistical analysis. Multiple linear regression analysis was performed to investigate the correlation between relevant indicators and the degree of gastric atrophy in the uninfected group patients. Results:The proportion of patients aged 71 to 80 years old in the uninfected group was higher than that in the infected group (17.0%, 86/505 vs.10.4%, 48/461), and the difference was statistically significant ( χ2=9.62, P=0.002). The degree of gastric atrophy was compared between the 2 groups, the proportions of C1 and C2 patients in the uninfected group were higher than those in the infected group (53.5%, 270/505 vs. 46.4%, 214/461; 34.1%, 172/505 vs. 26.24%, 121/461), and the differences were statistically significant ( χ2=4.78 and 6.96, both P<0.05). The proportions of patients with metabolic syndrome, diabetes mellitus, hyperlipidemia and obesity in the uninfected group were higher than those in the infected group (31.2%, 20/64 vs.14.8%, 9/61; 33.5%, 62/185 vs. 21.5%, 34/158; 31.3%, 67/214 vs. 7.8%, 36/461; 36.7%, 22/60 vs.19.7%, 12/61), and the differences were statistically significant ( χ2=4.77, 6.08, 4.95, and 4.32, all P<0.05). The results of multiple linear regression analysis showed that high density lipoprotein-cholesterol, blood glucose, and body mass index were all correlated with the degree of gastric atrophy ( r=-0.15, 0.20, and 0.31, all P<0.05). Conclusion:CAG without H. pylori infection may be related to physiological aging, and the degree of gastric atrophy is C1 and C2, which is related to metabolic syndrome.