Periodontitis is a common oral disease characterized by progressive alveolar bone resorption and inflammation of the periodontal tissues. Dimethyl fumarate (DMF) has been used in the treatment of various immune-inflammatory diseases due to its excellent anti-inflammatory and antioxidant functions. Here, we investigated for the first time the therapeutic effect of DMF on periodontitis. In vivo studies showed that DMF significantly inhibited periodontal destruction, enhanced mitophagy, and decreased the M1/M2 macrophage ratio. In vitro studies showed that DMF inhibited macrophage polarization toward M1 macrophages and promoted polarization toward M2 macrophages, with improved mitochondrial function, inhibited oxidative stress, and increased mitophagy in RAW 264.7 cells. Furthermore, DMF increased intracellular mitochondrial Tu translation elongation factor (TUFM) levels to maintain mitochondrial homeostasis, promoted mitophagy, and modulated macrophage polarization, whereas TUFM knockdown decreased the protective effect of DMF. Finally, mechanistic studies showed that DMF increased intracellular TUFM levels by protecting TUFM from degradation via the ubiquitin-proteasomal degradation pathway. Our results demonstrate for the first time that DMF protects mitochondrial function and inhibits oxidative stress through TUFM-mediated mitophagy in macrophages, resulting in a shift in the balance of macrophage polarization, thereby attenuating periodontitis. Importantly, this study provides new insights into the prevention of periodontitis.
Dimethyl Fumarate/pharmacology* ; Mitophagy/drug effects* ; Animals ; Mice ; Macrophages/metabolism* ; Periodontitis/prevention & control* ; RAW 264.7 Cells ; Oxidative Stress/drug effects* ; Peptide Elongation Factor Tu/metabolism* ; Mice, Inbred C57BL ; Male ; Mitochondria/drug effects*

Cemental tear is a rare and indetectable condition unless obvious clinical signs present with the involvement of surrounding periodontal and periapical tissues. Due to its clinical manifestations similar to common dental issues, such as vertical root fracture, primary endodontic diseases, and periodontal diseases, as well as the low awareness of cemental tear for clinicians, misdiagnosis often occurs. The critical principle for cemental tear treatment is to remove torn fragments, and overlooking fragments leads to futile therapy, which could deteriorate the conditions of the affected teeth. Therefore, accurate diagnosis and subsequent appropriate interventions are vital for managing cemental tear. Novel diagnostic tools, including cone-beam computed tomography (CBCT), microscopes, and enamel matrix derivatives, have improved early detection and management, enhancing tooth retention. The implementation of standardized diagnostic criteria and treatment protocols, combined with improved clinical awareness among dental professionals, serves to mitigate risks of diagnostic errors and suboptimal therapeutic interventions. This expert consensus reviewed the epidemiology, pathogenesis, potential predisposing factors, clinical manifestations, diagnosis, differential diagnosis, treatment, and prognosis of cemental tear, aiming to provide a clinical guideline and facilitate clinicians to have a better understanding of cemental tear.
Humans ; Dental Cementum/injuries* ; Consensus ; Diagnosis, Differential ; Cone-Beam Computed Tomography ; Tooth Fractures/therapy*

Performance appraisal of public hospitals have given a guidance for the development of public hospitals at all levels.A Class A tertiary hospital reviewed the problems in the development of the hospital at the present stage and focused on the following four aspects:①insufficient fine management;②No clear orientation of discipline development;③The bottleneck of the improvement of medical operation efficiency;④New challenges in the reform of payment mode.The tertiary hospital launched a fine management practice in May 2022,in order to solve the problems by taking the Department of Surgery as a pilot area,laying the foundation for fine management through information system construction,improving the efficiency of medical operation through management process optimization,improving the overall competitiveness of disciplines through the construction of sub-specialty and Discipline Alliance and adjusting the performance appraisal index system to play the role of performance incentives.The measures effectively improve the overall capacity and efficiency of hospital medical services and help the hospital to achieve high-quality development.

Objective: This study is the first to adopt a cultural and contextual coping model to examine the impact of forbearance coping on compliance and psychological health and unravel the psychosocial mediator and moderator among community-dwelling residents in the post-pandemic era in China. Methods: A multistage cluster convenience sampling strategy was conducted to recruit 402 community-dwelling residents of ten cities in Guangdong province who completed an online survey measuring forbearance coping, anti-pandemic compliance behaviours, family resilience, community resilience and psychological distress. Results: The study results showed an unexpected negative influence of forbearance coping on psychological distress. Nevertheless, forbearance coping facilitated personal compliance with coronavirus disease-2019 mitigation measures and improved psychological health. More importantly, meaning-making of adversity within families partially mediated the negative effect of forbearance on mental health only when respondents perceived higher levels of community resilience. Conclusion This study is the first to apply the cultural and contextual model of coping to Chinese individuals during a significant public health crisis. It expands the model by uncovering mechanisms like behavioural compliance and family meaning-making, and highlights the moderating role of community resilience. The findings emphasize the importance of building resilient communities and supporting mental health, providing evidence for future policy interventions and pandemic/disaster prevention measures in China.

Objective: This study is the first to adopt a cultural and contextual coping model to examine the impact of forbearance coping on compliance and psychological health and unravel the psychosocial mediator and moderator among community-dwelling residents in the post-pandemic era in China. Methods: A multistage cluster convenience sampling strategy was conducted to recruit 402 community-dwelling residents of ten cities in Guangdong province who completed an online survey measuring forbearance coping, anti-pandemic compliance behaviours, family resilience, community resilience and psychological distress. Results: The study results showed an unexpected negative influence of forbearance coping on psychological distress. Nevertheless, forbearance coping facilitated personal compliance with coronavirus disease-2019 mitigation measures and improved psychological health. More importantly, meaning-making of adversity within families partially mediated the negative effect of forbearance on mental health only when respondents perceived higher levels of community resilience. Conclusion This study is the first to apply the cultural and contextual model of coping to Chinese individuals during a significant public health crisis. It expands the model by uncovering mechanisms like behavioural compliance and family meaning-making, and highlights the moderating role of community resilience. The findings emphasize the importance of building resilient communities and supporting mental health, providing evidence for future policy interventions and pandemic/disaster prevention measures in China.

Objective: This study is the first to adopt a cultural and contextual coping model to examine the impact of forbearance coping on compliance and psychological health and unravel the psychosocial mediator and moderator among community-dwelling residents in the post-pandemic era in China. Methods: A multistage cluster convenience sampling strategy was conducted to recruit 402 community-dwelling residents of ten cities in Guangdong province who completed an online survey measuring forbearance coping, anti-pandemic compliance behaviours, family resilience, community resilience and psychological distress. Results: The study results showed an unexpected negative influence of forbearance coping on psychological distress. Nevertheless, forbearance coping facilitated personal compliance with coronavirus disease-2019 mitigation measures and improved psychological health. More importantly, meaning-making of adversity within families partially mediated the negative effect of forbearance on mental health only when respondents perceived higher levels of community resilience. Conclusion This study is the first to apply the cultural and contextual model of coping to Chinese individuals during a significant public health crisis. It expands the model by uncovering mechanisms like behavioural compliance and family meaning-making, and highlights the moderating role of community resilience. The findings emphasize the importance of building resilient communities and supporting mental health, providing evidence for future policy interventions and pandemic/disaster prevention measures in China.

Objective: This study is the first to adopt a cultural and contextual coping model to examine the impact of forbearance coping on compliance and psychological health and unravel the psychosocial mediator and moderator among community-dwelling residents in the post-pandemic era in China. Methods: A multistage cluster convenience sampling strategy was conducted to recruit 402 community-dwelling residents of ten cities in Guangdong province who completed an online survey measuring forbearance coping, anti-pandemic compliance behaviours, family resilience, community resilience and psychological distress. Results: The study results showed an unexpected negative influence of forbearance coping on psychological distress. Nevertheless, forbearance coping facilitated personal compliance with coronavirus disease-2019 mitigation measures and improved psychological health. More importantly, meaning-making of adversity within families partially mediated the negative effect of forbearance on mental health only when respondents perceived higher levels of community resilience. Conclusion This study is the first to apply the cultural and contextual model of coping to Chinese individuals during a significant public health crisis. It expands the model by uncovering mechanisms like behavioural compliance and family meaning-making, and highlights the moderating role of community resilience. The findings emphasize the importance of building resilient communities and supporting mental health, providing evidence for future policy interventions and pandemic/disaster prevention measures in China.

Objective: This study is the first to adopt a cultural and contextual coping model to examine the impact of forbearance coping on compliance and psychological health and unravel the psychosocial mediator and moderator among community-dwelling residents in the post-pandemic era in China. Methods: A multistage cluster convenience sampling strategy was conducted to recruit 402 community-dwelling residents of ten cities in Guangdong province who completed an online survey measuring forbearance coping, anti-pandemic compliance behaviours, family resilience, community resilience and psychological distress. Results: The study results showed an unexpected negative influence of forbearance coping on psychological distress. Nevertheless, forbearance coping facilitated personal compliance with coronavirus disease-2019 mitigation measures and improved psychological health. More importantly, meaning-making of adversity within families partially mediated the negative effect of forbearance on mental health only when respondents perceived higher levels of community resilience. Conclusion This study is the first to apply the cultural and contextual model of coping to Chinese individuals during a significant public health crisis. It expands the model by uncovering mechanisms like behavioural compliance and family meaning-making, and highlights the moderating role of community resilience. The findings emphasize the importance of building resilient communities and supporting mental health, providing evidence for future policy interventions and pandemic/disaster prevention measures in China.

Objective: To investigate the sleep and mental health status of adolescents in Shandong Province, to explore the correlation between sleep and mental health, so as to provide a basis for adolescent physical and mental health management. Methods: From February to March 2023,a multistage stratified whole cluster sampling method was used to randomly select 3 cities in Shandong Province, one urban area and one township in each city, one junior high school and one senior high school in the urban area and the township, respectively, and then 4 classes were randomly selected from each grade level of each school, and all 3 667 students in the classes were surveyed by using the Pittsburgh Sleep Quality Index Scale (PSQI) short form and the Chinese Middle School Students Mental Health Inventory (MMHI-60). Results: The prevalence of sleep deprivation among adolescents in Shandong Province was 37.44%, and the detection rate of psychological problems was 46.41%. Adolescent psychology could be divided into four latent categories:psychological immune group (39.6%), psychological low risk group (12.2%), psychological medium risk group (13.2%) and psychological high risk group (35.0%). Multifactorial Logistic regression analyses showed that gender, school year, sleep duration and sleep quality were influencing factors for the psychological latent categories ( OR =1.39-9.55, P < 0.05 ), and that adolescents with sleep deprivation and poor sleep quality were more inclined to be classified as being in the psychological medium and high risk groups. Conclusions The sleep and mental health of adolescents in Shandong Province is not very good. Comprehensive prevention and control of psychological problems should not only focus on personality and psychological characteristics, but also need to be combined with the sleep condition of adolescents.

BACKGROUND: Data on the immunogenicity and safety of heterologous immunization schedules are inconsistent. This study aimed to evaluate the immunogenicity and safety of homologous and heterologous immunization schedules. METHODS: Multiple databases with relevant studies were searched with an end date of October 31, 2021, and a website including a series of Coronavirus disease 2019 studies was examined for studies before March 31, 2022. Randomized controlled trials (RCTs) that compared different heterologous and homologous regimens among adults that reported immunogenicity and safety outcomes were reviewed. Primary outcomes included neutralizing antibodies against the original strain and serious adverse events (SAEs). A network meta-analysis (NMA) was conducted using a random-effects model. RESULTS: In all, 11 RCTs were included in the systematic review, and nine were ultimately included in the NMA. Among participants who received two doses of CoronaVac, another dose of mRNA or a non-replicating viral vector vaccine resulted in a significantly higher level of neutralizing antibody than a third CoronaVac 600 sino unit (SU); a dose of BNT162b2 induced the highest geometric mean ratio (GMR) of 15.24, 95% confidence interval [CI]: 9.53-24.39. Following one dose of BNT162b2 vaccination, a dose of mRNA-1273 generated a significantly higher level of neutralizing antibody than BNT162b2 alone (GMR = 1.32; 95% CI: 1.06-1.64), NVX-CoV2373 (GMR = 1.60; 95% CI: 1.16-2.21), or ChAdOx1 (GMR = 1.80; 95% CI: 1.25-2.59). Following one dose of ChAdOx1, a dose of mRNA-1273 was also more effective for improving antibody levels than ChAdOx1 (GMR = 11.09; 95% CI: 8.36-14.71) or NVX-CoV2373 (GMR = 2.87; 95% CI: 1.08-3.91). No significant difference in the risk for SAEs was found in any comparisons. CONCLUSIONS: Relative to vaccination with two doses of CoronaVac, a dose of BNT162b2 as a booster substantially enhances immunogenicity reactions and has a relatively acceptable risk for SAEs relative to other vaccines. For primary vaccination, schedules including mRNA vaccines induce a greater immune response. However, the comparatively higher risk for local and systemic adverse events introduced by mRNA vaccines should be noted. REGISTRATION PROSPERO; https://www.crd.york.ac.uk/PROSPERO/ ; No. CRD42021278149.
Adult ; Humans ; BNT162 Vaccine ; 2019-nCoV Vaccine mRNA-1273 ; Network Meta-Analysis ; Immunization Schedule ; COVID-19/prevention & control* ; COVID-19 Vaccines/adverse effects* ; Viral Vaccines ; mRNA Vaccines ; Antibodies, Neutralizing ; Antibodies, Viral