Objective To explore the effect of PCSK9 inhibitor combined with atorvastatin on carotid atherosclerosis and its anti-inflammatory effect in patients with hypertension complicated with type 2 diabetes mellitus.Methods A total of 100 patients with hypertension complicated with type 2 diabetes mellitus who were treated in Nanchang Third Hospital from October 2022 to August 2023 were selected as the research subjects.They were divided into the control group and the study group by the random number table method,with 50 cases in each group.Both groups of patients received conventional antihypertensive,hypoglycemic,and antiplatelet therapy.The control group took 20 mg of atorvastatin calcium tablets orally,once a night.On the basis of the control group,the study group was additionally given 150 mg of evolocumab injection(a PCSK9 inhibitor)by subcutaneous injection,once every two weeks.Both groups of patients were followed up for 24 weeks.The levels of blood lipids,blood glucose,inflammatory cytokines,carotid intima-media thickness(IMT),atherosclerotic plaque score and adverse reactions of the patients in the two groups before and after treatment were detected and compared.Results The levels of TC,TG and LDL-C in the study group after treatment were lower than those before treatment and those in the control group at the same period,and the differences were statistically significant(P＜0.05).The levels of IL-1,IL-6,TNF-α,hs-CRP,as well as the ca-rotid IMT and atherosclerotic plaque score in the study group after treatment were lower than those before treatment and those in the control group at the same period,and the differences were statistically significant(P＜O.05).During the treatment period,there was no significant difference in the occurrence of adverse reac-tions between the two groups(P＞0.05).Conclusion The combination of PCSK9 inhibitor and atorvastatin can effectively regulate the blood lipid levels of patients with hypertension complicated and type 2 diabetes mellitus,alleviate the inflammatory response,and improve the degree of carotid atherosclerosis in these pa-tients.

Objective:To sinicize the Obsessive and Compulsive Behaviors Scale of Mothers in Postpartum Period Regarding Baby Care (OCBS-MPPRBC) to test its reliability and validity, and to provide an evaluation tool for evaluating the degree of compulsive behaviors of postpartum mothers regarding baby care.Methods:Following the principles of Brislin translation, back translation and cross-cultural adaptation, the Chinese version of OCBS-MPPRBC was formed. A convenient sampling method was used to investigate 360 women in Mianyang Central Hospital from November 2023 to February 2024, and to test the reliability and validity of the Chinese version OCBS-MPPRBC. The critical ratio method and the total correlation analysis method were used for item analysis, the reliability test was based on Cronbach α coefficient and half-reliability method, and the content validity index, exploratory factor analysis, confirmatory factor analysis and aggregate validity were used for validity test. Results:A total of 352 women aged 21-41 (31.55 ± 3.17) years who met the exclusion criteria were included. The Chinese version of OCBS-MPPRBC contained 9 items, and 2 common factors were extracted by exploratory factor analysis, and the cumulative total variance contribution rate was 65.523%. The content validity index of the scale level was 0.89, the content validity index of each item level was 0.86-1.00, and the Cronbach α coefficient of the total scale was 0.844, and the half-folded reliability was 0.759. The results of confirmatory factor analysis showed that the fitting index of the Chinese version of the OCBS-MPPRBC model was better. Conclusions:The Chinese version of the OCBS-MPPRBC scale has good reliability and validity, and has good operability, which can be used to evaluate the degree of compulsive behavior of postpartum mothers about baby care in China.

Objective:To translate the Birth Satisfaction Scale-Revised (BSS-R) into Chinese and assesses the psychometric properties of this tool.Methods:Following the Beaton cross-cultural adaptation guidelines, the Chinese version of BSS-R was formed through forward translation, back translation, expert consultation, and pre-testing. The present study was conducted in a sample of 347 women took part between 6-8 weeks postpartum, from the postpartum clinics of two tertiary hospitals in Sichuan province.Results:Totally 340 questionnaires were effectively collected with a majority of respondents aged 30-39 accounting for 64.7% of the total. The Chinese version of BSS-R comprises 10 items, which were classified into three domains as stress experienced during labour, women′s personal attributes, and quality of care provision. The Cronbach α coefficient was 0.745 for the total scale and ranged from 0.523 to 0.738 for sub-scales. The split-half reliability was 0.746 for the total scale, and ranged from 0.523 to 0.733 for sub-scales. Exploratory factor analysis revealed the presence of three components with eigen values greater than 1, explaining a total variance of 58.868%. The fit indices showed that the original correlated three factor model of Chinese version of BSS-R was adequate.Conclusions:The Chinese version of BSS-R can be considered a clear, easily understandable and convenient tool for assessing the women′s birth satisfaction in Chinese cultural context.

Objective:To sinicize the Obsessive and Compulsive Behaviors Scale of Mothers in Postpartum Period Regarding Baby Care (OCBS-MPPRBC) to test its reliability and validity, and to provide an evaluation tool for evaluating the degree of compulsive behaviors of postpartum mothers regarding baby care.Methods:Following the principles of Brislin translation, back translation and cross-cultural adaptation, the Chinese version of OCBS-MPPRBC was formed. A convenient sampling method was used to investigate 360 women in Mianyang Central Hospital from November 2023 to February 2024, and to test the reliability and validity of the Chinese version OCBS-MPPRBC. The critical ratio method and the total correlation analysis method were used for item analysis, the reliability test was based on Cronbach α coefficient and half-reliability method, and the content validity index, exploratory factor analysis, confirmatory factor analysis and aggregate validity were used for validity test. Results:A total of 352 women aged 21-41 (31.55 ± 3.17) years who met the exclusion criteria were included. The Chinese version of OCBS-MPPRBC contained 9 items, and 2 common factors were extracted by exploratory factor analysis, and the cumulative total variance contribution rate was 65.523%. The content validity index of the scale level was 0.89, the content validity index of each item level was 0.86-1.00, and the Cronbach α coefficient of the total scale was 0.844, and the half-folded reliability was 0.759. The results of confirmatory factor analysis showed that the fitting index of the Chinese version of the OCBS-MPPRBC model was better. Conclusions:The Chinese version of the OCBS-MPPRBC scale has good reliability and validity, and has good operability, which can be used to evaluate the degree of compulsive behavior of postpartum mothers about baby care in China.

Objective:To translate the Birth Satisfaction Scale-Revised (BSS-R) into Chinese and assesses the psychometric properties of this tool.Methods:Following the Beaton cross-cultural adaptation guidelines, the Chinese version of BSS-R was formed through forward translation, back translation, expert consultation, and pre-testing. The present study was conducted in a sample of 347 women took part between 6-8 weeks postpartum, from the postpartum clinics of two tertiary hospitals in Sichuan province.Results:Totally 340 questionnaires were effectively collected with a majority of respondents aged 30-39 accounting for 64.7% of the total. The Chinese version of BSS-R comprises 10 items, which were classified into three domains as stress experienced during labour, women′s personal attributes, and quality of care provision. The Cronbach α coefficient was 0.745 for the total scale and ranged from 0.523 to 0.738 for sub-scales. The split-half reliability was 0.746 for the total scale, and ranged from 0.523 to 0.733 for sub-scales. Exploratory factor analysis revealed the presence of three components with eigen values greater than 1, explaining a total variance of 58.868%. The fit indices showed that the original correlated three factor model of Chinese version of BSS-R was adequate.Conclusions:The Chinese version of BSS-R can be considered a clear, easily understandable and convenient tool for assessing the women′s birth satisfaction in Chinese cultural context.

Objective To observe the morphological changes of levator hiatus in patients with gestational diabetes mellitus(GDM)after spontaneous delivery with ultrasonography.Methods A total of 302 pregnant women in the first trimester(6-8 weeks)were prospectively observed,and the parameters of pelvic floor muscle hiatus were measured with ultrasound during the first trimester,also 12 weeks,6 months and 1 year after delivery at resting-state(resting period),anal contraction state(systole period)and Valsalva maneuver(tension period),respectively.Blood glucose was measured at 28 weeks of gestation,GDM was diagnosed,and the pregnant women enrolled were divided into GDM group and non-GDM group.The ultrasonic parameters and postpartum pelvic floor muscle tension were compared between groups.Spearman correlation analysis was used to evaluate the correlations of pelvic floor muscle tension grade and anal levator hiatus parameters in GDM group.Results Totally 153 pregnant women were enrolled and assigned into GDM group(n=51)and non-GDM group(n=102).Transversal diameter of levator hiatus(LH-TD),anteroposterior diameter of levator hiatus(LH-APD)and levator hiatus area(LHA)in different periods 12 weeks postpartum in both groups were higher than those in early pregnancy(all P＜0.05).Six months and 1 year postpartum,in GDM group,LH-APD and LHA in systole period,also LH-TD,LH-APD and LHA in tension period were higher than those in early pregnancy(all P＜0.05),while in non-GDM group,LH-APD and LHA in tension period were higher than those of early pregnancy(all P＜0.05).One year after delivery,LH-APD and LHA in systolic period,as well as LH-TD and LHA in tension period in GDM group were all higher than those in non-GDM group(all P＜0.05),whereas the proportion of pelvic floor muscle tension of grade Ⅱ-Ⅲ was higher,of grade Ⅳ-Ⅴ was lower in GDM group than those in non-GDM group(P＜0.05).One year after delivery,pelvic floor muscle tone grade in GDM group was negatively correlated with LH-TD,LH-APD and LHA in resting,systole and tension period(all P＜0.05).Conclusion The morphology of levator hiatus changed greatly in GDM patients after spontaneous delivery,and rehabilitation training should be carried out early.

Objective:To analyze the factors influencing the occurrence of allergic diseases in infants and children aged 0-3 years.Methods:A case-control study was conducted to retrospectively analyze the clinical data of 90 infants and young children diagnosed with allergic diseases (observation group) admitted to Jinhua Maternal & Child Health Care Hospital from January 2019 to June 2023 and 80 healthy infants and young children undergoing routine health check-ups during the same period (control group). The clinical characteristics of the two groups were compared, and multivariate logistic regression analysis was performed to identify the factors influencing the occurrence of allergic diseases in infants and young children aged 0 to 3 years.Results:In the observation group, the proportions of infants with a family history of allergic diseases, exposure to smoking environments, maternal smoking exposure during pregnancy, maternal consumption of docosahexaenoic acid during pregnancy, and antibiotic use in infants were 77.8% (70/90), 55.6% (50/90), 66.7% (60/90), 61.1% (55/90), and 55.6% (50/90), respectively. All of these were significantly higher than those in the control group [31.3% (25/80), 25.0% (20/80), 25.0% (20/80), 25.0% (20/80), 25.0% (20/80), χ2 = 37.19, 16.33, 29.51, 22.40, 16.33, all P < 0.05]. The proportion of breastfeeding in the observation group was 44.4% (40/90), which was significantly lower than that in the control group [75.0% (60/80), χ2 = 16.33, P < 0.05]. Multivariate logistic regression analysis results revealed that family history of allergic diseases, non-breastfeeding, exposure to smoking environments, maternal smoking exposure during pregnancy, maternal consumption of docosahexaenoic acid during pregnancy, and antibiotic use in infants were risk factors for the occurrence of allergic diseases in infants and young children aged 0 to 3 years ( OR = 3.511, 3.688, 3.377, 3.728, 3.912, 4.023, all P < 0.05). Conclusion:A family history of allergic diseases, non-breastfeeding, exposure to smoking environments, maternal smoking exposure during pregnancy, maternal consumption of docosahexaenoic acid during pregnancy, and antibiotic use in infants are risk factors for the occurrence of allergic diseases in infants and young children aged 0 to 3 years. Clinically, these factors can be used to assess the likelihood of allergic diseases in infants.

Objective:To summarize the best evidence for the prevention and management of radiation esophagitis in patients with chest tumors, so as to provide basis for the prevention and management of radiation esophagitis in patients.Methods:The research question was proposed based on the population, intervention, professional, outcome, setting and type of evidence (PIPOST) model, and guidelines, expert consensus, clinical decision-making, evidence summary, systematic review, and randomized controlled trials on the prevention and management of radiation esophagitis in chest tumor patients were systematically searched on UpToDate, BMJ Best Practice, Cochrane Library, PubMed, American Society of Clinical Oncology, China National Knowledge Infrastructure, WanFang Data, and other databases and websites based on the "6S" model. The search period was from database establishment to August 1, 2023. Two researchers independently evaluated the quality of the literature and extracted and integrated evidence from the literature that met the quality standards.Results:A total of ten articles were included, including three guidelines, one expert consensus, one systematic review, two systematic evaluations, and three randomized controlled trials. Twenty-three pieces of evidence were summarized from six dimensions of building multidisciplinary teams, screening and evaluation, nutritional support, drug and non-drug prevention, integrated traditional Chinese and western medicine treatment, and health education.Conclusions:The included evidence can provide a theoretical basis for the prevention and management of radiation esophagitis in patients undergoing chest tumor radiotherapy. Clinical medical and nursing personnel can provide personalized interventions to patients based on clinical practice.

Objective:To translate the English version of the Questionnaire Assessing the Childbirth Experience (QACE) into Chinese and test its reliability and validity, enriching the evaluation tools used for delivery experience in China, providing guidance for medical personnel to evaluate the delivery experience of mothers, and providing reference for improving the delivery experience of mothers in the future.Methods:Based on Beaton ′s cross-cultural debugging guide, the Chinese version of QACE was developed, including correct translation, comprehensive, back translation, expert consultation and pre-test. The reliability and validity of the questionnaire survey was carried out on 235 participants who visited the postpartum clinic in West China Second Hospital, Sichuan University and Mianyang Central Hospital. Results:In 235 participants, aged 20-29 years old with 79 cases, aged 30-39 years old with 152 years old, aged 40-43 years old with 4 cases. The Chinese version of QACE consisted of 4 dimensions (emotional state, relationship with medical staff, first time spent with newborns, and feelings after 1 month postpartum) and 13 items. The Cronbach α coefficient of the scale was 0.812, the Cronbach α coefficient of each dimension was 0.661-0.844, and the broken half reliability was 0.527. The scale level content validity index was 0.95. Four common factors were extracted by exploratory factor analysis, and the cumulative variance contribution rate was 67.682%. Conclusions:The Chinese version of QACE has significant reliability and validity, and can be used to evaluate maternal delivery experiences.

Objective To study the effect of the proportion of atypical lymphocytes on the immune system of children with infectious mononucleosis(IM).Methods 153 children with IM admitted Jinhua Maternal and Child Health Care Hospital from May 2023 to May 2024 were selected as IM group,and 153 healthy children were selected as healthy group.The relationship between the proportion of atypical lymphocytes and EB virus load in IM patients was analyzed.The expression levels of immune system indicators[complement C3,C4,CD19+cells,T lymphocyte subsets,immunoglobulin(Ig)A,IgG,IgM]between two groups were detected and compared,the relationship between the proportion of atypical lymphocytes and immune system indicators was analyzed.The children with IM were divided into severe immune system disorder group and non-severe immune system disorder group according to the immune status,the clinical characteristics of children with severe immune disorder analyzed and compared the differences in the proportion of atypical lymphocytes.Results Compared with healthy group,the proportion of atypical lymphocytes in IM group increased(P<0.001).Pearson correlation test showed a positive correlation between the proportion of atypical lymphocytes and EB virus load in children with IM(P<0.05).Compared with healthy group,levels of complement C3,C4,CD8+T cells,IgA,IgG and IgM were increased in IM group,while CD4+T cells,CD4+/CD8+ratio,and CD19+cells were decreased(P<0.001).In children with IM,the proportion of atypical lymphocytes was negatively correlated with CD4+T cells,CD4+/CD8+ratio,and CD19+cells,and positively correlated with CD8+T cells,IgA,IgG and IgM(P<0.05).The increased proportion of atypical lymphocytes was a risk factor for the degree of immune system disorder in children with IM(P<0.001).Area under the curve for diagnosing immune system disorders in children with IM using the proportion of atypical lymphocytes was 0.918.Conclusion Children with IM exhibit varying degrees of immune system disorders,with specific immune disorders being the main cause.The degree of disorder is related to an increase in the proportion of atypical lymphocytes,which can serve as a reference indicator for early diagnosis of immune disorders in children with IM.