Acute lung injury (ALI) has been a kind of acute and severe disease that is mainly characterized by systemic uncontrolled inflammatory response to the production of huge amounts of reactive oxygen species (ROS) in the lung tissue. Given the critical role of ROS in ALI, a Fe₃O₄ loaded bovine serum albumin (BSA) nanocluster (BF) was developed to act as a nanomedicine for the treatment of ALI. Combining with NIR irradiation, it exhibited excellent ROS scavenging capacity. Significantly, it also displayed the excellent antioxidant and anti-inflammatory functions for lipopolysaccharides (LPS) induced macrophages (RAW264.7), and Sprague Dawley rats via lowering intracellular ROS levels, reducing inflammatory factors expression levels, inducing macrophage M2 polarization, inhibiting NF-κB signaling pathway, increasing CD4⁺/CD8⁺ T cell ratios, as well as upregulating HSP70 and CD31 expression levels to reprogram redox homeostasis, reduce systemic inflammation, activate immunoregulation, and accelerate lung tissue repair, finally achieving the synergistic enhancement of ALI immunotherapy. It finally provides an effective therapeutic strategy of BF + NIR for the management of inflammation related diseases.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

Objective:To comparative analyze the role and effectiveness of different healthcare consortium support models in enhancing the capacity of community health centers.Methods:Using community health service centers under the loose medical association support mode and the close medical association support mode as research subjects,the data on medical service capacity were quantitatively analyzed using DID(Difference-in-Difference).Results:Both close medical association and the loose medical association support models have increased the number of outpatient and emergency room visits,Chinese medicine consultations,and referrals to community health centers.The close medical association support model also increased the number of discharges from the community health centers.Conclusion:Close medical consortium can enhance the capacity of community health centers,and the effect is better than loose medical consortium.

For wild natural medicine, unanticipated biodiversity as species or varieties with similar morphological characteristics and sympatric distribution may co-exist in a single batch of medical materials, which affects the efficacy and safety of clinical medication. DNA barcoding as an effective species identification tool is limited by its low sample throughput nature. In this study, combining DNA mini-barcode, DNA metabarcoding and species delimitation method, a novel biological sources consistency evaluation strategy was proposed, and high level of interspecific and intraspecific variations were observed and validated among 5376 Amynthas samples from 19 sampling points regarded as "Guang Dilong" and 25 batches of proprietary Chinese medicines. Besides Amynthas aspergillum as the authentic source, 8 other Molecular Operational Taxonomic Units (MOTUs) were elucidated. Significantly, even the subgroups within A. aspergillum revealed here differ significantly on chemical compositions and biological activity. Fortunately, this biodiversity could be controlled when the collection was limited to designated areas, as proved by 2796 "decoction pieces" samples. This batch biological identification method should be introduced as a novel concept regarding natural medicine quality control, and to offer guidelines for in-situ conservation and breeding bases construction of wild natural medicine.