Objective To analyze the relationship between the expression levels of serum microRNA-214-3p and miR-124-3p with the severity of Parkinson's disease(PD),and their early diagnostic value.Methods From January 2018 to December 2023,96 PD patients admitted to Rugao Traditional Chinese Medicine Hospital were selected as the PD group,and 106 healthy individuals were selected as the control group.According to the severity of 96 patients,they were grouped into the early stage group(I-II stage,n=59)and the mid to late stage group(III-V stage,n=37).RT-qPCR was applied to detect serum levels of miR-214-3p and miR-124-3p.Spearman method was used for correlation analysis.The influencing factors of PD severity were analyzed using multiple Logistic regression analysis.The efficacy of serum miR-214-3p and miR-124-3p in diagnosing PD and its severity was analyzed by receiver operating characteristics(ROC).Results Compared with the control group,the serum levels of miR-214-3p and miR-124-3p were lower in the PD group(P＜0.05).Compared with the early stage group,there were a longer disease course,higher level of homocysteine(Hcy)and lower levels of serum miR-214-3p and miR-124-3p in the mid to late stage group(P＜0.05).Spearman analysis showed that serum miR-214-3p and miR-124-3p were negatively correlated with Hoehn-Yahr staging in PD patients(P＜0.05).Multivariate Logistic regression showed that disease duration(OR=1.249),Hcy(OR=1.156),serum miR-214-3p(OR=0.925)and miR-124-3p(OR=0.917)were factors influencing the severity of PD(P＜0.05).ROC analysis showed that the sensitivity and specificity of serum miR-214-3p and miR-124-3p combined in the diagnosis of PD were 85.42%and 81.90%respectively.The sensitivity and specificity of serum miR-214-3p and miR-124-3p in the diagnosis of advanced PD were 89.16%and 79.66%respectively.Conclusion The serum levels of miR-214-3p and miR-124-3p are relatively low in PD patients,and their levels are related to the severity of disease.The detection of serum miR-214-3p and miR-124-3p is helpful for the diagnosis and evaluation of PD.

Objective To analyze the relationship between the expression levels of serum microRNA-214-3p and miR-124-3p with the severity of Parkinson's disease(PD),and their early diagnostic value.Methods From January 2018 to December 2023,96 PD patients admitted to Rugao Traditional Chinese Medicine Hospital were selected as the PD group,and 106 healthy individuals were selected as the control group.According to the severity of 96 patients,they were grouped into the early stage group(I-II stage,n=59)and the mid to late stage group(III-V stage,n=37).RT-qPCR was applied to detect serum levels of miR-214-3p and miR-124-3p.Spearman method was used for correlation analysis.The influencing factors of PD severity were analyzed using multiple Logistic regression analysis.The efficacy of serum miR-214-3p and miR-124-3p in diagnosing PD and its severity was analyzed by receiver operating characteristics(ROC).Results Compared with the control group,the serum levels of miR-214-3p and miR-124-3p were lower in the PD group(P＜0.05).Compared with the early stage group,there were a longer disease course,higher level of homocysteine(Hcy)and lower levels of serum miR-214-3p and miR-124-3p in the mid to late stage group(P＜0.05).Spearman analysis showed that serum miR-214-3p and miR-124-3p were negatively correlated with Hoehn-Yahr staging in PD patients(P＜0.05).Multivariate Logistic regression showed that disease duration(OR=1.249),Hcy(OR=1.156),serum miR-214-3p(OR=0.925)and miR-124-3p(OR=0.917)were factors influencing the severity of PD(P＜0.05).ROC analysis showed that the sensitivity and specificity of serum miR-214-3p and miR-124-3p combined in the diagnosis of PD were 85.42%and 81.90%respectively.The sensitivity and specificity of serum miR-214-3p and miR-124-3p in the diagnosis of advanced PD were 89.16%and 79.66%respectively.Conclusion The serum levels of miR-214-3p and miR-124-3p are relatively low in PD patients,and their levels are related to the severity of disease.The detection of serum miR-214-3p and miR-124-3p is helpful for the diagnosis and evaluation of PD.

Objective:To estimate the lung cancer disease burden of residents caused by indoor radon exposure in living rooms in China, and to provide scientific basis for improving radon prevention and control policies and measures.Methods:Based on the data from the national indoor radon monitoring survey, the study of lung cancer caused by indoor radon, and the basic data such as population and smoking, the attributable burden of disease calculation method was used to estimate the disease burden of lung cancer caused by indoor radon in China.Results:In 2018, it was estimated that the years of life lost due to premature death (YLL), years of life lost due to health disability (YLD) and disability-adjusted life years (DALY) due to indoor radon exposure were 5.109 3 million, 0.052 6 million and 5.161 9 million, respectively. DALY was highest in the 50-54 age group. The disease burden of indoor radon-induced lung cancer in smoking men was more than 9 times that of smoking women, and the disease burden of lung cancer in non-smoking women was more than 5 times that of non-smoking men. Smoking is closely related to the disease burden of indoor radon-induced lung cancer.Conclusions:Indoor radon exposure is a major environmental risk factor associated with lung cancer burden in China. The health hazards of indoor radon require more attention and improved policy measures to address this challenge.

OBJECTIVE: We aimed to analyze the current indoor radon level and estimate the population risk of radon-induced lung cancer in urban areas of China. METHODS: Using the passive monitoring method, a new survey on indoor radon concentrations was conducted in 2,875 dwellings across 31 provincial capital cities in Chinese mainland from 2018 to 2023. The attributable risk of lung cancer induced by indoor radon exposure was estimated based on the risk assessment model. RESULTS: The arithmetic mean (AM) and geometric mean (GM) of indoor radon concentrations were 65 Bq/m³ and 55 Bq/m³, respectively, with 13.6% of measured dwellings exceeding 100 Bq/m³ and 0.6% exceeding 300 Bq/m³. The estimated number of lung cancer deaths induced by indoor radon exposure was 150,795, accounting for 20.30% (95% CI: 20.21%-20.49%) of the lung cancer death toll. CONCLUSION This study provided the most recent data on national indoor radon levels in urban areas and the attributable risk of lung cancer. These results served as an important foundation for further research on the disease burden of indoor radon exposure and radon mitigation efforts.
Radon/analysis* ; China/epidemiology* ; Air Pollution, Indoor/analysis* ; Lung Neoplasms/etiology* ; Humans ; Cities/epidemiology* ; Air Pollutants, Radioactive/adverse effects* ; Neoplasms, Radiation-Induced/etiology* ; Risk Assessment ; Radiation Monitoring

Objective:To estimate the lung cancer disease burden of residents caused by indoor radon exposure in living rooms in China, and to provide scientific basis for improving radon prevention and control policies and measures.Methods:Based on the data from the national indoor radon monitoring survey, the study of lung cancer caused by indoor radon, and the basic data such as population and smoking, the attributable burden of disease calculation method was used to estimate the disease burden of lung cancer caused by indoor radon in China.Results:In 2018, it was estimated that the years of life lost due to premature death (YLL), years of life lost due to health disability (YLD) and disability-adjusted life years (DALY) due to indoor radon exposure were 5.109 3 million, 0.052 6 million and 5.161 9 million, respectively. DALY was highest in the 50-54 age group. The disease burden of indoor radon-induced lung cancer in smoking men was more than 9 times that of smoking women, and the disease burden of lung cancer in non-smoking women was more than 5 times that of non-smoking men. Smoking is closely related to the disease burden of indoor radon-induced lung cancer.Conclusions:Indoor radon exposure is a major environmental risk factor associated with lung cancer burden in China. The health hazards of indoor radon require more attention and improved policy measures to address this challenge.

Objective:To estimate the attribution share of residents′lung cancer caused by indoor Radon.Methods:Based on the 2015 lung cancer mortality, all-cause mortality from China together with nationally representative smoking rate and the average indoor radon concentration of 30 Bq/m 3, the relatively authoritative and applicable EPA/BEIR-VI risk model was used to predict the lung cancer mortality caused by indoor radon exposure. Results:The excess relative risk (ERR) of indoor radon-related lung cancer mortality among the male non-smokers is higher than that of smokers. For the age-group above 50, the male smokers and male non-smokers have the highest ERR values, which were 0.511 and 0.230, respectively. Assuming the exposure incurred starting at age 0 with the same radon concentration, the lifetime risk of men and women non-smokers is higher than that of the smokers of the same gender. The higher the radon concentration, the higher the lifetime risk of lung cancer. Assuming that the radon concentration level in China is 30 Bq/m 3, the number of deaths from indoor radon-related lung cancer in 2015 is about 55 512. According to this, about 6.62% of lung cancers are caused by indoor radon exposure. If we assume that radon concentration levels are 40 Bq/m 3and 70 Bq/m 3 in China, approximately 8.82% and 15.38% of lung cancer deaths can be attributed to indoor radon exposure. Conclusions:Indoor radon exposure is an important environmental factor that causes Chinese residential lung cancer. Effective measures should be taken to prevent and control the increasing indoor radon levels. In order to accurately assess risk of lung cancer morality caused by indoor radon, more detailed data such as the indoor radon level in China are needed.

Objective Collect and analyze data of radiation level of ²¹⁰Po/²¹⁰Pb in cigarettes in China, evaluate the internal radiation dose caused by smoking to Chinese smokers and compare it with other countries. Methods The radiation levels of ²¹⁰Po/²¹⁰Pb in cigarettes in domestic and foreign countries were summarized and analyzed, and the fractions of ²¹⁰Po/²¹⁰Pb in mainstream smoke were recommended, and the internal radiation doses to smokers in China were estimated. Results In 2015, there were 320 million smokers among aged 15 and above in China with an average smoking amount of 15.2 cigarettes per day. The average activities of ²¹⁰Po/²¹⁰Pb weighted by the number of cigarette brands were 28.2 mBq per cigarette and 39.3 mBq per cigarette respectively. The mainstream smoke fraction of 20% of ²¹⁰Po was used to make the does estimation which was the mean value of the experimental results of simulator and volunteers, and that of ²¹⁰Pb was 10% measured by simulators. Based on the average smoking amount per day and the number of smokers in China, the annual effective dose of current smokers in China is 126 μSv·a⁻¹, and the collective effective dose is 40746 man·Sv. Conclusion The content of ²¹⁰Po/²¹⁰Pb in Chinese cigarettes is about 2～3 times that of other country's cigarettes. However, the fraction of mainstream smoke and dose conversion coefficient of ²¹⁰Po/²¹⁰Pb adopted in this paper are different from those in other literatures. Therefore, the estimated dose of 20 cigarettes for Chinese smokers is lower than that for smokers in some countries.

The rapid development of medical application of ionizing radiation has seen a range of safety and protection problems that might be of importance. This paper aims to introduce the current situation and existing problems in the public medical exposure, and to propose the relevant suggestions, based on a combination of judgment of medical radiation exposure justification, quality assurance and control of equipment in radiodiagnosis and radiotherapy, occupational protection of radiation workers, and health effects on patients undergoing radiodiagnosis and radiotherapy.